D-Ribose for Energy Production

[Natalia]

D-Ribose, a sugar that can help with energy production in the body and certain health conditions.

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Webmd page about D-Ribose and it's uses, sides effects, dosage, and scientific evidence:
http://www.webmd.com/vitamins-supplements/ingredientmono-827-ribose.aspx?activeingredientid=827&activeingredientname=ribose

A study on the effects of D-Ribose on clinical symptoms in patients with chronic fatigue syndrome and fibromyalgia:

J Altern Complement Med. 2006 Nov;12(9):857-62.

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.
Teitelbaum JE1, Johnson C, St Cyr J.

Abstract

OBJECTIVES:

Fibromyalgia (FMS) and chronic fatigue syndrome (CFS) are debilitating syndromes that are often associated with impaired cellular energy metabolism. As D-ribose has been shown to increase cellular energy synthesis in heart and skeletal muscle, this open-label uncontrolled pilot study was done to evaluate if D-ribose could improve symptoms in fibromyalgia and/or chronic fatigue syndrome patients.

DESIGN:

Forty-one (41) patients with a diagnosis of FMS and/or CFS were given D-ribose, a naturally occurring pentose carbohydrate, at a dose of 5 g t.i.d. for a total of 280 g. All patients completed questionnaires containing discrete visual analog scales and a global assessment pre- and post-D-ribose administration.

RESULTS:

D-ribose, which was well-tolerated, resulted in a significant improvement in all five visual analog scale (VAS) categories: energy; sleep; mental clarity; pain intensity; and well-being, as well as an improvement in patients' global assessment. Approximately 66% of patients experienced significant improvement while on D-ribose, with an average increase in energy on the VAS of 45% and an average improvement in overall well-being of 30% (p < 0.0001).

CONCLUSIONS:

D-ribose significantly reduced clinical symptoms in patients suffering from fibromyalgia and chronic fatigue syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/17109576

[Daozen]

I heard good things about this for heart disease too. I couldn't see any natural sources listed there...

http://www.ehow.com/list_5779478_foods-ribose.html

https://www.healthtap.com/topics/what-are-food-sources-of-d-ribose

[Olaf]

On a basis of about 1900 people with mitochondrial weakness that he has treated Dr. Bodo Kuklinski from Germany makes the following statements:

the most common reasons for low ATP production are (in this order)
- nitrosative stress (NO)
- lack of magnesium and/or potassium
- lack of vitamin B12 and/or biotin and/or folat (each of them needs the other two)
- lack of vitamin B1
- lack of vitamin B3
- lack of vitamin B2
- lack of vitamin B5
- lack of alpha lipon acid
...
- lack of ribose or other substances

The idea behind that is, that the production of ATP is a recycling process. In this citrat acid cycle all of the helper substances are needed that I have listed in the first part of the list. As a result of nitrosative stress often one ore more of these substances are consumed by chemical reactions so that one get a lack of those (mostly B vitamins and K, Mg). Thats why the first step of treatment should be correcting such deficits.
When the recycling is working, ATP production can still still be low. This is where ribose comes in. It is a source material for ADP production. So it can help to produce new ADP which then can enter the citrat cycle of ATP recycling.
Dr. Kuklinski states, that indeed there are few people who really benefit from ribose, when the citrat cycle is working.
Normally repairing the citrat cycle should be the first step.

You should remember that daily ATP production is about 60...80 kg. (!) People with insufficient mitochondria produce only 10...20 kg a day, which can be measured in red blood cells. Such a deficit cannot be compensated by only taking large amounts of ribose.
But it can be an important co-factor.
As Dr. Kuklinski sais: "One should just try it."

[1] Dr. Bodo Kuklinski: Das HWS Syndrom; 2006
[2] trainings with Dr. Kuklinski 2012, 2013, 2014

[Daozen]

Very interesting Olaf. Sometimes it can be better to take the precursors than the supplement itself. For example, many nutritionists recommend taking selenium and other minerals instead of actual glutathione.

http://www.amazing-glutathione.com/l-cysteine.html