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Thread: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

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    Slovenia Avalon Member spizella's Avatar
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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    My astrologist said me, that this was planed. They are using NEPTUNE power to use viruses, bacteria and so on. Right now the power is concentrated in Africa.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Emirates Airlines cancels flights to Guinea

    Due to the Ebola present in West Africa, Emirates (Dubai) has said it will no longer fly to Guinea in efforts to stop the potential spread of Ebola.

    They are the first major international air carrier to suspend all flights to the virus affected region.

    ref: http://www.independent.co.uk/news/wo...n-9644770.html

    “We apologise for any inconvenience caused to our customers, however the safety of our passengers and crew is of the highest priority and will not be compromised,” a statement read.

    The airline, which does not operate services to Sierra Leone or Liberia, said it would continue to provide flights to Dakar in Senegal. It said further decisions on West Africa would be “guided by the advice and updates from the government and international health authorities”.

    This was their page describing flights to Guinea:
    http://www.emirates.com/us/english/d...kry/index.aspx

    - Conakry

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    Exclamation Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Mapp is what MSM is saying is the company who produced the experimental antibody treatment Dr. Brantly received. Initial data was circulated (for some reason), across the internet that the treatment was from a serum created from a child that survived. It is strange that such data was circulated IF MAPP was developing a countermeasure for a bioweapon called EBOLA Zaire (strain)..

    ref: http://projectavalon.net/forum4/show...l=1#post861191 - this is the post where I discuss a bit more of this issue.. SPIN or information.

    DTRA has not said that Dr. Brantly was treated with the MAPP monoclonal antibody treatment.

    DTRA PAGES on Bio-Weapons:

    http://www.dtra.mil/missions/Chemica...fenseHome.aspx

    "DTRA and SCC-WMD are actively engaged in efforts to defend against chemical and biological weapons. Our work in this arena has global reach, impacting everyone from our men and women serving on the frontlines to American citizens in the heartland."

    "Defending the country against chemical and biological threats presents a wide variety of challenges. DTRA works to tackle these challenges by partnering with interagency organizations such as the Department of Health and Human Services, to prepare for biological and chemical events. In cooperation with DoD and HHS, DTRA is using state-of-the-art technology and executing our first agent-based, high performance computational analysis system, which has resulted in a revolutionary pandemic influenza modeling capability.

    DTRA recently completed part of a significant study that looked at a nine region response effort with multiple interventions. The result of this study will help the U.S. prepare for a possible pandemic, and is a perfect example of DTRA’s Reachback capabilities, technical expertise and the value DTRA provides to other departments and agencies."

    DTRA talks about in this PDF, how they feel there can be SPECIES transfers of numerous diseases (animals into humans)


    Quote "Horizontal gene transfer (HGT) is a type of gene flow that occurs in bacteria and viruses, which can produce new strains with enhanced virulence and the ability to infect new hosts. Although HGT occurs more frequently in bacteria, several families of viruses (including Poxvirus and Herpesvirus species) are known to have acquired genes from hosts through HGT."
    ED Update - CNN is currently reporting that the DRUG treatment used is TOP SECRET (thereby that is the reason for the disinformation, I suppose if the drug failed). Treating Ebola Zaire if it were a bioweapon's version of it would definitely have the drug security classed.
    Last edited by Bob; 9th October 2015 at 07:32.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    The Vaccine for two Strains of Ebola Virus

    http://www.npr.org/blogs/health/2010...inst-new-virus

    No virus is more feared than Ebola. So scientists were alarmed when a new species of Ebola emerged in Uganda in 2007.

    They worried that the Bundibugyo ebolavirus, as it's called after the township in western Uganda where it was discovered, wouldn't be thwarted by the promising experimental vaccines already being developed against other lethal Ebola species.

    Scientists can't just keep adding new viral species or strains to vaccines. "Generally the more strains you put into a vaccine, the less likely it will work," says vaccine researcher Nancy Sullivan of the National Institute of Allergy and Infectious Diseases.

    But Sullivan and her colleagues have good news. They found that a current experimental vaccine totally protected monkeys against the Bundibugyo bug — even though the new virus wasn't included in the vaccine recipe. Their results appear in the online journal PLoS/Pathogens.

    Importantly, the vaccine did the trick without stimulating any antibodies against the Bundibugyo virus. Protection depended entirely on the other arm of the immune system, called cellular immunity.

    "The dogma is that viruses require an antibody response to prevent the virus from entering the cell," Sullivan says. "This is truly the first time that cell-mediated immunity alone has been shown to be protective against virus infection."

    The vaccine specifically protects against the Zaire and Sudan species of Ebola.

    Both are very different from the new Bundibugyo virus – as much as 43 percent different, in terms of genetic sequences.

    The vaccine contains pieces of the protein-sugar coat (glycoprotein) from the Zaire and Sudan viruses, inserted into a type of common cold virus.

    The cold virus carries the Ebola glycoprotein into cells of the vaccine recipients – in this case four macaques in a maximum-security lab at the U.S. Army Medical Research Institute for Infectious Diseases, or USAMRIID, at Fort Detrick, Maryland.

    Once infected, the monkeys' immune cells chop the Ebola glycoprotein into small pieces and display them on their surface, where they stimulate a response from other immune cells.

    The monkeys got four "priming" shots, followed a year later with a booster shot.

    Four other macaques got no vaccine. All eight animals were inoculated with ordinarily lethal doses of the new Ebola virus.

    The vaccinated animals all survived, and the unvaccinated monkeys all died.

    The researchers will use the new results to "optimize" a vaccine that might eventually be approved for human use. To do that, they'll have to show it works in larger animal studies.

    There's no way to do trials of Ebola vaccines in humans. Unlike, say, a vaccine for HIV, there's no identifiable group of people at risk for Ebola, which tends to pop up unexpectedly when conditions are ripe for the virus to jump from its unknown reservoir – possibly in fruit bats – to nonhuman primates and then humans.

    The Food and Drug Administration has already agreed to accept animal evidence of efficacy for an Ebola vaccine. But to get to that stage, the experimental vaccine needs more support. It could come from a commercial sponsor, the Defense Department or the NIH, but so far that hasn't happened.

    And who would get an Ebola vaccine once it's approved?

    "You would target health care workers and others at risk of being exposed," Sullivan says. "The military in the US and Africa would be another candidate. When there's an Ebola outbreak, everyone scatters. If the military were vaccinated and weren't afraid of infection, they might be better at protecting the borders."

    And in the event of an Ebola outbreak – whether an indigenous epidemic in Africa or as the result of a bioterrorist plot – public health officials would probably use "ring vaccination." That is, everyone around the first victims – family members, health care workers, and possibly everyone in a circumscribed geographic area – would get access to the Ebola vaccine.

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    Exclamation Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    More from USAMRID - this is an amazing document detailing Marburg a much older virus which hit in Marburg Germany (something also which would be classed as a bio-weapon). Marburg Virus is also discussed within this thread.


    Discussed within the PDF something that caught my attention - MERS_nCov effective treatment in this particular serum/vaccine.. THAT for MERS/SARS/nCov to have a link to MARBURG virus really give me the heavie jeevies.. seriously..

    MERS/SARS are respiratory viri spread by droplets, and secretions.. I coughed into the room, and my ma got it, and died from it in a week.. (hospital ignoring that mers was present !! see the MERS thread for details on that one..)

    According to senior author Sina Bavari, the drug, known as BCX4430, protected cynomolgous macaques from Marburg virus infection when administered by injection as long as 48 hours post-infection.

    Bavari and his team at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) also found that BCX4430 protected guinea pigs exposed to Marburg virus by the inhalation route.

    Developed by BioCryst Pharmaceuticals, Inc., BCX4430 also demonstrated activity against a broad range of other RNA viruses, including the emerging viral pathogen Middle East respiratory syndrome coronavirus (MERS-CoV), when tested in cell culture.

    “This study demonstrates the importance of government-industry collaboration,” said COL Erin P. Edgar, commander of USAMRIID. “Developing filovirus medical countermeasures is a top biodefense priority for the United States. When federal assets like USAMRIID team up with cutting-edge partners in private industry, we can make real progress toward achieving that goal.”
    Last edited by Bob; 4th August 2014 at 19:46.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    USAMRIID says the Ebola Treatment can be produced in Tobacco plants (Gene splicing) - report October 2012 (!!)

    It can be reproduced easily, effectively and in mass quantities..


    EMBARGOED FOR RELEASE: CONTACT: Caree Vander Linden
    October 15, 2012 – 3:00 PM Eastern Time (301) 619-2285
    Fort Detrick, Maryland Caree.VanderLinden@us.army.mil

    Mass quantities can be produced in TWO WEEKS !!

    “We were pleased to see how well the humanized mAbs of MB-003 performed,” said Larry Zeitlin, Ph.D., president of Mapp Biopharmaceutical and senior author on the study.

    “We also were pleasantly surprised by the superiority of the plant-derived mAbs compared to the same mAbs produced in traditional mammalian cell culture.”

    "Further improvement in antibody efficacy was developed at Kentucky BioProcessing (KBP).

    "Using a fully automated production system that operates in accordance with good manufacturing practices (GMP), antibody is produced in a tobacco plant system.

    "This new development process significantly decreases the amount of time required for production, increases the quantity of antibody produced, and slashes the cost of manufacturing, according to Barry Bratcher, chief operating officer of KBP and co-author on the PNAS study. “Our GMP facility can generate a new antibody lot in two weeks to rapidly address new threats and new outbreaks,” said Bratcher. "

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    ZMapp ebola treatment License Document information (who makes it who controls it)

    http://www.defyrus.com/images/News-J...Ab-license.pdf


    Toronto, ON - Today Defyrus announced an exclusive, worldwide license to their Ebola
    therapeutic monoclonal antibody (mAb) patent portfolio to Leaf Biopharmaceutical Inc. of San
    Diego, CA. This license expands the commercial relationship between LeafBio and Defyrus who
    have been actively collaborating to drive the commercialization of mAb-based Ebola therapies.

    LeafBio, the commercialization partner of Mapp Biopharmaceutical, had been developing
    proprietary Ebola-specific antibody drug MB-003 in collaboration with the National Institutes of
    Health and the Defense Threat Reduction Agency (DTRA).

    The licensing of Defyrus’ ZMAb antibody portfolio, pioneered at the Public Health Agency of Canada (PHAC) and licensed earlier
    to Defyrus, consolidates the intellectual property of a superior combination mAb drug – termed
    ZMapp™ - which is composed of the best mAbs of MB-003 and ZMAb.

    Under the terms of the exclusive, worldwide license, LeafBio assumes the commercial responsibility for the ongoing development of ZMapp™. The two companies have agreed to an equitable revenue sharing model based on ZMapp™ product sales.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    British Air suspends flights to West Africa due to Ebola.
    5 August 2014

    Update -

    Airlines flying to West Africa are cancelling some flights and offering travel waivers on others due to confirmed reports of Ebola hemorrhagic fever in the area.

    Earlier this week, British Airways said it had cancelled flights to Sierra Leone and Liberia, while Emirates Airline has suspended service to Guinea. Delta Air Lines issued a travel waiver for Abuja, Nigeria; Conakry, Guinea; Freetown, Sierra Leone; Lagos, Nigeria; Monrovia, Liberia; and Port Harcourt, Nigeria through August 15. Passengers can rebook for travel no later than August 31.

    British Airways said the move was ““due to the deteriorating public health situation in both countries.”

    In a message on its website, Delta said that passengers departing from Monrovia, Liberia “may encounter required health screenings by government officials prior to gaining entry to the airport,” adding that passengers may also encounter such screenings upon arrival at Lagos, Nigeria.

    Last week, the Center for Disease Control and Prevention issued an Ebola travel warning, raising its travel health alert to Level 3, the highest level. The agency said that cases of the deadly Ebola virus have been confirmed in Guinea, Liberia, and Sierra Leone, and warned against non-essential travel to these countries. Cases of Ebola have also been confirmed in Nigeria and a Level 2 warning is in effect for that nation.

    Kenya Airways, Gambia Bird and other flights are still flying in and out of Monrovia from and in Ghana.

    Lead African carriers Arik and ASKY recently halted flights to Guinea, Liberia and Sierra Leone.
    Last edited by Bob; 6th August 2014 at 20:49.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Over 900 dead currently - this would qualify for moving to pandemic level.

    http://www.who.int/mediacentre/news/...view-ebola/en/

    WHO to convene special meeting on the Ethical Use of zMapp and other experimental treatments for Ebola

    WHO statement
    6 August 2014

    Early next week, WHO will convene a panel of medical ethicists to explore the use of experimental treatment in the ongoing Ebola outbreak in West Africa. Currently there is no registered medicine or vaccine against the virus, but there are several experimental options under development.

    The recent treatment of two health workers from Samaritan’s Purse with experimental medicine has raised questions about whether medicine that has never been tested and shown to be safe in people should be used in the outbreak and, given the extremely limited amount of medicine available, if it is used, who should receive it.

    Media contact:
    Tarik Jasarevic
    WHO Department of Communications
    Telephone: +41 22 791 50 99
    Mobile: +41 79 367 62 14
    E-mail: jasarevict@who.int

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Saudi suspects death due to Ebola

    Spain said it will accept a patient from the West African outbreak, adding to concerns about the spread of the deadly virus.

    Nigeria reported that a nurse died after treating someone believed to have contracted Ebola in Liberia, and Saudi Arabia reported that a man died, apparently of the virus, after a trip to Sierra Leone.

    The World Health Organization did not immediately confirm the deaths.

    A Spanish priest who contracted the disease in Liberia will be flown to Madrid and become the Europe's first patient from this outbreak, according to the Spanish government.

    Traveling into the Ebola epicenter Sierra Leone 'not able to deal' with Ebola
    WHO said Wednesday that 932 deaths had been reported or confirmed as a result of Ebola through Monday.

    Source CNN

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Spain to accept 75 year old Ebola Patient

    Source

    Ebola coming to Europe

    Miguel Pajares, 75, a Spanish missionary priest working at a hospital in the West African country, will be taken to Spain by a military jet.

    A medically-equipped military jet has been sent to Liberia to repatriate Miguel Pajares, 75, a Spanish missionary priest working at a hospital in the West African country.

    Brother Pajares and his two fellow workers, Chantal Pascaline Mutwamene of Congo and Paciencia Melgar from Equatorial Guinea, belong to the Hospital Order of San Juan de Dios, a Catholic humanitarian group that runs hospitals around the world, and had been helping to treat patients infected with the virus.

    They had been in quarantine since Saturday along with two others – who have since tested negative - following the death of the hospital’s director, Brother Patrick Nshamdze.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Lagos Nigeria is worried.

    Source

    Lagos Pushes for Closure of Borders

    The hospital in Awka had been closed, where the patient who flew in from Liberia died.

    Worried about the spread of the Ebola Virus Disease (EVD) in the West African sub-region, the Lagos State Government has been making efforts to reach out to the federal government to close the nation's borders with neigbouring West African countries for a period until the deadly infection has been brought under control.

    The World Health Organisation (WHO) over the weekend had declared that the EVD had spiralled out of control.

    Sources close to Governor Babatunde Raji Fashola of Lagos State informed THISDAY over the weekend that there were frantic efforts by the governor to contact President Goodluck Jonathan before his departure to the United States on Saturday night to discuss the option of closing the borders with other West African countries.

    The sources however said the president could not be reached before he flew out of the country to Washington DC for the African Leadership Summit due to commence today.

    Although the Minister of Health, Professor Onyebuchi Chukwu, had said the federal government was not contemplating the closure of borders, the Lagos State Government held the view that their closure might become imperative given the reports of the return of bodies of persons suspected to have died from the virus in some neigbouring West African countries.

    "We have a growing number of cases where bodies of relations who may have died of the Ebola disease are being transported home through the borders for burial here in Nigeria, in accordance with the cultural demands of bringing corpses home.

    "We fear that if this is unchecked, it could promote the spread of the infection, especially if the dead persons were victims of the EVD infection," one source close to the governor said.

    Sources in the state further explained that it had become expedient for the federal government to take the effect of the spread of the disease seriously and regard it as a "national security" matter, which should override all other commercial and treaty obligations with Nigeria's West African neighbours. They expressed concern that "should Ebola virus spread in a densely populated city like Lagos, it would be difficult to control".

    The sources added that the federal government would need to reach out to families of EVD victims in neighbouring countries and advise them to suspend bringing home the bodies of relations for burial.

    "They should be educated that it is safer for bodies of EVD victims to be cremated in the countries where they died, and save others the risk of contracting the disease if the bodies are brought back to Nigeria," an aide of the governor said.

    (Hmm. western education is sinful eh? boko haram uses that to keep people uneducated and dying, and now with ebola going pandemic, what is boko going to do, declare it evil spirits or finally face that people require proper education and compassion.. not terror..)

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    Exclamation Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Global international alerts are now being issued in countries around the world.

    CDC (Centers for Disease control) has set alert level to 3, the highest they have for Sierra Leone, Guinea and Liberia.

    Countries (this is not a complete list) have evoked various levels of warning, doctors, hospitals airports to be on the look-out for symptoms.
    • Major entry points in Malaysia under Ebola alert - Kuala Lumpur International Airport
    • Feds are keeping a close eye on passengers arriving at JFK NY
    • Maldives: Health authorities have issued an alert on Ebola and have asked people to take preventive measures against it
    • Nigeria on high alert
    • South Korea's Incheon International airport on high alert
    • MANILA, Philippines – The country's airports are on full alert over all flights
    • East Africa is on high alert
    • India on high alert
    • New Zeland on High alert
    • Australia Immigration and Border control is on high alert
    • Ivory Coast on alert for Ebola
    • Rwanda has deployed medics and installed a temporary clinic at Kigali International Airport following red alerts
    • UK hospitals 'on alert'
    • Ghana MPs issue ebola alert
    • Harry Mwaanga Nkumbula International Airport on alert (Zambia)
    • S Africa remains on alert as Ebola spreads
    • Thailand Alert for Ebola
    • Zimbabwe on Ebola alert
    • The EU is readying itself for any spread of Ebola from West Africa to Europe
    • Ebola: Kenya issues Ebola alert
    • Uganda - The Ministry of Health yesterday set up a screening centre at Entebbe International Airport
    • Cape Verde in red alert against Ebola virus
    • Ebola outbreak: Mali on alert
    • Lebanon on full alert over Ebola
    • France 'on alert' amid Guinea Ebola outbreak
    • HMC: Qatar taking precautions to protect against deadly Ebola outbreak
    • Saudi Arabia has been on alert against the spread of the virus from west Africa
    • Iraq Gov't On High Alert As Threat Of Ebola increases

    Update Country List:
    • Singapore on alert
    • China (Proper) says it will watch for it, but it "can handle" (it) and any infections disease without concern

    Update - Liberia officially in State of Emergency country-wide from the outbreak
    Source

    "The country’s president, Ellen Johnson-Sirleaf, said that the scale of the Ebola outbreak represents a threat to Liberia’s security.

    "The government and people of Liberia require extraordinary measures for the very survival of our state and for the protection of the lives of our people," she said via statement. "I...hereby declare a State of Emergency throughout the Republic of Liberia effective as of Aug. 6, 2014 for a period of 90 days."
    Last edited by Bob; 8th August 2014 at 15:45.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    CFR - Council of Foreign Relations agrees Ebola is out of control


    (that place above is generally wall to wall people in international arrivals Lagos, it's hot and sweaty.. nasty)

    "John Campbell, CFR senior fellow for Africa policy studies and former U.S. ambassador to Nigeria, said Ebola has already had an impact on the economies in the West African nations. "Sierra Leone’s growth rate has been cut by 1%, Campbell said, and more dramatic economic and political consequences are possible.

    "The three countries affected are going through an extremely rapid period of urbanization, Campbell said. Liberia and Sierra Leone are emerging from lengthy civil wars, and rural villagers are packing into urban slums, making quarantine difficult.

    "If the epidemic spreads into Lagos, Nigeria’s largest city and the second-fastest growing city in Africa, it will have “destabilizing consequences,” Campbell said."

    Laurie Garrett, is a CFR's senior fellow for global health.

    There is no strategic plan of how we're going to bring this under control says Laurie Garrett

    Garrett spoke on a conference call with reporters as the second American infected with Ebola in Africa arrived in Atlanta for treatment under strict quarantine, and a day after a patient in New York City was tested for the disease. City health authorities concluded the patient is unlikely to have Ebola.

    “There is no strategic plan of how we’re going to bring this under control,” Garrett said. “What will be the global strategy if this disease shows up elsewhere?”

    ------------------------

    Naw, the airport is not crowded, easy to navigate through there and not be brushing on your traveling companion (or neighbor traveler)..


    more



    Enjoy your stay, (and limit the bushmeat btw)

    Last edited by Bob; 9th October 2015 at 07:33.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Nigeria IS concerned - Nigeria confirmed another five cases of Ebola, the Health Ministry said.

    The CDC says it's not likely the drug ZMapp will become available for patients in West Africa.
    "The product is still in an experimental stage, and the manufacturer reports that there is a very limited supply, so it cannot be purchased and is not available for general use," the CDC said.

    Will we see a WAR over this? Compassionate help being withheld because of bureaucratic HOOPS that have to be jumped through, or is there something deeper here going on?

    Source

    For these DRUG COMPANIES who ROUTINELY test in Africa and India, to with hold such a potential drug at this point for some "excuse" is extremely interesting. WHY.. They do it all the time with drugs, the studies in Africa and India.. WHY NOW with hold?

    OPINION PAGE - THOUGHTS

    Source

    We don't know how quickly ZMapp could be made in large quantities. (see update below).

    If it were to be made available, who should receive it? Some think Ebola doctors and caregivers should, because their survival is essential to treating and quelling the epidemic. This makes sense, but it's not that simple.

    First, it violates the principle of distributive justice: The benefits of the drug are being inequitably distributed, with skilled, economically secure professionals more likely to benefit.

    Also, by what reckoning do we decide that the doctors' role increases their value and dictates they should be given a preferential chance to survive? Distributing the drug through a clinical trial would allow us to know whether and how well the medication works and what caveats might apply.

    Africans must participate in any clinical trial, which would benefit the pharmaceutical company as well as, it's hoped, Ebola victims. This would mean their lives have irreplaceable value, too, in the equation of who should get the drug.

    So, will Africans receive this potentially lifesaving medication?

    A U.N. official suggested that drugs cannot be tested in the middle of an epidemic -- but he is wrong. Such tests are conducted all the time.

    Dr. David Ho tested AIDS drugs in Uganda in the midst of the pandemic, and the meningitis drug Trovan was tested in Kano, Nigeria, in the midst of an epidemic. One of every three industry trials is conducted in developing countries; scientists often point to high disease rates, including epidemics, as a rationale for conducting them there.

    The problem is not testing the drug amid an epidemic. The question is how ethically such trials are conducted.

    Waiting for committee decisions is NOT appropriate. Compassion is important, and the lives of many more people WORLD-WIDE are at stake here.. this pandemic IS out of control.

    UPDATE - HOW LONG to make substantial quantities ? TWO WEEKS.

    “We also were pleasantly surprised by the superiority of the plant-derived mAbs compared to the same mAbs produced in traditional mammalian cell culture.”

    "Further improvement in antibody efficacy was developed at Kentucky BioProcessing (KBP).

    "Using a fully automated production system that operates in accordance with good manufacturing practices (GMP), antibody is produced in a tobacco plant system.

    There is NO technical hurdle in mass production of the products.

    Reynolds Tobacco works in conjunction with Kentucky BioProcessing.
    Last edited by Bob; 8th August 2014 at 05:21.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Ebola patient now in Europe

    Miguel Pajares, 75, a Spanish missionary priest working at a hospital in the West African country, will be taken to Spain by a military jet has arrived by ambulance to a "special isolation ward".

    Is that like the CDC/Emory containment Facility or something like over in Sierra Leone/Liberia?

    What type of precautions, masks, air flow?

    Source

    Miguel Pajares is currently listed in STABLE condition.



    Father Pajares was escorted from the air force base to the hospital by a lengthy convoy medical and police vehicles.

    On the flight from Liberia, Father Pajares was accompanied by a nun from Equatorial Guinea, who Spanish press reports said holds Spanish citizenship. She had tested negative for Ebola, but was also admitted to an isolation unit in the hospital, as a precautionary measure. Spanish health officials described her as being in "a generally good condition."

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Auburn University Treatment in the offing

    Researchers in Auburn University have said they have a new method which will work with at least 12 different but somewhat related virus types.


    This is the KEY they say..

    "The Ebola virus is able to turn off the body’s natural immune response. But researchers at Auburn University believe they’ve developed an “on-switch.” "

    An ON-SWITCH which tells the body, GO AFTER THE INVADER, NOW.. wake up !

    WY3161 is a relatively small molecule. The compound appears to reverse the immune-blocking effects of certain viruses, including Ebola, when tested on cells from green monkeys.

    Auburn researchers plan to publish details of their findings later this month in the journal Bioorganic & Medicinal Chemistry.

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Emory Isolation unit reveals how it is constructed and why

    Source



    "Emory University Hospital has a special isolation unit, called a Serious Communicable Disease Unit, that was set up in collaboration with the CDC to house CDC scientists and others who have traveled abroad and become exposed to infectious diseases.

    "This unit has unique equipment and infrastructure that provides an extraordinarily high level of clinical isolation with very different capabilities than are normally provided to isolate patients in other hospitals. It is one of only four such facilities in the country.

    "This illustration above shows an anteroom for physicians and nurses, two patient rooms and attached patient support rooms and a staff dressing room. Glass windows in patient rooms allow the patient and family to see one another."

    The above was published by Emory Wednesday, August 6, 2014 to "explain" the facility to the public.

    Q: Could other Ebola patients come to Emory University Hospital also?

    At this time there are no plans for additional patients (Emory planing policy statement.)

    Emory has released a short 4m.45s minute video on Ebola to help educate the public:


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    Smile Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Thankyou Bob,
    A psycho-social aspect of Ebola infection prevention might prove to be public health authorities recommending differing approaches to greeting people.
    Welcome to,

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    Default Re: Haemorrhagic fever / Ebola outbreaks have been reported - accident, natural or bio-weapon?

    Third Drug works for Ebola Zaire - but we never heard about it - Pentagon keeping things under military "need to know", NDA's (weapons projects, and countermeasures)..

    We've heard that the licensing of ZMapp restrictions won't let it become available to Africa.. Financial greed more so than compassionate desires to help mankind..

    BUT there is an Angel out there.. however that Angel may have a Devil to deal with - see below..

    Sarepta’s drug remains available

    Sarepta’s president and CEO, Chris Garabedian, told Barron’s earlier this week that the company had a drug that could be deployed and shipped if a request was made of the company and all permits and authorizations were cleared.


    Garabedian told me on Tuesday that company does indeed have clinical trial-quality drug on hand. The Marburg program that has continued “uses the same backbone chemistry,” so the safety studies that are continuing with that drug at higher human doses could be applied to AVI-7537.

    “We’re here to raise awareness that we do have a technology that might be helpful, and that we do have drug substance on hand if we received a request from a government agency,” said Garabedian. “We, of course, would have to get the appropriate waivers and approvals from the Department of Defense who supported the development of this compound as well as the FDA in terms of an emergency use authorization.”

    The U.S. Army Medical Research Institute for Infectious Diseases (USAMRIID) is a co-assignee on the two patents, not expiring until 2025, that cover Sarepta’s Ebolavirus drugs.

    Beyond the fact that the U.S. government has already made a significant investment in Sarepta’s drug, the company already holds an open IND for human clinical trials.

    “We’re just highlighting that we have drug substance available and we can go to convert that into finished product in vials. Assuming all approvals are there from the various agencies, we could have this ready in a week for compounding in a pharmacy for dosing into a patient,” said Garabedian.

    Should any agency or institution wish to make such a request, this wouldn’t be the first time Sarepta had made a drug available on an emergency basis. In fact, the genesis of Sarepta’s Ebola program was the government’s acute need for a drug.

    (Source)

    Phase 1 safety trials with the drug alone and together another Ebola-directed PMOplus molecule (AVI-7539, with the combination called AVI-6002).

    The work, done with the support of the Department of Defense, was part of a project put on hold in 2012 during the fiscal cliff fiasco.

    The Ebola drug proved to have an excellent safety profile in a single dose escalation study and a two-week, daily dosing regimen. So the discontinuation was more likely due to economics than medical concerns. In support of that speculation, the DoD continued to support Sarepta’s Marburg virus program.

    CONTACT US @ Sarepta

    PATIENTS, FAMILIES, AND HEALTHCARE PROVIDERS
    skipahead@sarepta.com
    (Toll-Free) 855.DMD.SKIP (855.363.7547)

    GENERAL INQUIRIES
    info@sarepta.com
    617.274.4000

    Sarepta Therapeutics Headquarters
    215 First Street
    Cambridge, MA 02142

    Sarepta Therapeutics Corvallis
    4575 SW Research Way
    Suite 200
    Corvallis, OR 97333

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