Extending the Human Lifespan Beyond 100 Years

[ExomatrixTV]

David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast:

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David Sinclair (https://en.wikipedia.org/wiki/David_A._Sinclair) is a geneticist at Harvard and author of Lifespan.

David Andrew Sinclair AO (born June 26, 1969) is an Australian biologist who is a professor of genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is known for his research on aging and has received numerous awards for his research, including the Australian Medical Research Medal and the Frontiers in Aging and Regeneration Award. In 2014, Sinclair was included in Time 100 as one of the hundred most influential people in the world, and in 2018 he was included in Time Magazine's 50 Most Influential People in Health Care. Sinclair was appointed Officer of the Order of Australia (AO) for "distinguished service to medical research into the biology of ageing and lifespan extension, as a geneticist and academic, to biosecurity initiatives, and as an advocate for the study of science".

Sinclair has appeared in various news outlets. Besides Time Magazine, he has appeared in The New York Times, The Charlie Rose Show, 60 Minutes, Boston Magazine, The Washington Post, The Economist, TED and The Joe Rogan Experience.


Lifespan: Why We Age – and Why We Don’t Have To ... audio-book (https://piratebayproxy.live/torrent/34647171/Lifespan__Why_We_Age__ndash__and_Why_We_Don_rsquo_t_Have_To)

[RunningDeer]

Thanks, John. http://paula.avalonlibrary.net/smilies/hat-baseball.gif



OUTLINE:
0:00 - Introduction
1:34 - Staying young at heart
5:30 - Bringing people back to life
11:05 - Wearables and tracking health data
20:18 - How to solve aging
30:22 - Why do we age?
35:50 - Genetic reset switch that reverses aging
38:20 - AI in biology
40:52 - Health data
48:58 - Fasting
56:29 - Diet
1:04:40 - Exercise
1:10:01 - Sleep
1:18:29 - Data
1:24:00 - Extending lifespan
1:26:42 - Immortality
1:32:28 - Denial of death
1:35:45 - Meaning of life without death



David Sinclair: Extending the Human Lifespan Beyond 100 Years | Lex Fridman Podcast:

jhKZIq3SlYE


David Sinclair (https://en.wikipedia.org/wiki/David_A._Sinclair) is a geneticist at Harvard and author of Lifespan.

David Andrew Sinclair AO (born June 26, 1969) is an Australian biologist who is a professor of genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is known for his research on aging and has received numerous awards for his research, including the Australian Medical Research Medal and the Frontiers in Aging and Regeneration Award. In 2014, Sinclair was included in Time 100 as one of the hundred most influential people in the world, and in 2018 he was included in Time Magazine's 50 Most Influential People in Health Care. Sinclair was appointed Officer of the Order of Australia (AO) for "distinguished service to medical research into the biology of ageing and lifespan extension, as a geneticist and academic, to biosecurity initiatives, and as an advocate for the study of science".

Sinclair has appeared in various news outlets. Besides Time Magazine, he has appeared in The New York Times, The Charlie Rose Show, 60 Minutes, Boston Magazine, The Washington Post, The Economist, TED and The Joe Rogan Experience.


Lifespan: Why We Age – and Why We Don’t Have To ... audio-book (https://piratebayproxy.live/torrent/34647171/Lifespan__Why_We_Age__ndash__and_Why_We_Don_rsquo_t_Have_To)

[ExomatrixTV]

How to Slow Aging (and even reverse it):

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[RunningDeer]

Geneticist David Sinclair on the Latest Anti-Aging Studies | Joe Rogan (12:34 min)

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[RunningDeer]

How to Slow Aging (and even reverse it):


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Scientists like Prof Sinclair have evidence of speeding up, slowing, and even reversing aging.

What causes aging? According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes. Epigenetics allow different cell types to perform their specific functions - they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc. When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

To counter this decline, we can activate the body's own defenses against aging by stressing the body. Eat less, eat less protein, engage in intense exercise, experience uncomfortable cold. When the body senses existential threats it triggers longevity genes, which attempt to maintain the body to ensure its survival until good times return. This may be the evolutionary legacy of early bacteria, which established these two modes of living (repair and protect vs grow and reproduce). Scientists are uncovering ways to mimic stresses on the body without the discomfort of fasting. Molecules like NMN also trigger sirtuins to monitor and repair the epigenome. This may slow aging.

Reversing aging requires an epigenetic reset, which may be possible using Yamanaka factors. These four factors can revert an adult cell into a pluripotent stem cell. Prof. Sinclair used three of the four factors to reverse aging in the retinal cells of old mice. He found they could see again after the treatment.

Special thanks to:
Professor David Sinclair, check out his book "Lifespan: Why We Age & Why We Don't Have To"
Assistant Professor David Gold

[palehorse]

Is it related to extropianism or transhumanism?

Anyway I will listen tonight. Thanks.

[ExomatrixTV]

2013: Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336960/)

The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.




2017: Epigenetic Resetting (https://journals.biologists.com/dev/article/144/15/2748/48060/Epigenetic-resetting-of-human-pluripotency) of Human Pluripotency



2019: Discovery of genes that reset epigenetic age (Horvath clock) | David Sinclair

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2021: Reprogramming Old Cells Young Again:

How researchers are hitting the reset switch on aged cells (https://www.lifespan.io/news/oskm/)



I wonder how much of all life-extension "discoveries" are not really new and they know it will eventually go mainstream ... before it does on a massive scale, they want to Depopulate (https://projectavalon.net/forum4/showthread.php?113012-The-Depopulation-Plan) the Earth first ... and only "the (obedient) chosen ones" are to live in their New Orwellian Technocratic (http://technocracy.news) Utopia as described in the Georgia-Guide-Stones (https://en.wikipedia.org/wiki/Georgia_Guidestones).

cheers,
John

[Bubu]

I have little interest in extending lifespan most of my interest is in having a happy life. Thankfully it seems to extend lifespan more than any of the ways mentioned here. We all know that being happy add years. This is on another level though and is not covered in this study. Someone someday will explain why being happy extends lifespan.

[Violet3]

I don't see how this guy's approach would work outside of a controlled lab setting within a notorious elite university with no doubt very pristine experimental setting. Outside that setting the environment is full of whatever is in the chemtrails, the fluoride and other crap in the water supplies and increasingly toxic oceans, the herbicides and GMO foods and plastics in everything, not to mention nanoparticles and now new 'vaccines'.