Treatment for Amoeba infections - nanosilver plus antispasmotics

[Bob]

It's not colloidal silver, doing the work for killing off dangerous amoeba infections in areas of the brain and eyes, where untreated leads to a horrible death and blindness...

It is silver though, in the form of nano-particle coatings attached to common anti-spasmotic anti-seizure drugs used to treat conditions such as seizures.

We have a thread referenced here: https://projectavalon.net/forum4/show...l=1#post982932 which talks about a particular type of amoeba that can contaminate water systems.

The two types of amoebas are known as:

• Naegleria fowleri - a brain eating amoeba
• Acanthamoeba castellanii - can enter the eyes through dirty contact lenses

Here are excerpts from the article of October 24, 2018, from the American Chemical Society:

Most cases result from inhaling warm, dirty water in ponds, hot springs or un-chlorinated swimming pools.

Another species, Acanthamoeba castellanii, can cause blindness by entering the eyes through dirty contact lenses.

Common treatments include antimicrobial drugs, but they often cause severe side effects because of the high doses required for them to enter the brain.

Researchers Ayaz Anwar and colleagues wondered if three anti-seizure drugs—diazepam, phenobarbitone and phenytoin—could kill amoebae, alone or in combination with silver nanoparticles.

The drugs are already approved by the U.S. Food and Drug Administration and are known to cross the blood-brain barrier.

The researchers reasoned that they might be more effective when attached to silver nanoparticles (not colloidal silver), which can improve the delivery of some drugs and also have their own antimicrobial effects.

Technical:
How the nanoparticles were created - Nanoparticles were synthesized by sodium borohydride reduction of silver nitrate with drugs as capping agents. Drugs conjugated nanoconjugates were characterized by ultraviolet-visible (UV-vis), and Fourier transform infrared (FT-IR) spectroscopies, and atomic force microscopy (AFM).

article references:
https://phys.org/journals/acs-chemical-neuroscience/
https://phys.org/news/2018-10-brain-...particles.html

Ayaz Anwar - Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor, Malaysia. - https://aac.asm.org/content/early/20...6/AAC.00630-18 - in this article Anwar and colleagues used gold nanoparticles attached to Cinnamic acid to kill the Acanthamoeba castellanii type of amoeba. The gold-nanoparticle-cinnamic acid combination was also effective in killing MRSA bacteria - methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1.

[Bob]

A brief aside - what is cinnamic acid - It is obtained from oil of cinnamon, or from balsams such as storax. It is also found in shea butter.

Anwar and colleagues used gold nanoparticles attached to Cinnamic acid to kill the Acanthamoeba castellanii type of amoeba. The gold-nanoparticle-cinnamic acid combination was also effective in killing MRSA bacteria - methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1.

It might be interesting to see how cinnamon has been used in treatments for amoeba (and other) infections..

[Flash]

Posted by Bob (here)
A brief aside - what is cinnamic acid - It is obtained from oil of cinnamon, or from balsams such as storax. It is also found in shea butter.

Anwar and colleagues used gold nanoparticles attached to Cinnamic acid to kill the Acanthamoeba castellanii type of amoeba. The gold-nanoparticle-cinnamic acid combination was also effective in killing MRSA bacteria - methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1.

It might be interesting to see how cinnamon has been used in treatments for amoeba (and other) infections..

hum, much more interesting than what is going on with Geoff, at least there is some utility to the research you are writing about here.

Doctors should know these things.

Cinammon is also useful in diabetis, helping reduce the glucose count. i wonder if it may be related to Cinnamic acid.

I had amoebic disentry when younger, in Mexico and was very near death when I got treated. Therefore my interest and the knowledge on how damaging amoebas can be.