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Thread: Technological advances that will directly affect you in the next 2 years

  1. Link to Post #201
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    Default Re: Technological advances that will directly affect you in the next 2 years

    They say 10 years.. I think 2 or less (especially in light of the above human trials)

    Quote Scientists reverse ageing in mammals and predict human trials within 10 years
    An end to grey hair and crows-feet could be just 10 years away after scientists showed it is possible to reverse ageing in animals.

    Using a new technique which takes adult cells back to their embryonic form, US researchers at the Salk Institute in California, showed it was possible to reverse ageing in mice, allowing the animals to not only look younger, but live for 30 per cent longer.

    The technique involves stimulating four genes which are particularly active during development in the womb. It was also found to work to turn the clock back on human skin cells in the lab, making them look and behave younger.Scientists hope to eventually create a drug which can mimic the effect of the found genes which could be taken to slow down, and even reverse the ageing process. They say it will take around 10 years to get to human trials.

    "Our study shows that ageing may not have to proceed in one single direction," said Dr Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory. “With careful modulation, aging might be reversed.

    "Obviously, mice are not humans and we know it will be much more complex to rejuvenate a person. But this study shows that ageing is a very dynamic and plastic process, and therefore will be more amenable to therapeutic interventions than what we previously thought."



    Scientists have known for some time that the four genes, which are known collectively as the Yamanaka factors, could turn adult cells back to their stem cell state, where they can grow into any part of the body.

    But it was always feared that allowing that to happen could damage organs made from the cells, and even trigger cancer.

    However, it was discovered that stimulating the genes intermittently reversed ageing, without causing any damaging side effects.

    In mice with a premature ageing disease, the treatment countered signs of ageing and increased their lifespan by 30 per cent. If it worked similarly in humans it could allow people to live until more than 100 years old. In healthy mice it also helped damaged organs to heal faster.



    "In other studies scientists have completely reprogrammed cells all the way back to a stem-cell-like state," says co-first author Pradeep Reddy, also a Salk research associate.

    "But we show, for the first time, that by expressing these factors for a short duration you can maintain the cell's identity while reversing age-associated hallmarks."

    The breakthrough could also help people stay healthier for longer. The ageing population means that the risk of developing age-related diseases, such as dementia, cancer and heart disease also rises. But if the body could be kept younger for longer then it could prevent many deadly diseases for decades.
    http://www.telegraph.co.uk/science/2...trials-within/
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  3. Link to Post #202
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Graphene is very exciting, but until now, very hard to mass produce...

    This will rapidly increase tech that uses graphine if this is as viable as it seems.
    Quote Physicists inadvertently discover a way to mass-produce graphene

    Cheaper graphene will drive research into the wonder material, with implications extending from increased battery capacity to medical breakthroughs, and beyond.
    By this point, you’ve almost certainly heard of graphene: the ultra-strong, ultra-versatile wonder material that can seemingly do no wrong. But while graphene has a wealth of potentially transformative use-cases, one problem it has had until now is that it can’t be easily and cheaply mass-produced.
    That may have changed courtesy of a breakthrough at Kansas State University, where physicists have inadvertently discovered a way to mass-produce graphene using nothing more complex than hydrocarbon gas, oxygen, and a spark plug.
    The method, which has now been patented, involves oxygen and either acetylene or ethylene gas being placed into a chamber, with the spark plug then prompting a contained detonation that produces the graphene in bulk.
    Lead inventor Professor Chris Sorensen described the discovery to Digital Trends as “serendipity” striking. “We got lucky,” he said — noting that the discovery was a fortunate byproduct of work being done into carbon soot aerosol gels. Nonetheless, it is a particularly exciting step forward,
    “We’ve looked at what other people have achieved with synthetic methods and we feel our method has a number of advantages,” Professor Sorensen said. “The biggest of those is simplicity. All we have to do is to fill a chamber with some oxygen and hydrocarbon, and then use a detonation. We don’t need a catalyst, there are no nasty chemicals, and it looks scaleable. We think it’s a very nice process.”
    As noted, graphene has a range of incredibly exciting applications — extending from potentially improving smartphone battery life to acting as a material for future wearable tech, or even detecting cancer in the human body. There are plenty of labs around the world doing this exciting work, and hopefully now they’ll have a ready supply to carry it out with.
    “I’m not a graphene physicist, I’m an aerosol scientist,” Sorensen said, self-effacingly. “I feel a bit like I’ve adopted a wolf. The wolf loves me and I love the wolf, so I’m going to keep her, but it’s not my area of expertise. It would be great to license this stuff, and we’re already getting some interest from people about that.”


    http://www.digitaltrends.com/cool-te...cing-graphene/
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    Default Re: Technological advances that will directly affect you in the next 2 years

    So update on this..... if it was really "super stable" as predicted it should still be there IMO.. This could mean the predictions were wrong or they did not actually create metallic hydrogen.

    Quote Posted by TargeT (here)
    Harvard researchers created solid metallic hydrogen in the lab and studied it


    And now:



    Quote World's only piece of a metal that could revolutionise technology has disappeared, scientists reveal

    Exclusive: Harvard University physicists say first-ever piece of metallic hydrogen on Earth has been lost after catastrophic failure of diamond holding it under enormous pressure
    http://www.independent.co.uk/news/sc...-a7593481.html
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    Default Re: Technological advances that will directly affect you in the next 2 years

    too bad, it sounded promising

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  9. Link to Post #205
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Instant, range independent communication? "bandwidth" will probably not be a word most people know (again) in the near future.

    Quote Scientists Achieve Direct Counterfactual Quantum Communication For The First Time

    Quantum communication is a strange beast, but one of the weirdest proposed forms of it is called counterfactual communication - a type of quantum communication where no particles travel between two recipients.
    Theoretical physicists have long proposed that such a form of communication would be possible, but now, for the first time, researchers have been able to experimentally achieve it - transferring a black and white bitmap image from one location to another without sending any physical particles.

    If that sounds a little too out-there for you, don't worry, this is quantum mechanics, after all. It's meant to be complicated. But once you break it down, counterfactual quantum communication actually isn't as bizarre as it sounds.
    First up, let's talk about how this differs from regular quantum communication, also known as quantum teleportation, because isn't that also a form of particle-less information transfer?
    Well, not quite. Regular quantum teleportation is based on the principle of entanglement - two particles that become inextricably linked so that whatever happens to one will automatically affect the other, no matter how far apart they are.
    This is what Einstein referred to as "spooky action at a distance", and scientists have already used it to send messages over vast distances.
    But that form of quantum teleportation still relies on particle transmission in some form or another. The two particles usually need to be together when they're entangled before being sent to the people on either end of the message (so, they start in one place, and need to be transmitted to another before communication can occur between them).
    Alternatively, particles can be entangled at a distance, but it usually requires another particle, such as photons (particles of light), to travel between the two.
    Direct counterfactual quantum communication on the other hands relies on something other than quantum entanglement. Instead, it uses a phenomenon called the quantum Zeno effect.
    Very simply, the quantum Zeno effect occurs when an unstable quantum system is repeatedly measured.
    In the quantum world, whenever you look at a system, or measure it, the system changes. And in this case, unstable particles can never decay while they're being measured (just like the proverbial watched kettle that will never boil), so the quantum Zeno effect creates a system that's effectively frozen with a very high probability.
    If you want to delve a little deeper, the video below gives a great explanation:

    Counterfactual quantum communication is based on this quantum Zeno effect, and is defined as the transfer of a quantum state from one site to another without any quantum or classical particle being transmitted between them.
    This requires a quantum channel to run between two sites, which means there's always a small probability that a quantum particle will cross the channel. If that happens, the system is discarded and a new one is set up.
    To set up such a complex system, researchers from the University of Science and Technology of China placed two single-photon detectors in the output ports of the last of an array of beam splitters.
    Because of the quantum Zeno effect, the system is frozen in a certain state, so it's possible to predict which of the detectors would 'click' whenever photons passed through. A series of nested interferometers measure the state of the system to make sure it doesn't change.
    It works based on the fact that, in the quantum world, all light particles can be fully described by wave functions, rather than as particles. So by embedding messages in light the researchers were able to transmit this message without ever directly sending a particle.
    The team explains that the basic idea for this set up came from holography technology.
    "In the 1940s, a new imaging technique - holography - was developed to record not only light intensity but also the phase of light," the researchers write in the journal Proceedings of the National Academy of Sciences.
    "One may then pose the question: Can the phase of light itself be used for imaging? The answer is yes."
    The basic idea is this - someone wants to send an image to Alice using only light (which acts as a wave, not a particle, in the quantum realm).
    Alice transfers a single photon to the nested interferometer, where it can be detected by three single-photon detectors: D0, D1, and Df.
    If D0 or D1 'click', Alice can conclude a logic result of one or zero. If Df clicks, the result is considered inconclusive.
    As Christopher Packham explains for Phys.org:
    "After the communication of all bits, the researchers were able to reassemble the image - a monochrome bitmap of a Chinese knot. Black pixels were defined as logic 0, while white pixels were defined as logic 1 ...
    In the experiment, the phase of light itself became the carrier of information, and the intensity of the light was irrelevant to the experiment."
    Not only is this a big step forward for quantum communication, the team explains it's technology that could also be used for imaging sensitive ancient artefacts that couldn't surprise direct light shined on them.
    The results will now need to be verified by external researchers to make sure what the researchers saw was a true example of counterfactual quantum communication.
    Either way, it's a pretty cool demonstration of just how bizarre and unexplored the quantum world is.
    http://www.sciencealert.com/scientis...the-first-time
    Last edited by TargeT; 15th May 2017 at 20:03.
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Technology has reached magic level.... "google lens"

    Image searching had finally matured?
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Funny that we don't hear that we have effectively cured HIV, Zika & other "boogy man" diseases all over the news... seems like a big thing right?

    Is cancer next?


    Quote CRISPR kills HIV and eats Zika 'like Pac-man'. Its next target? Cancer

    Researchers paired proteins with a process that amplifies RNA which could be used to detect cancer cells


    HIV has no cure. It’s not quite the implacable scourge it was throughout the 1980s and 1990s, thanks to education, prophylactics, and drugs like PrEP. But still, no cure.Part of the problem is HIV’s ability to squirrel itself away inside a cell’s DNA – including the DNA of the immune cells that are supposed to be killing it. The same ability, though, could be HIV’s undoing. All because of CRISPR. You know, CRIPSR: the gene-editing technique that got everyone really excited, then really sceptical, and now cautiously optimistic about curing a bunch of intractable diseases.

    Last week, a group of biologists published research detailing how they hid an anti-HIV CRISPR system inside another type of virus capable of sneaking past a host’s immune system. What’s more, the virus replicated and snipped HIV from infected cells along the way. At this stage, it works in mice and rats, not people. But as a proof of concept, it means similar systems could be developed to fight a huge range of diseases — herpes, cystic fibrosis, and all sorts of cancers.


    Those diseases are all treatable, to varying degrees. But the problem with treatments is you have to keep doing them in order for them to work. “The current anti-retroviral therapy for HIV is very successful in suppressing replication of the virus,” says Kamel Khalili, a neurovirologist at Temple University in Philadelphia and lead author of the recent research, published in Molecular Therapy. “But that does not eliminate the copies of the virus that have been integrated into the gene, so any time the patient doesn’t take their medication the virus can rebound.” Plus treatments can — and often do — fail.

    Gene therapy has promised to revolutionise medicine since the 1970s, when a pair of researchers introduced the concept of using viruses to replace bad DNA with good DNA. The first working model was tested on mice in the 1980s, and by the 1990s researchers were using gene therapies — with limited success — to treat immune and nutrition deficiencies. Then, in 1999, a patient in a University of Pennsylvania gene therapy trial named Jesse Gelsinger died from complications. The tragedy temporarily skid-stopped the whole field. Gene therapy had been steadily getting its groove back, but the 2012 discovery that CRISPR could make easy, and accurate, cuts on human genes, added more vigor....
    More here: https://www.wired.co.uk/article/crispr-disease-rna-hiv
    Last edited by TargeT; 23rd May 2017 at 12:32.
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    Default Re: Technological advances that will directly affect you in the next 2 years

    I don't know if this is genuine or a concept but it looked 'hunger gamish'.. to me...


    Russia: Next-gen combat suit unveiled at opening of Moscow prototyping centre



    Published on 29 Jun 2017
    A prototype for what's being slated as the next generation combat suit
    was unveiled at the opening of Russia's biggest high-tech prototyping
    centre at the National University of Science and Technology (MISIS) in
    Moscow on Thursday.
    Last edited by Cidersomerset; 30th June 2017 at 18:08.

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    Default Re: Technological advances that will directly affect you in the next 2 years

    Prototype...

    I doubt we'll see this anytime soon, our own power armor systems (US) are still far from a working model.
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  19. Link to Post #210
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Just knowing what to look for is such a huge first step... This is a great discovery!

    Quote Scientists Have Uncovered The Atomic Structure of a Key Alzheimer's Protein For The First Time

    For the first time, scientists have revealed the chemical structure of one of the key markers of Alzheimer's disease, capturing high-resolution images of the abnormal tau protein deposits suspected to be behind Alzheimer's and other neurodegenerative conditions.

    The results will now give scientists an unprecedented glimpse at how these harmful deposits function at a molecular level, and could lead to a number of new treatments to prevent them from forming – and in doing so, help to combat Alzheimer's and dementia.

    "This is a tremendous step forward," says one of the team, Bernardino Ghetti from Indiana University.

    "It's clear that tau is extremely important to the progression of Alzheimer's disease and certain forms of dementia. In terms of designing therapeutic agents, the possibilities are now enormous."

    In the new study, researchers led by the MRC Laboratory of Molecular Biology (LMB) in the UK extracted tau protein filaments from the brain of a deceased patient with a confirmed diagnosis of Alzheimer's disease, and imaged them using a technique called called cryo-electron microscopy (cryo-EM).


    Alzheimer's disease is linked to the build-up of two kinds of abnormal protein deposits – tau filaments, which form inside nerve cells, and amyloid beta proteins, which builds up outside cells.

    In healthy brains, tau acts as a stabiliser, but when the proteins become defective, they can form into bundles of tangled filaments, which are thought to impede communication between brain cells, leading to the neurodegeneration and reduced cognitive ability seen in conditions like Alzheimer's disease.
    http://www.sciencealert.com/scientis...the-first-time
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Interesting article it will be longer than 2 years before public service but
    it has done its first successful test of the concept.....

    'Our own sky in a tube’: Groundbreaking vehicle enters phase II of testing



    Published on 14 Jul 2017
    The groundbreaking Hyperloop One vehicle has successfully completed its first test,
    using magnetic levitation technology. Its goal is to create the first near-supersonic
    travel system and prove the concept works. RT America’s Brigida Santos reports

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    Default Re: Technological advances that will directly affect you in the next 2 years

    Could This Hologram Headset Replace Your Cubicle?



    Published on 18 Jul 2017
    San Francisco startup Meta is trying to liberate the workplace of computer monitors
    trading them in for its augmented reality headsets. Bloomberg Technology's Selina
    Wangdelves into the possibilities of an office without screens.

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    Default Re: Technological advances that will directly affect you in the next 2 years

    Quote Nanomachines that drill into cancer cells killing them in just 60 seconds developed by scientists

    The tiny spinning molecules are driven by light, and spin so quickly that they can burrow their way through cell linings when activated.

    In one test conducted at Durham University the nanomachines took between one and three minutes to break through the outer membrane of prostate cancer cell, killing it instantly.
    More here:http://www.telegraph.co.uk/science/2...nds-developed/
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Almost there, once we get techniques like this down the world will shift dramatically as huge stumbling blocks will be removed from the concept to product manufacturing steps.


    Quote 3D printing doubles the strength of stainless steel

    3D printing has taken the world by storm, but it currently works best with plastic and porous steel—materials too weak for hard-core applications. Now, researchers have come up with a way to 3D print tough and flexible stainless steel, an advance that could lead to faster and cheaper ways to make everything from rocket engines to parts for nuclear reactors and oil rigs.

    Stainless steel was first invented nearly 150 years ago, and it remains widely popular today. It’s made by melting conventional steel—itself a combination of iron and carbon (and sometimes other metals like nickel)—and adding in chromium and molybdenum, which prevent rust and corrosion. A complex series of cooling, reheating, and rolling steps gives the material a microscopic structure with tightly packed alloy grains and thin boundaries between the grains that create a cell-like structure. When the metal is bent or stressed, planes of atoms in the grains slide past one another, sometimes causing crystalline defects to connect with each other—producing fractures. But strong boundaries can halt these defects, making the material tough, yet still flexible enough to be formed into a desired shape.

    3D printing researchers have long tried to reproduce this structure. Their setup starts with a powdery layer of metal alloy particles laid on a flat surface. A computer-controlled, high-powered laser beam then advances back and forth across the surface. Particles hit by the laser melt and fuse together. The surface then drops down a step, another layer of powder is added, and the laser heating process repeats, binding the newly melted material to the layer below. By repeating this tier-by-tier addition, engineers can build complex shapes, such as rocket engines.
    The problem has been that, on a microscopic level, printed stainless steels are usually highly porous, making them weak and prone to fracture. “The performance has been awful,” says Yinmin “Morris” Wang, a materials scientist at Lawrence Livermore National Laboratory in California. Several years ago, Wang and his colleagues came up with an approach for using lasers and a rapid cooling process to fuse metal alloy particles together in a dense, tightly packed structure.

    Now, they’ve extended that work by designing a computer-controlled process to not only create dense stainless steel layers, but to more tightly control the structure of their material from the nanoscale to micron scale. That allows the printer to build in tiny cell wall–like structures on each scale that prevent fractures and other common problems. Tests showed that under certain conditions the final 3D printed stainless steels were up to three times stronger than steels made by conventional techniques and yet still ductile, the scientists report today in Nature Materials.

    “What they have done is really exciting,” says Rahul Panat, a mechanical engineer at Carnegie Mellon University in Pittsburgh, Pennsylvania. What’s more, Panat says, is that Wang and his colleagues used a commercially available 3D printer and laser to do the work. That makes it likely that other groups will be able to quickly follow their lead to make a wide array of high-strength stainless steel parts for everything from fuel tanks in airplanes to pressure tubes in nuclear power plants. And that, in turn, will likely only increase the growing fervor over 3D printing.
    http://www.sciencemag.org/news/2017/...less-steel?mwh
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Young people's blood plasma appears to heal alzheimer's, and we are learning the differences between the two so "old" blood can be filtered to the level of "young" blood.


    Makes you wonder about the vampire myths, eh?

    Quote Could Blood Plasma Be The Fountain Of Youth?
    SAN FRANCISCO (CBS SF) — Blood has always been known as “the Gift of Life” and a growing number of Bay Area researchers are currently trying to isolate a factor in blood that may turn back the hands of time.

    “We don’t know how soon we’re going to defeat aging,” proclaimed Aubrey de Grey. “We should be able to keep people truly in a youthful state of health, no matter how long they live and that means the risk of death will not rise.”

    De Grey is the Chief Science Officer and Co-founder of the SENS Research Foundation in Mountain View. He believes we can grow biologically younger.

    “The risk of death will remain the risk of death from causes other than aging — like being hit by a truck,” explained De Grey.SENS funds a dizzying array of projects, research and clinical trials. The Bay Area is packed with bio scientists looking at solving the healthy longevity puzzle.

    Several startups are looking at blood, specifically the pale yellow fluid in blood called plasma.

    “Plasma transfusions are big hot property right now,” said De Grey.

    At the biotech company Alkahest in San Carlos, biotech scientists analyzed plasma samples donated by the young and the old. They were astonished.

    We have actually now for the first time discovered that there are hundreds of proteins that change with aging,” explained the CEO and Chairman Karoly Nicolich.

    Young plasma is awash in special proteins that rejuvenate tissues

    Very old mice injected with young plasma returned to a younger state of being. Scientists discovered how they sprouted newborn neurons in a part of the brain critical for memory and learning

    “It’s pretty dramatic,” remarked Alkahest neuroscientist Sakura Minami.Stanford scientists are now testing the method in humans.

    On November 5, Dr. Sharon Sha, the lead investigator of the trial and neurologist, reported some results at the 10th annual Clinical Trial on Alzheimer’s Disease conference in Boston.

    In a small early phase clinical study, the scientists infused young plasma into 18 patients with mild to moderate Alzheimer’s Disease

    The goal: to see if the treatment is safe

    “We found that it was safe and feasible to administer infusions of young plasma weekly,” reported Dr. Sha.

    But there was also an unexpected surprise said Dr. Sha. She recounted how researchers detected some signs suggesting the patients were getting better

    “We found an improvement on two measures of functional ability,” reported Dr. Sha.

    Larger studies need to be conducted before any conclusions can be reached,

    Even so, Dr. Sha has developed a new found appreciation for blood.

    “It’s all very exciting that there can be components in blood that can be healing.” said the Stanford neurologist.

    Over at U.C. Berkeley, researchers are exploring a different approach

    “There is something in the old blood”, said Professor Irina Conboy.

    Conboy is a bioengineer and researcher at Cal. Along with her husband Michael Conboy, they are exploring how aging is simply not a progressions of time. They found it could go back and it can go forward experimentally.

    They believe the answer is not mixing young plasma into the veins of older individuals, but to recalibrate the older blood of the older individuals.

    “We know that there is bad stuff that accumulates in blood, in the blood of old people. So we’d like to identify those, pick out the most essential ones. and remove them.” explained Professor Michael Conboy

    The Conboys explained how various proteins, peptides, and other molecules accumulate in our blood over time and as we age. The higher the levels of certain deleterious proteins, the more likely a big problem. It’s kind of like adding salt to a favorite dish. Add too much, and it makes the dish inedible. Too high a level of certain bad stuff in the blood, and our stem cells – which repairs our tissues – go to sleep and no longer work to repair parts of our body.

    They propose filtering out levels of the protein in the blood to more youthful levels, and replenishing some of the beneficial proteins that decline in old age. That appears to wake up stem cells in animal studies, and the animal returns to a more youthful state: the heart, liver, lungs, skin, bones all become more youthful.

    “You can have the person’s own blood being purified and rejuvenated and returned very safely to the same person in the state when the person was 20 years old.” declared Professor Irina Conboy.

    They are currently working on a filtering device.

    And while much more research is needed to understand if these therapies can turn back the clock, that hasn’t stopped some folks from charging ahead.

    In San Francisco, a clinic associated with Ambrosia will give you a young plasma transfusion for $8,000.

    Dr. Jesse Karmazin is the founder and CEO of Ambrosia.

    “There are certainly tech folks from Silicon Valley signing up, there are pretty much people from most states, people from overseas people from Europe and Australia have come to be treated.” said Karmazin, who is a medical doctor.
    Last edited by TargeT; 7th November 2017 at 14:16.
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    Default Re: Technological advances that will directly affect you in the next 2 years

    Lets also remember that nature has some wonderful technologies that can help us eliminate manmade carcinogens:

    Quote To many, it has long seemed hopeless that independent farmers could stand a chance under a Monsanto monopoly. Paul Stamets is a man with a plan: A David ready to fight the Monsanto Goliath. Except Stamets isn’t throwing stones; he’s growing mushrooms.

    In 2006, Stamets obtained a patent that’s being hailed as revolutionary, with claims that it could undermine Monsanto’s grip on the farming industry.

    Stamets is an eminent mycologist, a person who studies fungi and its uses. “Fungi are the grand recyclers of the planet,” he says in one media report. They have the potential to regenerate ecological systems and “re-green” the planet. Before taking on pesticides, he developed mycotechnology with petroleum-eating mushrooms that clean up oil spills.

    SMART pesticides, a mycotechnology he successfully patented in 2006, wouldn’t just strike a blow to Monsanto — he suggests that using mycopesticides could fuel an ecological revolution, restoring and rehabilitating polluted ecological sites. So-called “SMART” pesticides work via “sporulation,” sprouting fungi in the insects that consume them. Once the first batch of insects dies, other pests are driven away from the area.
    https://backtotheroots.com/blogs/btt...-down-monsanto

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    Default Re: Technological advances that will directly affect you in the next 2 years

    Quote Posted by JoefromtheCarolinas (here)
    Lets also remember that nature has some wonderful technologies
    Certainly, and mushroom uses is a great introductory topic.

    For example:

    Quote Study Finds Mushrooms May Have ‘Fountain Of Youth’ Benefits
    STATE COLLEGE, Pa. — Mushrooms may make our favorite pizza and pasta dishes taste delightfully better, but it turns out they may help keep our brains and hearts younger too. A new study finds that some of our favorite toadstools may have high concentrations of antioxidants with anti-aging benefits.

    Researchers at Penn State analyzed the chemical composition of a wide variety of types of mushrooms, finding that many contained high levels of ergothioneine and glutathione, both of which are important antioxidants.

    “What we found is that, without a doubt, mushrooms are highest dietary source of these two antioxidants taken together, and that some types are really packed with both of them,” says lead researcher Robert Beelman in a university news release.

    It is widely accepted that the human body’s chemical process of converting food into energy produces free radicals, which can cause damage to cells, protein, and DNA, the researchers explain.

    “There’s a theory — the free radical theory of aging — that’s been around for a long time that says when we oxidize our food to produce energy there’s a number of free radicals that are produced that are side products of that action and many of these are quite toxic,” says Beelman.

    Eventually, an accumulation of free radicals can lead to chronic disease and illness, including “cancer, coronary heart disease, and Alzheimer’s,” he adds. Ergothioneine and glutathione can help control those free radicals.

    Beelman and his team found that the quantity of antioxidants in certain species varied, with the porcini species, which is a wild variety, carrying the highest amount of both ergothioneine and glutathione.

    “This species is really popular in Italy where searching for it has become a national pastime,” Beelman says.
    Meanwhile, some garden-variety types of mushroom, such as the white button, had fewer antioxidants, although more than most foods.

    Interestingly, there was little evidence that cooking mushrooms significantly changed the composition of their antioxidants, particularly as it pertained to ergothioneine.

    Future research could look into the ability of ergothioneine and glutathione to help prevent neurodegenerative disease, such as Parkinson’s and the aforementioned Alzheimer’s, Beelman suggests.

    “It’s preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinson’s Disease and Alzheimer’s,” Beelman notes.

    Although the relationship between mushroom consumption and neurodegeneration may be one of correlation, instead of causation, it would only take about five button mushrooms a day for Americans to close the gap, he adds.

    The study’s findings were published last month the journal Food Chemistry.
    https://www.studyfinds.org/mushrooms...-antioxidants/
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    Default Re: Technological advances that will directly affect you in the next 2 years

    This is a big step for making CRISPR treatments more predictable and consistent.

    Quote CRISPR Can Now Edit Genes Using Nanoparticles Instead of Viruses
    The new delivery mechanism completely turned off a gene responsible for high cholesterol in mice.

    Since its was first harnessed by scientists in 2013, the natural gene-editing technology known as CRISPR has sparked a designer baby controversy, dreams of ending hereditary diseases, and fears of sophisticated biological terrorism. Yet for all of CRISPR’s peril and promise, figuring out a way to effectively deliver the system to the target DNA has remained a significant technical hurdle.

    Usually, a CRISPR system—which consists of an enzyme called Cas9 that cuts out a portion of a target DNA strand, as well as a short strand of RNA that guides the enzyme to its target—catches a ride through the body in a virus. This is a less than ideal solution because patients receiving a CRISPR treatment can quickly develop, or may already possess, antibodies that would destroy it.

    As detailed today in Nature Biotechnology, a team of researchers at MIT has created a highly effective, non-viral solution: a nanoparticle system that can deliver CRISPR to target genes. Moreover, the nanoparticle CRISPR-delivery system was able to completely turn off a gene responsible for high cholesterol level when administered to mice.

    The group was led by MIT research scientist Hao Yin and associate professor of chemical engineering Daniel Anderson, both of whom have made ground-breaking discoveries in the science of gene editing in recent years.

    In 2014, Yin, Anderson, and their colleagues at MIT became the first to cure a disease in an adult animal using CRISPR. In this case, it was a liver disease called tyrosinemia and the “patients” were adult mice. The problem, however, was this CRISPR method was dependent on viral delivery, as well as a high pressure injection, which could cause damage to the liver.Anderson and Yin further modified this approach in 2016 by encasing the Cas9 enzyme in a lipid nanoparticle.

    These are particles existing on the nanoscale that basically act like synthetic cells, protecting their contents with a wall of fatty material known as lipids.

    The nanoparticles obviated the need for a high-pressure viral delivery system for Cas9, although the guiding RNA strand still required a virus for delivery. Deploying single strands of RNA is a difficult problem since our body associates them with viral infections. This can prompt the body to trigger certain immune responses that can result in the degradation of the RNA, rendering it useless.

    One solution to this problem that has been explored in RNA-based medicines is to modify the RNA so that it doesn’t trigger an immune response. Things get a bit tricker when modifying RNA for CRISPR, since the modified RNA still needs to be able to interface with the Cas9 enzyme.

    In their new research, Anderson and Yin worked on modifying the guide RNA so that it wouldn’t trigger the body’s immune system as it worked its way toward its target in a nanoparticle, while still being able to link up with the Cas9 enzyme. As they found in their research, they could modify up to 70 percent of the RNA before it was unable to bind to the Cas9 enzyme as a CRISPR system.

    Importantly, the ability to use chemically modified RNA in the CRISPR system meant that a virus was no longer needed as a host for the guide RNA. It could instead be encased in a synthetic nanoparticle.

    The guide RNA is programmed to seek out specific genes in the liver by reversing the genetic code found in a target strand of DNA. Once it locates this target DNA sequence, the Cas9 enzyme effectively splits the double helix to allow the guide RNA to bind to the DNA. If it’s a good match, this portion of the helix is excised from DNA strand. Usually, the DNA strand tries to repair itself, at which point the CRISPR system does its thing again. This process is repeated until the DNA no longer repairs itself, at which point the targeted gene has effectively been turned off.

    In their new research, Anderson and his colleagues at MIT looked at a handful of different genes for their CRISPR system, but they mostly focused on PCSK9, a gene that produces a protein responsible for regulating cholesterol levels.

    This gene is also responsible for hypercholesterolemia, or high cholesterol, which a genetic condition that affects about 1 in 500 people. High cholesterol significantly increases the risk of strokes and heart disease, and while a new suite of drugs targeting PCSK9 have proven to be effective, these drugs must be taken daily for the rest of a patient’s life.

    “PCSK9 is an exciting and clinically relevant target for the treatment of hypercholesterolemia as there are some people who genetically get these incredibly high levels of cholesterol,” Anderson told me on the phone. “We reasoned that it may be possible to permanently inactivate this gene using a nanoparticle and that might provide a lifetime of therapy for patients.”

    When Anderson and Yin injected these CRISPR-carrying nanoparticles into the livers of mice, the CRISPR system was able to eliminate the PCSK9 gene in 80 percent of their liver cells. This resulted in a 35 percent drop in cholesterol in treated mice. According to Anderson, this same technique may be used to treat other liver diseases, and may be slightly modified for use treating diseases in other body tissues.

    It’s uncertain how long it will be before nanoparticle CRISPR treatments like the one pioneered by Anderson and Yin see widespread clinical use in humans.

    For now, the nanoparticle technology will likely remain confined to non-human experiments, if for no other reason than CRISPR is still quite error prone. Although scientists are also exploring alternative gene-editing technologies that are more accurate than CRISPR, Anderson believes this new nanoparticle delivery system marks a significant step toward the medical adoption of CRISPR in humans.

    “Nanoparticles like these have real potential to treat people with diseases,” Anderson said. “My hope is that these types of formulations really do end up helping people, that’s what really motivates us.”
    https://motherboard.vice.com/en_us/a...rticle-mit-rna
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    Default Re: Technological advances that will directly affect you in the next 2 years

    British inventor sets jet suit record



    Published on 9 Nov 2017
    Richard Browning sets a world record for the fastest speed in a body controlled jet engine powered suit.

    'Iron man' flight sets first world record - BBC News
    https://www.youtube.com/watch?v=VBTdxGQnWTM
    http://www.bbc.co.uk/news/av/technol...t-world-record

    ===========================================
    ===========================================



    Now computers are writing perfectly acceptable pop songs

    By Mark Savage
    BBC Music reporter
    10 November 2017

    Taryn Southern is making an entire album co-written by artificial intelligence software

    http://www.bbc.co.uk/news/entertainment-arts-41935971

    ==========================================
    ==========================================


    taxis Uber alles: NASA pairs with ride-hailing co. for space-age cabs

    https://www.youtube.com/watch?v=4cFhtuGocQQ
    Published on 9 Nov 2017
    The present may be about to crash into “The Jetsons” prediction of the future:
    NASA and Uber have paired up to design flying taxis that could hit the skies
    above Los Angeles, California in the next five years. RT America’s Natasha
    Sweatte heads back to the future to take a look.

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    Default Re: Technological advances that will directly affect you in the next 2 years

    Not sure if this is good news, or just a Idiocracy coming true....


    Sounds like they are stimulating targeted stemcell production as well as blocking a protein binding... pretty cool with some great "side" benefits.

    Quote Korean scientists discover potential cure for baldness

    Male pattern baldness continues to be the plight for men around the world, but a group of South Korean scientists may have found the cure.

    Researchers from Yonsei University in Seoul have unraveled a potential drug candidate that aggressively targets the protein that blocks hair follicle growth.

    The exciting discovery, as per The Korea Herald, may soon pioneer new forms of hair-loss treatments, which are currently limited to growth acceleration and delay of hair loss, rather than complete regeneration.

    Funded by the Korean Ministry of Science, a team led by professor Choi Kang-yell has come up with a protein called CXXC-type zinc finger protein 5, which can bind the disheveled protein that triggers hair loss.

    “This newly developed substance is a first-in-class drug candidate. It is expected to become a treatment for not only hair loss and baldness but also for regenerating damaged skin tissue,” Choi explained.

    Through these findings, the group managed to develop the biochemical substance, PTD-DBM, which prevents CXXC from binding with the badness-causing protein.

    “Disrupting the CXXC5-Dishevelled interaction with a competitor peptide activated the Wnt/β-catenin pathway and accelerated hair regrowth and wound-induced hair follicle neogenesis,” an excerpt from the paper “Targeting of CXXC5 by a Competing Peptide Stimulates Hair Re-growth and Wound-Induced Hair Neogenesis” read.

    Meanwhile, Professor Choi clarified that their findings were different from existing studies like MSD’s Propecia (finasteride), which simply slows down hair loss and cannot be applied to subjects with no hair follicles left.

    The group is also aiming to forego typical side effects of hair-loss treatments, including impotence and abnormal ejaculation, caused by hormonal imbalances.

    The group’s complete findings were published in the Journal of Investigative Dermatology last month.
    Read more: https://technology.inquirer.net/6959...#ixzz4zfHUlEdU

    Another take here:
    http://www.esquire.co.uk/life/news/a...-for-baldness/
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