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Thread: Covid19: Global reports, news and updates

  1. Link to Post #101
    Madagascar Avalon Member silvanelf's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by carnavas (here)
    ... but there’s a big rumor about a new japanese and now manufactured by chinese drug called avigan (favipiravir) here and that it has been priscribed for a high rank government official(Ali Larijani) and it is sold in the black market for like 3 thousand dollars a sheet, I don’t know wether they created these rumors to sell the drug or that it is more effective than chloroquine
    Thank you for mentioning avigan (favipiravir) -- I found some more info:

    Quote Japan to boost Avigan drug stockpile as part of coronavirus stimulus

    TOKYO (Reuters) - Japan is considering increasing the stockpile of Fujifilm Holding Corp’s Avigan anti-flu drug during this fiscal year so it can be used to treat 2 million people, according to a planning document seen by Reuters.

    Local media reported on Sunday that Japan was hoping to triple the production of the drug from current levels, which is enough to treat 700,000 people if used by coronavirus patients.

    Avigan, also known as Favipiravir, is manufactured by a subsidiary of Fujifilm, which has a healthcare arm although it is better known for its cameras. The drug was approved for use in Japan in 2014. Avigan is being tested in China as a treatment for COVID-19.

    --- snip ---
    https://www.reuters.com/article/us-h...-idUSKBN21N026


    Quote Japanese flu drug 'clearly effective' in treating coronavirus, says China
    Shares in Fujifilm Toyama Chemical, which developed favipiravir, surged after praise by Chinese official following clinical trials

    Medical authorities in China have said a drug used in Japan to treat new strains of influenza appeared to be effective in coronavirus patients, Japanese media said on Wednesday.

    Zhang Xinmin, an official at China’s science and technology ministry, said favipiravir, developed by a subsidiary of Fujifilm, had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients.

    “It has a high degree of safety and is clearly effective in treatment,” Zhang told reporters on Tuesday.

    Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug, public broadcaster NHK said.

    In addition, X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug.

    --- snip ----
    https://www.theguardian.com/world/20...rus-says-china

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  3. Link to Post #102
    Norway Avalon Member
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    Default Re: Covid19: Global reports, news and updates

    Reinfection vs reactivation:

    Quote Cured virus patients might have tested positive due to virus reactivation: KCDC

    April 06, 2020
    en.yna.co.kr


    SEOUL, April 6 (Yonhap) -- More than 50 people who recovered after contracting COVID-19 have tested positive again, but the results might have been due to the reactivation of the novel coronavirus, health authorities here said Monday.

    The Korea Centers for Disease Control and Prevention (KCDC) said 51 people from Daegu and the surrounding North Gyeongsang Province, the epicenters of the COVID-19 outbreak here, had tested positive for the virus after they were released from quarantine.

    KCDC Director-General Jeong Eun-kyeong said the virus was highly likely to have been reactivated, instead of the people being reinfected, as they tested positive again in a relatively short time after being released from quarantine.

    The health authorities said a team of investigators has been sent to Daegu to conduct an epidemiological investigation into the cases.

    Other virologists and epidemiologists said the positive results from the retesting may have come from the virus reactivating and not from wrong diagnoses.

    "There is a pattern of the viral level decreasing and increasing again. An investigation should be thoroughly conducted into whether the level was low enough to show as negative," said Jegal Dong-wook, an infectious disease expert at the Catholic University of Korea.

    They also said the COVID-19 virus may remain latent in certain cells in the body and attack the respiratory organs again once reactivated.

    "Patients who retested positive are people in which the virus was reactivated or who relapsed," said Kim Tae-kyung, an infectious disease expert at Soonchunhyang University Hospital.

    A COVID-19 patient is deemed fully recovered after showing negative results for two tests performed with a 24-hour interval.

    The country recorded fewer than 50 new cases of the novel coronavirus Monday, bringing the nation's total infections to 10,284. It marked the lowest daily increase since late February.

    khj@yna.co.kr
    (END)
    -----------------

    Trump: WHO is China-Centric, 'Really Blew it' on Coronavirus

    Quote "The W.H.O. really blew it," Trump said in a Twitter post. "For some reason, funded largely by the United States, yet very China centric. We will be giving that a good look. Fortunately I rejected their advice on keeping our borders open to China early on. Why did they give us such a faulty recommendation?"
    Last edited by Sophocles; 7th April 2020 at 18:40.

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  5. Link to Post #103
    Scotland Avalon Member greybeard's Avatar
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    Default Re: Covid19: Global reports, news and updates

    1. Britain set for 66,000 COVID-19 deaths, highest toll in Europe: study


    https://uk.yahoo.com/news/britain-se...134706494.html

    (Chris says. How on earth do they get that figure, notice they are implying a second wave will happen)


    Britain could see as many as 66,000 COVID-19 deaths during the first wave of the current pandemic, new research showed Tuesday, making the outbreak there by far the deadliest in Europe.

    Modelling conducted by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington's School of Medicine showed that approximately 151,680 people were likely to die from the virus across the continent.

    While the novel coronavirus emerged in China and was initially focussed in east Asia, the World Health Organization now says the pandemic is centred in western Europe, with Spain, Italy and France experiencing devastating death tolls.

    Most European nations have introduced strict social distancing measures to try to stem the virus spread.

    More than 5,000 people have died from COVID-19 in Britain, fewer than in Spain, Italy and France.

    But Britain's epidemic lags behind the rest of the continent by several days, and its death toll trajectory is already steeper than other nations.

    Using local and international data on case numbers, as well as age mortality breakdowns from Italy, China and the US, the team at IHME modelled the expected death toll on a country-by-country basis.

    A key consideration was an individual nation's intensive care bed capacity.

    It found that Britain could experience 66,000 COVID-19 deaths by July, far more than Italy, the next most severely impacted, with around 20,000.

    Spain and France were next, with 19,000 and 15,000 predicted deaths, respectively.

    "We are expecting a foreboding few weeks for people in many parts of Europe," said IHME Director Christopher Murray.

    "It seems likely the number of deaths will exceed our projections for the United States.

    On Sunday the institute predicted just over 80,000 US COVID-19 deaths during the pandemic's first wave.

    The modelling suggests that outbreaks in Italy and Spain, where hundreds of deaths have been reported daily for weeks, may be past their peak.

    Daily deaths in both countries have declined for several days.

    But Britain is likely weeks away from getting a handle on its death toll as intensive care capacity is overwhelmed.

    Peak demand was forecast to see more than 100,000 hospital beds needed versus the 17,765 currently available.

    "The peak for Europe as a whole is expected in the third week of April," said Murray

    - Could still get worse -

    Prime Minister Boris Johnson, who is currently in intensive care with COVID-19, came in for criticism for his government's slow response to the pandemic.

    Britain now has strict social distancing measures in place, but it had held off implementing them even as the outbreak surged in Europe.

    The IHME models include the predicted effect of social distancing, and Murray said it was vital that measures are not relaxed too suddenly once countries pass their mortality peak.

    "It is unequivocally evident that social distancing can, when well implemented and maintained, control the epidemic, leading to declining death rates," Murray said.

    "Those nations hit hard early on implemented social distancing orders and may have the worst behind them as they are seeing important progress in reducing their death rates.

    "Each nation's trajectory will change -– and dramatically for the worse -– if people ease up on social distancing or relax other precautions."
    Last edited by greybeard; 7th April 2020 at 18:19.
    Be kind to all life, including your own, no matter what!!

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  7. Link to Post #104
    France Avalon Member araucaria's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Just overheard on French TV: 70% of Covid patients (in intensive care) are overweight if not obese. If this is a genuine factor, then the UK and the US curves may well prove steeper than France or Italy.


    According to Le Monde, this figure is as high as 83%, but this already includes some UK stats.
    Last edited by araucaria; 7th April 2020 at 19:14.


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  9. Link to Post #105
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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by DaveToo (here)
    Only in America...

    Washington — "A conservative lawyer has filed a class-action lawsuit against China for the coronavirus pandemic, pushing an unsubstantiated claim that the Chinese government developed the virus as an illegal biological weapon to unleash on the world.
    Lawyer Larry Klayman and his group Freedom Watch filed the complaint in federal court in Texas seeking at least $20 trillion from the Chinese government because of its "callous and reckless indifference and malicious acts."

    https://www.cbsnews.com/news/coronav...over-outbreak/
    How do you file a law suit without evidence, proof? Just baffled, I guess.

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  11. Link to Post #106
    Avalon Member T Smith's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by sunwings (here)
    In Northern Italy, 60 volunteers who thought they had never suffered COVID-19 gave blood. 40 tested positive.
    Not to beat a dead horse (we have hashed this out ad nauseum), but a very plausible explanation of this is the faulty testing protocols... a positive test may be detecting something, but not necessarily 1) SARS CoV-2 or 2) something that will ever make us sick.

    Quote Posted by sunwings (here)
    All asymptomatic, escaped from official statistics: they came into contact with the disease, they did not develop it, but they have....Along with the Imperial College data, it is clear there are millions of asymptomatic cases. Why isn´t MSM not using this angle? I can only see two ways out of this, herd immunity or vaccines. Neither seems very appealing.(you have to pay to see more)...
    Alternatively:

    If the vast majority of the people test positive (it's not a statistical sample, but nonetheless indicates 67% of people walking around have no idea they even have it) could indicate we already have herd immunity or are well on our way to herd immunity. For now, I'll reserve all judgement until I see some antibody studies come out, both on a random swath of the population and among those who have supposedly tested positive, per the current RT-PCR testing technology.

    The cynic in me isn't expecting those studies to surface anytime soon...
    Last edited by T Smith; 8th April 2020 at 01:01.

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  13. Link to Post #107
    UK Moderator/Librarian/Administrator Tintin's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by Elainie (here)
    The good news about hydroxychloroquine continues to pour in. Last week, Dr. William Grace, an oncologist affiliated with Lenox Hill Hospital in New York City, said they’ve not had any deaths in the hospital of close to a 100 patients. In an interview with Fox News host Laura Ingraham, Dr. Grace said: “Thanks to hydroxychloroquine, we have not had a death in our hospital.’https://techstartups.com/2020/03/30/...eath-hospital/
    Thanks Elainie

    Here's the transcript from the interview:

    “Everybody’s using it [chloroquine] now off-label. We have a surge of coronavirus-19 patients throughout the metropolitan area of New York. And the problem is these patients are coming in quite sick. And when they get to a very difficult respiratory status, doctors are using hydroxychloroquine [an “analog” of chloroquine] with or without a drug called Zithromax or azithromycin. And that’s showing tremendous activity, and we have not had a death in our hospital. We have probably close to 100 patients and not had any deaths. But I’ve talked to my colleagues at other hospitals in New York, and they are using hydroxychloroquine although the supplies are running down. So any kind of supplements to those supplies would be much appreciated…. In the trenches, we’re all using it especially for desperately ill people…. We’re not using it on everybody, but we’re using it on those people who show major respiratory compromise…

    We think it works in two ways. As you know, the death rate goes up as the age goes up. And what I think is that the more mature your immune response, the more likely you are to have what we call a cytokine storm, which means that people with viral pneumonia die because their lungs fill up with fluids largely from an immune response. And this drug works not only inhibiting virus replication but also inhibits the immune response.”
    “If a man does not keep pace with [fall into line with] his companions, perhaps it is because he hears a different drummer. Let him step to the music which he hears, however measured or far away.” - Thoreau

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    Default Re: Covid19: Global reports, news and updates

    SOME SWEDISH HOSPITALS HAVE STOPPED USING CHLOROQUINE TO TREAT COVID-19 AFTER REPORTS OF SEVERE SIDE EFFECTS

    Several hospitals in Sweden have reportedly stopped administering chloroquine to coronavirus patients following reports the drug was causing adverse side effects.

    According to the national paper Expressen, hospitals in the Västra Götaland region are no longer offering the antimalarial medication, with side effects reported to include cramps and the loss of peripheral vision.

    https://www.newsweek.com/swedish-hos...ffects-1496368

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  17. Link to Post #109
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    Default Re: Covid19: Global reports, news and updates

    Apparently said by this W.H.O. official last week. Apologies if already posted I didn't see it, but couldn't be more worth repeating.

    W.H.O. Official: "May have to enter homes and remove family members"
    672,124 views•Apr 7, 2020






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    Default Re: Covid19: Global reports, news and updates

    Virginia Guiffre/Virginia Roberts

    Oh, how the Epstein 'affair' seems so long ago now (but not forgotten here at Project Avalon). EDIT to add: also posted by Bill here on the Epstein thread http://projectavalon.net/forum4/show...=1#post1349163

    Unfortunately Virginia does now seem to have become one of the latest victims to fall foul of this virus, here photographed in an ICU in Australia. From her Twitter feed earlier today, April 7th. A simple get well message has been retweeted from our account.

    Last edited by Tintin; 8th April 2020 at 00:23.
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  21. Link to Post #111
    UK Avalon Member sunwings's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by Bill Ryan (here)
    Quote Posted by DaveToo (here)
    Quote Posted by Bill Ryan (here)

    There are similar problems in many other developing countries, so it's serious — and it'll get much worse before it gets better. I really fear for Africa and India, where there are disasters lying in wait to happen just a few weeks from now.
    Bill wouldn't you agree that what is taking place by the government of India is absolutely ludicrous?

    The country has a population of 1.3 billion.
    There have been 3588 Covid-19 cases so far and a whopping 99 deaths!

    Possibly a slight over-reaction on the part of the government?
    No, not an over-reaction. An early reaction.

    Look at the shape of the exponential graph in my post immediately above. The numbers are super-low in India right now — of course. But if it grabs hold and spreads fast, there's a huge disaster there waiting to happen. So the Indian government is trying to slow that down, if at all possible, simply to give them time to cope.

    I've traveled in India several times. Back in 1981, when I was first there, 10,000 homeless, desperately poor people slept every night in Calcutta main railway station (now renamed Kolkata), and trucks would come every morning to take away the dead bodies.

    It's better now, but there are still huge slums, widespread poverty, and extremely crowded cities. It's not nearly as wealthy and organized as China is. My personal opinion is that the government has an almost impossible challenge to contain the thing there. I'm very worried about it, and I'm certain the government is, too.
    The Indian Government have acted...



    The Indian people need them to.

    Click image for larger version

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  23. Link to Post #112
    United States Avalon Member mgray's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Mr. President assemble a US back-to-work task force. My thoughts
    When in doubt, do the next right thing.
    My blog: http://grayseconomy.com

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    Default Re: Covid19: Global reports, news and updates

    Quote Posted by shaberon (here)
    I see about 500 new cases here since yesterday, getting right at 3,000. Of these, 270 hospitalized.

    Like with unemployment, businesses have trouble getting their loans. If you were at Wells Fargo, they were capped at $10 billion due to making false accounts in 2018. But, due to the inconvenience, the punishment may be lifted. Anyway, a bunch of those customers were suddenly cut off on Saturday.

    And then you will find places only serving current customers, along with websites getting overloaded and quit working.

    Bank of America has 177,000 applications for $32 billion, so, that is actually about $180k per loan. Theoretically, a big chunk of this is supposed to cover payroll.

    I am told the line at Wal-mart wraps around the building, but so far I haven't seen anything unusual in the small town. This stuff has broken into several prisons around the country, but, out here in most of the rural areas, there's nothing.

    Unemployment, of course, is worse than having your payroll covered, being a portion of what was barely enough to scrape by. I don't know why "help" always assumes you were living in largess with a lot to dispose of. I tried to get more of this earlier, but, it wasn't working.
    I was told by my bank last Thursday (UnionBank) that the loan program hadn't even launched yet.

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    Default Re: Covid19: Global reports, news and updates

    I'm listening to the news tonight and I heard Tucker say that the hospitals are not separating Covid 19 from pneumonia .
    So i did some research and found the yearly deaths of pneumonia, and then of the influenza flu /

    https://www.rightdiagnosis.com/p/pneumonia/deaths.htm
    Death rate extrapolations for USA 2018 for Pneumonia: 61,776 per year,

    https://www.statnews.com/2018/09/26/...deaths-winter/
    And 80 thousand deaths from influenza THE FLU in 2018

    60 thousand Pnemonia, YEARLY RATE and 80 thousand per year for flu

    So 60 thousand Pneumonia and 80 thousand flu is 140 thou

    AND THIS IS WITHOUT COVID 19

    so what are we counting in this Covid 19 death rate? If we are including pneumonia within this than the actual COVID 19 numbers are much lower.

    is this some statistical bait and switch ? Im still scratching my head
    Last edited by thepainterdoug; 8th April 2020 at 01:27.

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    United States Avalon Member Joe's Avatar
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    Default Re: Covid19: Global reports, news and updates

    ............
    Last edited by Joe; 10th April 2020 at 14:27.

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    Default Re: Covid19: Global reports, news and updates

    From 2015 the theme of 2020, spreading like a virus.

    I am the Virus!

    Oel ngati kame

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    United States Avalon Member onawah's Avatar
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    Default Re: Covid19: Global reports, news and updates

    News and Updates from Dr. Mercola
    (Go to this link to find the articles):
    https://blogs.mercola.com/sites/vita..._rid=845889102

    Why You Want to AVOID CT Scans with COVID-19 and Use Ultrasound Instead
    April 7, 2020

    CT Scans emit enormous amounts of ionizing radiation, up to 100 times more than a chest-X ray. If you do have to get a CT scan it would be wise to have high ketone levels as they have been shown to reduce the ionizing radiation damage. We will be...

    Revised Model Now Predicts SARS-CoV-2 Deaths To Be Less than Half Predicted
    April 7, 2020

    Public health officials now say deaths due to SARS-CoV-2, will be around 81,766 when the final tally is done, much fewer than the 200,000 deaths that Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases,...

    New Study Points to Vitamin D as Possible Answer to Pandemic
    April 7, 2020

    A new study shows that simply supplementing with vitamin D — the “sunshine” vitamin — may be a possible answer to fighting and possibly preventing not only coronavirus, but other respiratory infections, as well. 1 From...

    New Study Shows Ivermectin Reduces Replication of SARS-Cov-2
    April 6, 2020

    A new study published in the journal Antiviral Research finds that Ivermectin, a common agricultural drug used as a de-wormer for cats, dogs, horses and livestock — achieves a 5000-fold reduction in replication of SARS-CoV-2. Source: Antiviral...

    Could a Common Malaria Drug Be the Cure for COVID-19?
    April 6, 2020

    A common drug used to fight malaria is being rolled out in New York, with 4,000 patients receiving hydroxychloroquine in rounds of four- or 10-day doses. Also notable is that the Bill & Melinda Gates Foundation is bankrolling a different trial...

    Bill Gates Banks on His Own Vaccine for Coronavirus
    April 6, 2020

    If billionaire Bill Gates’ dream for a coronavirus comes true, it will be ready for you by the end of this year. Funded by the Bill & Melinda Gates Foundation, biotech Inovio will begin injecting volunteers with the vaccine today, April 6,...

    Lost Sense of Smell, Taste a Warning Sign of Coronavirus
    April 6, 2020

    A New York City nurse who struggled to get tested for COVID-19 worked for about a week while infected. CNN reported the nurse, 44, who worked with patients who had coronavirus, finally tricked her way into getting tested, asking a colleague in ER to...

    Will Artificial Intelligence Help Us Out of This Mess?
    April 5, 2020

    David Silver leads the deep reinforcement learning group at Deep Mind and is the lead programmer of the team that created Alpha Go and Alpha Zero that defeated the World Go Champion. Lex Fridman teaches artificial intelligence at M.I.T and believes...

    Why Molecular Hydrogen Could Prevent Many COVID-19 Deaths
    April 4, 2020

    Molecular hydrogen (H2 gas) has antioxidant and anti-inflammatory effects, which make it potentially useful for COVID-19 as explained in this video by Tyler LeBaron.
    Each breath a gift...
    _____________

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    Netherlands Avalon Member gini's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Tucker Carlson Tonight 7 april with careful optimism about the decreasing numbers and the apparent passing of the peak of the epidemic,the hopeful and maybe not so alarming situations of the hospitals, the testing,the crashing economy,the counting of the death and the confusion about tcovid 19 as the main cause ,the effectiveness and politricks with hydroxocloroquine,and more pretty refreshing questions and opinions for a popular mainstream newsshow!
    https://www.youtube.com/watch?v=sOnyk9zuEio

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  37. Link to Post #119
    Madagascar Avalon Member silvanelf's Avatar
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    Default Re: Covid19: Global reports, news and updates

    Quote Data scientist reveals EYE PAIN may be a symptom of Covid-19 after tracking Google searches in some of the worst-hit American states
    • Searches for the phrase 'loss of smell' highest in NY, NJ, Louisiana and Michigan
    • Data scientist argues Google searches can determine next outbreak of Covid-19
    • He also says there is evidence to suggest eye pain could be a symptom of virus

    A data scientist has claimed that Google search results from around the world could be key to determining undiscovered coronavirus symptoms as well as locating emerging outbreaks.

    Seth Stephens-Davidowitz explained how Google searches for the phrase 'loss of smell' align with the number of positive cases of coronavirus, and why he believes eye pain could be another unofficial signal of the illness.

    Most researchers now agree that loss of smell and taste is a symptom of Covid-19, affecting up to 60% of those who contract the illness.

    Searches for the phrase 'loss of smell' in the US were highest in New York, New Jersey, Louisiana, and Michigan, which are four cities worst hit by the outbreak.

    Mr Stephens-Davidowitz went on to predict that Ecuador could become a new epicentre for the virus based on people's Google searches.

    Writing in the New York Times, Mr Stephens-Davidowitz said: 'Searches for "no puedo oler" ("I can't smell") are some 10 times higher per Google search in Ecuador than they are in Spain, even though Ecuador officially reports more than ten times fewer Covid-19 cases per capita than Spain does.

    'Ecuadoreans are also right near the top in searches for fever, chills and diarrhea.'

    Mr Stephens-Davidowitz argued that based on Google's search history, there is evidence to suggest eye pain could also be considered a symptom of the virus.

    'Notably, searches for eye pain rose above fourfold in Spain between the middle of February and the middle of March and rose about 50 percent in Iran in March.

    --- snip ---
    more at link: https://www.dailymail.co.uk/news/art...-Covid-19.html

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  39. Link to Post #120
    Avalon Member leavesoftrees's Avatar
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    Default Re: Covid19: Global reports, news and updates

    This article discusses why hydroxychloroquine works - because Covid 19 attacks haemoglobin in the same way as malaria does by inhibiting its ability to carry oxygen from the lungs to the rest of the body. In the process toxic iron ions are released into the lung tissues from the alveoli thereby causing the extensive lung damage

    http://web.archive.org/web/202004050...t-91182386efcb

    Covid-19 had us all fooled, but now we might have finally found its secret.

    In the last 3–5 days, a mountain of anecdotal evidence has come out of NYC, Italy, Spain, etc. about COVID-19 and characteristics of patients who get seriously ill. It’s not only piling up but now leading to a general field-level consensus backed up by a few previously little-known studies that we’ve had it all wrong the whole time. Well, a few had some things eerily correct (cough Trump cough), especially with Hydroxychloroquine with Azithromicin, but we’ll get to that in a minute.

    There is no ‘pneumonia’ nor ARDS. At least not the ARDS with established treatment protocols and procedures we’re familiar with. Ventilators are not only the wrong solution, but high pressure intubation can actually wind up causing more damage than without, not to mention complications from tracheal scarring and ulcers given the duration of intubation often required… They may still have a use in the immediate future for patients too far to bring back with this newfound knowledge, but moving forward a new treatment protocol needs to be established so we stop treating patients for the wrong disease.

    The past 48 hours or so have seen a huge revelation: COVID-19 causes prolonged and progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells. People are simply desaturating (losing o2 in their blood), and that’s what eventually leads to organ failures that kill them, not any form of ARDS or pneumonia. All the damage to the lungs you see in CT scans are from the release of oxidative iron from the hemes, this overwhelms the natural defenses against pulmonary oxidative stress and causes that nice, always-bilateral ground glass opacity in the lungs. Patients returning for re-hospitalization days or weeks after recovery suffering from apparent delayed post-hypoxic leukoencephalopathy strengthen the notion COVID-19 patients are suffering from hypoxia despite no signs of respiratory ‘tire out’ or fatigue.

    Here’s the breakdown of the whole process, including some ELI5-level cliff notes. Much has been simplified just to keep it digestible and layman-friendly.

    Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four “hemes”. Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it’s ‘container’. In this way, the iron ion can be ‘caged’ and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

    When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

    Here’s where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is “disassociated” (released). It’s basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

    1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient’s spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you’re treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren’t treating the root cause; the patient’s lungs aren’t ‘tiring out’, they’re pumping just fine. The red blood cells just can’t carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the **** is about to hit the fan for a particular patient or not.

    2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain “iron homeostasis”, 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons… it’s just too much iron and it begins to overwhelm your lungs’ countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it’s always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does… EVERY. SINGLE. TIME.

    — — — — — — — — — — — — -

    Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can’t handle, and your organs are being starved of o2 without their constant stream of deliveries from red blood cell’s hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its ‘iron vault’. Only its getting overwhelmed too. It’s starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out “help, I’m taking damage!” by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the **** is about to hit the fan for a particular patient or not.

    Eventually, if the patient’s immune system doesn’t fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what’s left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don’t have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.

    The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you’re just hoping the patient’s immune system will work its magic in time. The root of the illness needs to be addressed.

    Best case scenario? Treatment regimen early, before symptoms progress too far. Hydroxychloroquine (more on that in a minute, I promise) with Azithromicin has shown fantastic, albeit critics keep mentioning ‘anecdotal’ to describe the mountain, promise and I’ll explain why it does so well next. But forget straight-up plasma with antibodies, that might work early but if the patient is too far gone they’ll need more. They’ll need all the blood: antibodies and red blood cells. No help in sending over a detachment of ammunition to a soldier already unconscious and bleeding out on the battlefield, you need to send that ammo along with some hemoglobin-stimulant-magic so that he can wake up and fire those shots at the enemy.
    The story with Hydroxychloroquine

    All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight ‘bad orange man’ at the cost of thousands of lives. Shame on them.

    How does chloroquine work? Same way as it does for malaria. You see, malaria is this little parasite that enters the red blood cells and starts eating hemoglobin as its food source. The reason chloroquine works for malaria is the same reason it works for COVID-19 — while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin. The same mechanism that stops malaria from getting its hands on hemoglobin and gobbling it up seems to do the same to COVID-19 (essentially little snippets of DNA in an envelope) from binding to it. On top of that, Hydroxychloroquine (an advanced descendant of regular old chloroquine) lowers the pH which can interfere with the replication of the virus. Again, while the full details are not known, the entire premise of this potentially ‘game changing’ treatment is to prevent hemoglobin from being interfered with, whether due to malaria or COVID-19.

    No longer can the media and armchair pseudo-physicians sit in their little ivory towers, proclaiming “DUR so stoopid, malaria is bacteria, COVID-19 is virus, anti-bacteria drug no work on virus!”. They never got the memo that a drug doesn’t need to directly act on the pathogen to be effective. Sometimes it’s enough just to stop it from doing what it does to hemoglobin, regardless of the means it uses to do so.

    Anyway, enough of the rant. What’s the end result here? First, the ventilator emergency needs to be re-examined. If you’re putting a patient on a ventilator because they’re going into a coma and need mechanical breathing to stay alive, okay we get it. Give ’em time for their immune systems to pull through. But if they’re conscious, alert, compliant — keep them on O2. Max it if you have to. If you HAVE to inevitably ventilate, do it at low pressure but max O2. Don’t tear up their lungs with max PEEP, you’re doing more harm to the patient because you’re treating the wrong disease.

    Ideally, some form of treatment needs to happen to:

    Inhibit viral growth and replication. Here plays CHQ+ZPAK+ZINC or other retroviral therapies being studies. Less virus, less hemoglobin losing its iron, less severity and damage.
    Therapies used for anyone with abnormal hemoglobin or malfunctioning red blood cells. Blood transfusions. Whatever, I don’t know the full breadth and scope because I’m not a physician. But think along those lines, and treat the real disease. If you’re thinking about giving them plasma with antibodies, maybe if they’re already in bad shape think again and give them BLOOD with antibodies, or at least blood followed by plasma with antibodies.
    Now that we know more about how this virus works and affects our bodies, a whole range of options should open up.
    Don’t trust China. China is ASSHOE. (disclaimer: not talking about the people, just talking about the regime). They covered this up and have caused all kinds of death and carnage, both literal and economic. The ripples of this pandemic will be felt for decades.

    Fini.

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