Bob
30th October 2018, 16:41
It's not colloidal silver, doing the work for killing off dangerous amoeba infections in areas of the brain and eyes, where untreated leads to a horrible death and blindness...
It is silver though, in the form of nano-particle coatings attached to common anti-spasmotic anti-seizure drugs used to treat conditions such as seizures.
We have a thread referenced here: http://projectavalon.net/forum4/showthread.php?84025-Brain-eating-infection-is-back-again-in-Louisiana&p=982932&viewfull=1#post982932 which talks about a particular type of amoeba that can contaminate water systems.
The two types of amoebas are known as:
Naegleria fowleri - a brain eating amoeba
Acanthamoeba castellanii - can enter the eyes through dirty contact lenses
Here are excerpts from the article of October 24, 2018, from the American Chemical Society:
Most cases result from inhaling warm, dirty water in ponds, hot springs or un-chlorinated swimming pools.
Another species, Acanthamoeba castellanii, can cause blindness by entering the eyes through dirty contact lenses.
Common treatments include antimicrobial drugs, but they often cause severe side effects because of the high doses required for them to enter the brain.
Researchers Ayaz Anwar and colleagues wondered if three anti-seizure drugs—diazepam, phenobarbitone and phenytoin—could kill amoebae, alone or in combination with silver nanoparticles.
The drugs are already approved by the U.S. Food and Drug Administration and are known to cross the blood-brain barrier.
The researchers reasoned that they might be more effective when attached to silver nanoparticles (not colloidal silver), which can improve the delivery of some drugs and also have their own antimicrobial effects.
Technical:
How the nanoparticles were created - Nanoparticles were synthesized by sodium borohydride reduction of silver nitrate with drugs as capping agents. Drugs conjugated nanoconjugates were characterized by ultraviolet-visible (UV-vis), and Fourier transform infrared (FT-IR) spectroscopies, and atomic force microscopy (AFM).
article references:
https://phys.org/journals/acs-chemical-neuroscience/
https://phys.org/news/2018-10-brain-eating-amoebae-halted-silver-nanoparticles.html
Ayaz Anwar - Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor, Malaysia. - https://aac.asm.org/content/early/2018/06/26/AAC.00630-18 - in this article Anwar and colleagues used gold nanoparticles attached to Cinnamic acid to kill the Acanthamoeba castellanii type of amoeba. The gold-nanoparticle-cinnamic acid combination was also effective in killing MRSA bacteria - methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1.
It is silver though, in the form of nano-particle coatings attached to common anti-spasmotic anti-seizure drugs used to treat conditions such as seizures.
We have a thread referenced here: http://projectavalon.net/forum4/showthread.php?84025-Brain-eating-infection-is-back-again-in-Louisiana&p=982932&viewfull=1#post982932 which talks about a particular type of amoeba that can contaminate water systems.
The two types of amoebas are known as:
Naegleria fowleri - a brain eating amoeba
Acanthamoeba castellanii - can enter the eyes through dirty contact lenses
Here are excerpts from the article of October 24, 2018, from the American Chemical Society:
Most cases result from inhaling warm, dirty water in ponds, hot springs or un-chlorinated swimming pools.
Another species, Acanthamoeba castellanii, can cause blindness by entering the eyes through dirty contact lenses.
Common treatments include antimicrobial drugs, but they often cause severe side effects because of the high doses required for them to enter the brain.
Researchers Ayaz Anwar and colleagues wondered if three anti-seizure drugs—diazepam, phenobarbitone and phenytoin—could kill amoebae, alone or in combination with silver nanoparticles.
The drugs are already approved by the U.S. Food and Drug Administration and are known to cross the blood-brain barrier.
The researchers reasoned that they might be more effective when attached to silver nanoparticles (not colloidal silver), which can improve the delivery of some drugs and also have their own antimicrobial effects.
Technical:
How the nanoparticles were created - Nanoparticles were synthesized by sodium borohydride reduction of silver nitrate with drugs as capping agents. Drugs conjugated nanoconjugates were characterized by ultraviolet-visible (UV-vis), and Fourier transform infrared (FT-IR) spectroscopies, and atomic force microscopy (AFM).
article references:
https://phys.org/journals/acs-chemical-neuroscience/
https://phys.org/news/2018-10-brain-eating-amoebae-halted-silver-nanoparticles.html
Ayaz Anwar - Department of Biological Sciences, School of Science and Technology, Sunway University, Selangor, Malaysia. - https://aac.asm.org/content/early/2018/06/26/AAC.00630-18 - in this article Anwar and colleagues used gold nanoparticles attached to Cinnamic acid to kill the Acanthamoeba castellanii type of amoeba. The gold-nanoparticle-cinnamic acid combination was also effective in killing MRSA bacteria - methicillin-resistant Staphylococcus aureus, and neuropathogenic Escherichia coli K1.