Bob
12th January 2019, 01:16
We have seen Creatine supplementation talked about for muscle building.
There is potentially another use when there is depression, anxiety, confusion, "dyslexia", general weakness.. The list goes on.
Parkinsonism symptoms starting up could be due to a deficiency in brain levels of Creatine.
Brain disorders are generally treated with hard core drugs to mask or put the person into another state to thereby hide the condition at hand - quite possibly a deficiency.
Memory alteration mimicking Alzheimers or dementia, argumentativeness, often times leads to tugging at the heart-strings of care givers, or pushes the buttons of the medical establishment to "treat" symptoms with all the wrong and aggressive chemicals.
How it's been monitored
Much of the recent evidence on changes in brain creatine metabolism in humans has been provided by studies using magnetic resonance spectroscopy (MRS), a neuro-imaging tool that enables scientists to non-invasively measure major metabolites like creatine and phosphocreatine in various brain regions in vivo (in the body).
Stress increases the need for Creatine supplementation.
Changes in Creatine metabolism observed in schizophrenia, mood and anxiety disorders.
Could it be that simple?
Possibly.
People who are deficient in certain foods and not supplementing, or have various organ diseases (such as previously from damage from alcohol, cigarettes, viral hepatitis, or liver cancers), Creatine would be a constituent of a normal diet of protein-based foods, such as milk, meat, and nuts.
It is not considered an essential nutrient because the kidneys, liver, pancreas, and possibly brain cells are able to synthesize this compound endogenously from the amino acids arginine, glycine, and methionine. If one is deficient in arginine, glycine and methionine, one could indeed be invoking a Creatine deficiency.
Daily supplementation with Creatine monohydrate reliably produces measurable increases of Creatine and phosphocreatine in the brain in humans and animals after several weeks.
Cognitive or emotional deficits can be observed in numerous brain-related disorders. The expression, "Don't you understand me, can't you empathise with me, don't you feel what I am feeling? are often present before the condition becomes intractable.
Body building
Creatine is most commonly recognized as an ergogenic (intended to enhance physical performance, stamina, or recovery) aid used by athletes, body builders, and military personnel to enhance muscle mass and physical performance during brief intervals of extremely intense activities, which rapidly deplete muscle energy stores, such as bench press lifting, sprinting, or swimming.
Consider a type of chronic wasting of brain tissue, muscle tissue, and organs happens when Creatine is depleted from stress (muscles held in a state of tension)... Mitochondrial dysfunction may arise when phosphocreatine is repeatedly depleted. The mechanism of energy production for the cells is damaged.. (In another thread we talked about how Magnesium Bicarbonate could be extremely useful for kick starting mitochondrial functions of respiration).
Then possibly, Creatine and Magnesium Bicarbonate supplementation might be a great combination in helping with neuro-psychogenic issues, and body weakness in general.
When the body is stressed, the body will pull Creatine from whatever stores it can find. Have we ever noticed elderly becoming harder to communicate with? Have we seen what their diets are? Have they complained about weakness, not wanting to move about? Are we seeing deficiencies in other words?
The concept of growing old, experiencing the factors that appear may be more easily corrected by proper supplementation, looking at what was depleted due to particular lifestyles.
Treatment thru supplementation
In humans and in animals, research has consistently shown that administration of creatine over a prolonged period of time results in measurable increases of creatine concentrations in brain and muscle tissue, which is most pronounced after 4 weeks.
Therapeutic activity - In patient populations, the schedule of Creatine administration varies from clinical study to clinical study because guidelines have not been definitively established.
However, to increase brain Creatine levels in human populations, it has been recommended that investigators implement an initial loading phase (ranging from 15 to 20 g/d Creatine for approximately 3–7 days) to ensure tissue saturation, followed by a maintenance phase of ~5–10 grams for at least 2–3 months.
If there is going to be a marked improvement, that is what was being tested.
While Creatine is rapidly absorbed, different dosage forms (e.g. solutions, powders, capsules) can influence the bioavailability of Creatine.
Creatine supplementation is generally considered safe and well-tolerated by humans and animals (Rodriguez et al., 2009).
For instance, no significant adverse effects have been reported in studies of patients with inborn error of Creatine synthesis given up to 0.8 g/kg daily for two years (reviewed in Braissant and Henry, 2008).
Likewise, no major health issues were reported in a study of 9 healthy athletes administered 1–20 g/day from 1–4 times/day for up to five years.
Reported large dose side effects - mild to moderate (weight gain, gastrointestinal distress, altered insulin production, inhibition of endogenous creatine synthesis, renal dysfunction, or dehydration in study participants).
If one is being monitored for Kidney function, taking Creatine supplementation can confuse kidney creatine level tests. "Creatine supplementation can confound renal analyses because serum Creatinine is the most widely used marker of renal function (Gualano et al., 2008). Creatine supplementation increases levels of Creatinine, which can be falsely interpreted as an indication of renal dysfunction. One must tell the ones doing testing that one is taking Creatine supplementation if being monitored for creatinine for kidney function in other words.
The majority of studies conclude that Creatine supplementation is generally not harmful to the kidneys when used as directed (Dalbo et al., 2008).
Keeping up on fluid intake - physicians typically advise drinking extra water and avoiding caffeine when taking Creatine supplements.
Benefits for older adults: In older adults (~76 years of age), creatine buffered age-related cognitive decline, with improvement in verbal and spatial short-term memory and long-term memory after one week of daily supplementation (McMorris et al., 2007b).
Studies of vegetarian and vegan subjects may have shown greater benefit in cognitive processing post-supplementation because they presumably have lower brain Creatine levels due to dietary restrictions.
Cognitive and behavioral improvement is observed in Creatine deficiency patients.
Schizophrenia
Schizophrenia is a behaviorally and biochemically heterogeneous disorder characterized by psychotic episodes, which are periods of time in which the individual experiences significant disturbances in thought and/or loses contact with reality.
Symptoms manifestations include delusions, hallucinations, disorganized thought or speech, catatonic behavior, and/or negative symptoms. (One can in such episodes say they are being attacked by aliens, beams from "out there", or from 'everything' about one is specifically attacking them due to some worldwide conspiracy)..
Verifying the mechanism in those experiencing schizophrenic episodes, impairments in metabolic function, neuronal density and cellular integrity in the frontal and temporal lobes of the brain, basal ganglia, and hippocampus have been observed in those schizophrenic patients.
Increasing evidence supports the use of Creatine monohydrate for preventing or treating depression.
Could it be that simple? Creatine supplementation and Magnesium Bicarbonate?
reference -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340488/
Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O’Reilly SL, Nicholson GC, Kotowicz MA, Berk M. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry. 2010;167:305–311. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/20048020)]
Jensen JE. Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla. The British Journal of Psychiatry. 2004;184:409–415. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/15123504)]
Allen PJ, D’Anci KE, Kanarek RB. Creatine, brain functioning, and behavior. In: Kanarek RB, Lieberman HR, editors. Diet, Brain and Behavior: Practical Implications. Taylor and Francis; New York: 2011. pp. 215–236.
Amital D, Vishne T, Roitman S, Kotler M, Levine J. Open study of creatine monohydrate in treatment-resistant posttraumatic stress disorder. J Clin Psychiatry. 2006;67:836–837. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/16841637)]
There is potentially another use when there is depression, anxiety, confusion, "dyslexia", general weakness.. The list goes on.
Parkinsonism symptoms starting up could be due to a deficiency in brain levels of Creatine.
Brain disorders are generally treated with hard core drugs to mask or put the person into another state to thereby hide the condition at hand - quite possibly a deficiency.
Memory alteration mimicking Alzheimers or dementia, argumentativeness, often times leads to tugging at the heart-strings of care givers, or pushes the buttons of the medical establishment to "treat" symptoms with all the wrong and aggressive chemicals.
How it's been monitored
Much of the recent evidence on changes in brain creatine metabolism in humans has been provided by studies using magnetic resonance spectroscopy (MRS), a neuro-imaging tool that enables scientists to non-invasively measure major metabolites like creatine and phosphocreatine in various brain regions in vivo (in the body).
Stress increases the need for Creatine supplementation.
Changes in Creatine metabolism observed in schizophrenia, mood and anxiety disorders.
Could it be that simple?
Possibly.
People who are deficient in certain foods and not supplementing, or have various organ diseases (such as previously from damage from alcohol, cigarettes, viral hepatitis, or liver cancers), Creatine would be a constituent of a normal diet of protein-based foods, such as milk, meat, and nuts.
It is not considered an essential nutrient because the kidneys, liver, pancreas, and possibly brain cells are able to synthesize this compound endogenously from the amino acids arginine, glycine, and methionine. If one is deficient in arginine, glycine and methionine, one could indeed be invoking a Creatine deficiency.
Daily supplementation with Creatine monohydrate reliably produces measurable increases of Creatine and phosphocreatine in the brain in humans and animals after several weeks.
Cognitive or emotional deficits can be observed in numerous brain-related disorders. The expression, "Don't you understand me, can't you empathise with me, don't you feel what I am feeling? are often present before the condition becomes intractable.
Body building
Creatine is most commonly recognized as an ergogenic (intended to enhance physical performance, stamina, or recovery) aid used by athletes, body builders, and military personnel to enhance muscle mass and physical performance during brief intervals of extremely intense activities, which rapidly deplete muscle energy stores, such as bench press lifting, sprinting, or swimming.
Consider a type of chronic wasting of brain tissue, muscle tissue, and organs happens when Creatine is depleted from stress (muscles held in a state of tension)... Mitochondrial dysfunction may arise when phosphocreatine is repeatedly depleted. The mechanism of energy production for the cells is damaged.. (In another thread we talked about how Magnesium Bicarbonate could be extremely useful for kick starting mitochondrial functions of respiration).
Then possibly, Creatine and Magnesium Bicarbonate supplementation might be a great combination in helping with neuro-psychogenic issues, and body weakness in general.
When the body is stressed, the body will pull Creatine from whatever stores it can find. Have we ever noticed elderly becoming harder to communicate with? Have we seen what their diets are? Have they complained about weakness, not wanting to move about? Are we seeing deficiencies in other words?
The concept of growing old, experiencing the factors that appear may be more easily corrected by proper supplementation, looking at what was depleted due to particular lifestyles.
Treatment thru supplementation
In humans and in animals, research has consistently shown that administration of creatine over a prolonged period of time results in measurable increases of creatine concentrations in brain and muscle tissue, which is most pronounced after 4 weeks.
Therapeutic activity - In patient populations, the schedule of Creatine administration varies from clinical study to clinical study because guidelines have not been definitively established.
However, to increase brain Creatine levels in human populations, it has been recommended that investigators implement an initial loading phase (ranging from 15 to 20 g/d Creatine for approximately 3–7 days) to ensure tissue saturation, followed by a maintenance phase of ~5–10 grams for at least 2–3 months.
If there is going to be a marked improvement, that is what was being tested.
While Creatine is rapidly absorbed, different dosage forms (e.g. solutions, powders, capsules) can influence the bioavailability of Creatine.
Creatine supplementation is generally considered safe and well-tolerated by humans and animals (Rodriguez et al., 2009).
For instance, no significant adverse effects have been reported in studies of patients with inborn error of Creatine synthesis given up to 0.8 g/kg daily for two years (reviewed in Braissant and Henry, 2008).
Likewise, no major health issues were reported in a study of 9 healthy athletes administered 1–20 g/day from 1–4 times/day for up to five years.
Reported large dose side effects - mild to moderate (weight gain, gastrointestinal distress, altered insulin production, inhibition of endogenous creatine synthesis, renal dysfunction, or dehydration in study participants).
If one is being monitored for Kidney function, taking Creatine supplementation can confuse kidney creatine level tests. "Creatine supplementation can confound renal analyses because serum Creatinine is the most widely used marker of renal function (Gualano et al., 2008). Creatine supplementation increases levels of Creatinine, which can be falsely interpreted as an indication of renal dysfunction. One must tell the ones doing testing that one is taking Creatine supplementation if being monitored for creatinine for kidney function in other words.
The majority of studies conclude that Creatine supplementation is generally not harmful to the kidneys when used as directed (Dalbo et al., 2008).
Keeping up on fluid intake - physicians typically advise drinking extra water and avoiding caffeine when taking Creatine supplements.
Benefits for older adults: In older adults (~76 years of age), creatine buffered age-related cognitive decline, with improvement in verbal and spatial short-term memory and long-term memory after one week of daily supplementation (McMorris et al., 2007b).
Studies of vegetarian and vegan subjects may have shown greater benefit in cognitive processing post-supplementation because they presumably have lower brain Creatine levels due to dietary restrictions.
Cognitive and behavioral improvement is observed in Creatine deficiency patients.
Schizophrenia
Schizophrenia is a behaviorally and biochemically heterogeneous disorder characterized by psychotic episodes, which are periods of time in which the individual experiences significant disturbances in thought and/or loses contact with reality.
Symptoms manifestations include delusions, hallucinations, disorganized thought or speech, catatonic behavior, and/or negative symptoms. (One can in such episodes say they are being attacked by aliens, beams from "out there", or from 'everything' about one is specifically attacking them due to some worldwide conspiracy)..
Verifying the mechanism in those experiencing schizophrenic episodes, impairments in metabolic function, neuronal density and cellular integrity in the frontal and temporal lobes of the brain, basal ganglia, and hippocampus have been observed in those schizophrenic patients.
Increasing evidence supports the use of Creatine monohydrate for preventing or treating depression.
Could it be that simple? Creatine supplementation and Magnesium Bicarbonate?
reference -
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340488/
Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O’Reilly SL, Nicholson GC, Kotowicz MA, Berk M. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry. 2010;167:305–311. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/20048020)]
Jensen JE. Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla. The British Journal of Psychiatry. 2004;184:409–415. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/15123504)]
Allen PJ, D’Anci KE, Kanarek RB. Creatine, brain functioning, and behavior. In: Kanarek RB, Lieberman HR, editors. Diet, Brain and Behavior: Practical Implications. Taylor and Francis; New York: 2011. pp. 215–236.
Amital D, Vishne T, Roitman S, Kotler M, Levine J. Open study of creatine monohydrate in treatment-resistant posttraumatic stress disorder. J Clin Psychiatry. 2006;67:836–837. [PubMed (https://www.ncbi.nlm.nih.gov/pubmed/16841637)]