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    Avalon Member Carmody's Avatar
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    Default Neural regeneration is here (with a side order of potential enhancement)

    Stem cell therapy heals injured mouse brain

    August 22, 2016



    Stem cell therapy heals injured mouse brain
    Giving a compound called 3K3A-APC to mice with stroke-induced brain damage dramatically increased the production of new neurons (labeled in red) from neural stem cells implanted next to the injured area. Credit: Berislav Zlokovic, M.D., Ph.D., University of Southern California


    Permanent brain damage from a stroke may be reversible thanks to a developing therapeutic technique, a USC-led study has found.

    The novel approach combines transplanted human stem cells with a special protein that the U.S. Food and Drug Administration already approved for clinical studies in new stroke patients.

    "This USC-led animal study could pave the way for a potential breakthrough in how we treat people who have experienced a stroke," said Jim Koenig, a program director at the National Institute of Neurological Disorders and Stroke, which funded the research. "If the therapy works in humans, it could markedly accelerate the recovery of these patients."

    Berislav Zlokovic, senior author of the Aug. 22 Nature Medicine study, and his colleagues identified a protein that spurs neural stem cells to become functional neurons: 3K3A-APC, a variant of the human protein "activated protein C."

    The created compound is being tested as a neuroprotectant. Researchers in a National Institutes of Health-funded Phase II clinical trial administer 3K3A-APC to patients who have very recently (within a few hours) suffered from an ischemic stroke, when a clot blocks blood from reaching the brain. About 87 percent of all strokes are ischemic, according to the Centers for Disease Control and Prevention.

    However, Zlokovic, director of the Zilkha Neurogenetic Institute at the Keck School of Medicine of USC, said he and his colleagues are the first to use 3K3A-APC to produce neurons from human stem cells grafted into the stroke-damaged mouse brain.

    "We showed that 3K3A-APC helps the grafted stem cells convert into neurons and make structural and functional connections with the host's nervous system," said Zlokovic, a scientific founder of ZZ Biotech, a company devoted to developing therapeutics using variants of activated protein C. "No one in the stroke field has ever shown this, so I believe this is going to be the gold standard for future studies."

    Although other researchers have experimented with grafting stem cells into injured brain areas, they have met with limited success—partially because transplanted stem cells diminish with time. The therapeutic compound stops that from happening.

    Every year more than 795,000 people in the United States have a stroke, according to the CDC. These debilitating seizures reduce mobility in more than half of stroke survivors age 65 and older.

    More than 70 percent of stroke survivors live with substantial neurological symptoms such as muscle weakness or paralysis, according to Yaoming Wang, co-lead author of the study and a senior research associate at the Zilkha Neurogenetic Institute at the Keck School.

    "The need for an efficacious, practical and late treatment of stroke remains unmet," Wang said. "Regenerative medicine with stem cells holds great promise for the treatment of stroke."

    How combination therapy works

    A week—the equivalent of several months in humans—after scientists induced a stroke in mice, the researchers placed human neural stem cells next to damaged brain tissue. Then they administered the immunosuppressant cyclosporine and four doses of 3K3A-APC or a placebo solution over a span of seven days.

    The transplanted stem cells matured into neurons and other brain cells. Mice treated with the special compound had 16 times more human stem cell-derived neurons than those who were treated with the placebo.

    "Functional deficit after five weeks of stroke were minimized, and the mice were almost back to normal in terms of motor and sensorimotor functions," Zlokovic said. "Synapses formed between transplanted cells and host cells, so there is functional activation and cooperation of transplanted cells in the host circuitry."

    To test whether the injected stem cells caused the observed motor and sensorimotor improvements, USC researchers used an assassin toxin to exterminate neurons that developed from human stem cells. They found that these mice lost improvements in motor or sensory tests, suggesting the neurons that grew from implanted stem cells were necessary for recovery from stroke-induced disability.

    The motor and sensory tests

    Researchers tested motor functions by having mice walk forward on a rotating rod without falling off. They tested sensory and motor function by placing tape on the mouse's forepaw and observed how long it took the mice to remove the adhesive.

    Rodents given human stem cells and treated with 3K3A-APC performed much better on these performance tests, said Zhen Zhao, co-lead author and an assistant professor of research physiology and biophysics at the Zilkha Neurogenetic Institute.

    Functional integration

    To test the brain's circuitry after the stroke, researchers labeled stem cells with an indicator of neuronal activity and then stimulated the paws of the mice with a mechanical vibration. They noted the injured area in 3K3A-APC-treated mice was activated much more than in mice treated with the placebo. Moreover, the response time was much closer to that of uninjured mice.

    These results suggest that neurons which grew from the stem cells are functionally integrated into the host's brain circuitry.

    The future of stem cell therapy

    In June, Stanford University researchers drilled a hole into the skulls of people whose motor and sensory abilities had been compromised because of stroke. Then they injected stem cells harvested from the bone marrow of adult donors. Although the study involved only 18 patients, researchers noted meaningful recovery, such as the ability to walk again. Stanford researchers said the stem cells seemed to trigger a biochemical process that enhanced the brain's ability to regenerate neurons. The transplanted stem cells themselves did not become neurons.

    In contrast, researchers in the USC-led study were able to stimulate transplanted stem cells to becoming neurons in a mouse study.

    Zlokovic and his team now hope to pursue a new Phase II clinical trial to test whether their combination therapy that stimulated the growth of neurons in mice can be replicated in human stroke patients. If the trial succeeds, they plan to extend the neural stem cell grafts and 3K3A-APC treatment to other neurological conditions, such as spinal cord injuries.
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    United States Avalon Member Mike's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    Very interesting stuff.

    Ive just begun taking a supplement called "imortalium". It's supposed to encourage stem cell production qnd telomere integrity. For the price of a small, 3rd world country of course...

    It works. Ive been on it for a few weeks, and its changed my life.

    Stem cells: as howard hughes would say (as leo dicaprio) "it's the way of the future...the way of the future...the way of the future.."
    Last edited by Mike; 22nd August 2016 at 19:15.
    [I]My head says 'who cares?', but my heart whispers 'you do, stupid...'"[/I]

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    Avalon Member Carmody's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    PTSD is a possible treatment, here.

    Some forms of PTSD are related to shell shock, or concussive based neural/brain damage. Micro capillaries are blown out in the brain, from the pressure wave of the given proximate explosive blast.

    To fix the broken pathways from the IED having blown out the bottom of the hummer when the person was in Iraq, for example. To regain a life.

    Now that medical technology is so good, a lot of soldiers who might have died, are now saved..... but they suffer brain damage, and are lost in the veteran's medical system.

    Same for football players, or boxers, possibly. This may offer avenue to end the plague of brain scarring.
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    Avalon Member Flash's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    Yes, because of shell shock and broken capilaries in the brain, someone I know who works with hyperbaric chambers had designed a protocol to get oxygen to the brain of shell shock soldiers to enhance repair of these soldier's brain capacities. He presented it to the US army with all the studies confirming what he was talking about and they never used it, nor try to implement anything having to do with brain enhancement. This could have saved thousands from hell.

    So I bet this would be the same, used for the elite but not for the layman.

    Quote Posted by Carmody (here)
    PTSD is a possible treatment, here.

    Some forms of PTSD are related to shell shock, or concussive based neural/brain damage. Micro capillaries are blown out in the brain, from the pressure wave of the given proximate explosive blast.

    To fix the broken pathways from the IED having blown out the bottom of the hummer when the person was in Iraq, for example. To regain a life.

    Now that medical technology is so good, a lot of soldiers who might have died, are now saved..... but they suffer brain damage, and are lost in the veteran's medical system.

    Same for football players, or boxers, possibly. This may offer avenue to end the plague of brain scarring.
    How to let the desire of your mind become the desire of your heart - Gurdjieff

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    United States Avalon Member onawah's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    How has it changed your life, Mike?
    Quote Posted by Mike (here)
    Very interesting stuff.

    Ive just begun taking a supplement called "imortalium". It's supposed to encourage stem cell production qnd telomere integrity. For the price of a small, 3rd world country of course...

    It works. Ive been on it for a few weeks, and its changed my life.

    Stem cells: as howard hughes would say (as leo dicaprio) "it's the way of the future...the way of the future...the way of the future.."
    Each breath a gift...
    _____________

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    Scotland Avalon Member Daozen's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    I was thinking about the other longevity article you posted the other day, Carmody. This and your other thread are among the most valuable on Avalon. No idea why they don't get more attention, as we are all terminal cases of progeria. Those kids that aged so rapidly they died at 14 were a gift to science. Maybe they were incarnated angels. Some say they have an accelerated form of a disease we ALL have.

    https://en.wikipedia.org/wiki/Progeria

    On Avalon, we know that you can cure most cases of cancer for less than a dollar a day. Hemp oil, iodine, Methylsulfurmethane, B17, bicarbonate therapy... It's all dirt cheap. We know pharmaceutical companies charge hundreds of thousands for treatments that are far worse than nature. I bet the same thing is going on in longevity. Canny life-extension companies are making a lot of money selling products that can be bought much cheaper. There's also a link between cancer and death itself. Even heart disease may be just 'cancer of the arteries'. Fungus, telomere damage, mold and nanocalicum buildup are all related to aging. How? I don't know yet. I would look for 'natural stem cell regeneration', if such a thing exists.

    Mike, if you have time, can you tell us in more detail how you feel on Imortalium? I bet that company are manufacturing those pills for less than 5 USD, and making a healthy markup of more than 2000% per pill. I bet with 2-6 months of research, anyone could find the ingredients and buy them direct.

    They say the 3 major causes of aging are inflamation, inflamation, and inflamation. Cell regeneration starts when you stimulate autophagy with dry fasting. I've been eating only one meal a day for the last 5 weeks. I feel 10, if not 20 years younger. Do I look younger? A little, but not so much. I'm also eating a lot of high boron foods, like walnuts and raisins. All my late thirties aches and pains have just disappeared.
    http://tinyurl.com/oke7jvm //// "the love that you withhold, is the the pain that you carry... (lifetime after lifetime)..." - Alex Collier.

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    United States Avalon Member Mike's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    For Nat and Daozen,

    Imortalium is one of the many supplements being sold by Youngevity, a company headed by a Dr Joel Wallach. He's had appearances on 'Coast to Coast' and 'Ground Zero'. I won't list all his credentials here - they are easily googleable. So are the ingredients (sorry Daozen, not sure how to provide links from my phone), which, at first glance anyway, don't seem all that impressive or exotic....but work with a wonderful synergy. I spose I could take all the ingredients separately, but I doubt i'd save any money (despite the high price $58) and it would be quite inconvenient.

    I listened to Dr Wallach over several interviews, and was impressed by his boldness and matter of factness. His theories are quite simple and easy to understand. And truthfully, I long ago lost interest in the how or why. Not really interested in the science either. I'm only interested in whether something works or not.

    My health issues are well documented here. Ive tried countless supplements. Some were very effective, but a great many were useless. So i'm quite jaded. I try new stuff with very little expectation..in fact, I usually expect it to fail. theres no placebo thing going on with me. So, with that in mind I ordered imortalium, because I had nothing to lose (money back guarantee if unsatisfied for any reason)

    All my improvements would be hard and tedious to explain if you didnt know the full history of my illness and its symptoms. In short, it(imortalium) has gotten me out of my bed and doing things I havent done in years (basketball, golf, working out etc). My condition affected my heart to such a degree that even talking and typing was difficult. Those issues are gone now...in fact, now I cant shut up. Sleeping was rare, because my breathing was compromised. I dont have that problem now. The effects of imortalium were swift and dramatic. They were miraculous.

    And no, I am not affiliated with the company in any way

    If you have any more specific questions, feel free to pm me and i'll try to answer them.
    Last edited by Mike; 24th August 2016 at 04:11.
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    Scotland Avalon Member Daozen's Avatar
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    Default Re: Neural regeneration is here (with a side order of potential enhancement)

    Thanks for typing that up, Mike. Actually, I never knew you were ill. Good to hear you are better. I hope you add Lugols or Detoxadine to your regimen. I don't sell either of them. Povidone, then Detoxadine, saved me from near death with mitral valve prolapse two years ago. I bought nearly every supplement out there too, mainly for chronic fatigue in my early twenties. Like you, I found most of of them didn't work. I just take Iodine, B-Vits, and some MSM nowadays. I also fast and eat high boron foods. That's all I do. I'm healthier than I ever was, and it costs close to zero.

    http://www.imortalium.com/

    I like Joel Wallach's approach of using simple ingredients in a powerful combination. As far as nutrition is concerned, we still don't even take care of the basics. Interestingly, I clicked on a random Joel Wallach video at a random time, and one of the first words out of his mouth was inflammation, which I had just written about. He seems healthy, happy and vivacious.

    https://youtu.be/YM4zFDjQuTY?t=480

    Honestly, 58USD isn't that much compared to Western medical care. When you said small African country, I was thinking more like 580USD. I guess 4 tablets at a time would cost more like 58USD per week, but non-chronic cases could take only 1 tablet per day, or even 1 every other day.

    I heard of cobalt blue, one of the ingredients. I am a little concerned about the 1mg of copper, as that is a controversial mineral that we don't understand yet, but your testimonial means something to me. Some say that copper helps avoid iron buildup, which is a major hidden cause of disease. They say that women live longer because their monthly cycle helps them get rid of excess iron.

    This essay is somewhat hysterical, one-sided and overblown, but I sense there are some truths within it:

    http://www.unveilingthem.com/Poisoni...Deficiency.htm

    Excess copper can supposedly be toxic, so it's an area that people need to be cautious about. Personally, I wouldn't want to take copper as a supplement, but I've been eating high copper foods recently, and I feel better than ever. But if it's working for you, it must be OK.

    Ingredients here, BTW:
    http://www.imortalium.com/supplement-facts.html

    http://www.imortalium.com/

    I know for a fact that there are people who live many hundreds of years on this Earth. They just keep quiet about it.

    *

    I would happily PM you, but maybe it's better to talk out loud so others can read. Thanks again, I'll forward that link to my parents ASAP.
    Last edited by Daozen; 24th August 2016 at 06:26.
    http://tinyurl.com/oke7jvm //// "the love that you withhold, is the the pain that you carry... (lifetime after lifetime)..." - Alex Collier.

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