Memory and a whole lot more: Neurological Disorders Cause and Effect

[Shadowself]

Memory is something that strikes us all. Particularly those who seem to remember things such as we do here of perhaps an unusual nature? Perhaps past life? Perhaps intermingled with other memory? Perhaps tampered with? Perhaps there's a reason we don't yet fathom as to those fleeting memories.

Forgetting. Is forgetting natures way of telling you something is wrong?



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On the heels of this very excellent thread for Caregivers and possible candidates of a disease which this year will effect according to statistics (in the US) over half a million and in the UK even more (800k the last I saw projected) not to mention worldwide statistics I would like to provide some information that I feel is being misdirected/downplayed/hidden from the public view for a variety of reasons which I will go into after I bring it to your attention here.

Here is the thread:

http://projectavalon.net/forum4/showthread.php?78069-Caring-for-relatives-with-Alzheimer-s-the-modern-curse-of-the-elderly

Note:

My mother suffered and died from this disease. I took care of her in her last years at home. I remember her sitting in the living room watching Jeopardy. A game show of sometime very hard questions to come up with the answers. I sat there watching her watching it and as the questions were revealed she would answer them. She not only answered them...she did so correctly. I was amazed. She was answering those questions which most people could never answer. The one that threw me for a loop was about an obscure island in the pacific which I'd never heard of in my life! But she did. Then the commercial came on and I said to her..."that's was amazing mom! How do you know stuff like that?" She sort of wandered her gaze from the television and looked around the house and said to me " this is a nice house...who's house is this?".

She had at that time been living there with me at my home for three years slowly deteriorating in memory and physical health.

So how does that work? She can remember some obscure Island in the Pacific but can't remember living at my house for the last three years?


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But this thread is NOT...I REPEAT NOT simply about Alzheimer's Disease. It's surrounding a huge variety of disorders and it's ramifications are indeed important where your health and existence in general are concerned. Particularly memory.

Now I know we all put our trust in the medical industry right? We know they wouldn't lie to us if they knew how to avert or exploit a common factor we all share?

So I'm closing this post with this song. Let it's words sink in as I attempt to show you something I discovered which I think we have a right to know. That has apparently been diverted from our attention. It can open a plethora thing of which I feel would concern you as a human being and the general overall condition of our health.

Again this is not simply about Alzheimer's. It's been studied and diverted from public knowledge as to it's importance and I believe it's time has come.

Enjoy the song as I make several posts on the subject and use this post as a placeholder for the information I'm about to bring you. Please hold off on comments until I finish. I will be happy to show you how THEY have diverted it from our attention which leads to trust issues no?

My message to the Medical & Scientific community for holding this back:

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BRB ;)

[Shadowself]

First: Okay here goes...

What I'm about to post is readily available online and can be researched if you have an interest.

So I'm going to link some interesting articles regarding certain aspects of Genetics which might interest you since you are after all a genetic being eh?

Can our DNA change as we get older? You bet!

Check it:

http://genetics.thetech.org/original_news/news91

DNA methylation

http://en.wikipedia.org/wiki/DNA_methylation

http://upload.wikimedia.org/wikipedia/commons/thumb/8/80/DNA_methylation.jpg/450px-DNA_methylation.jpg

Illustration of a DNA molecule that is methylated at the two center cytosines.

DNA methylation plays an important role for epigenetic gene regulation in development and disease.

~

Here goes....GENETIC REPOSE

(it's going to get a bit technical now but read it anyway as key elements are derived):

In living organisms, replication is based on DNA (the genotype) and the information encoded in DNA is used to build proteins (the major structural material of the phenotype).

DNA can serve both as a device for self-replication (genotype) and (surprisingly) as
a building material for nanoscopic structures and tools (phenotype). By choosing the
appropriate sequence of codons, DNA can be programmed to self-assemble into a wide
variety of structures, such as cubes, octahedra, one-dimensional strands, two dimensional meshes, and three-dimensional arrays.


Really? It's been suggested in one of the links I will provide in the end.


REST RE1-silencing transcription factor [ Homo sapiens ]

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis

Genetic Repose....

REST contains 8 Cys2His2 zinc fingers and mediates gene repression by recruiting several chromatin-modifying enzymes

UniProtKB/Swiss-Prot: REST_HUMAN, Q13127:

Function: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene
transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct
corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.
Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

~

The many faces of REST oversee epigenetic programming of
neuronal genes

Note:

Neurogenesis (birth of neurons) is the process by which neurons are generated from neural stem and progenitor cells. Most active during pre-natal development, neurogenesis is responsible for populating the growing brain with neurons.

Repeat...Sing it again:

REST RE1-silencing transcription factor [ Homo sapiens ]

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element.

The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis.

REST is found to be down-regulated in elderly people with Alzheimer's disease.

Interesting to note that REST strongly correlate with increased longevity. REST levels are highest in the brains of people who lived up to be 90 - 100s and remained cognitively intact.


The silencer (repressor) Gene;

http://en.wikipedia.org/wiki/Silencer_%28DNA%29

Mutated Silencers:

Among the many silencer elements and proteins, REST/NSRF is an important silencer factor that has a variety of impacts, not only in neural aspects of development. In fact, in many cases, REST/NSRF acts in conjunction with RE-1/NRSE to repress and influence non-neuronal cells.

REST/NSRF effects neural aspects of development!

It's beyond me to tell you exactly what that means....I'm guessing you can gather the ramifications?

Starting off...(there's more to come)

Science and such links provided in the content provided here:

http://en.wikipedia.org/wiki/Neurogenesis

http://www.genecards.org/cgi-bin/carddisp.pl?gene=REST

http://en.wikipedia.org/wiki/RE1-sil...ription_factor

Side note with interesting developments regarding the same subject:

http://arxiv.org/ftp/cs/papers/0502/0502087.pdf

http://en.wikipedia.org/wiki/Memory

VERY DOWN PLAYED yet recently made public....(next post)

http://www.ncbi.nlm.nih.gov/pubmed/24670762

http://www.ncbi.nlm.nih.gov/pubmed/25092546

http://www.omim.org/entry/600571

Interesting to notice that REST powerfully correlate with augmented longevity. REST levels square measure highest in the brains of individuals United Nations agency lived up to be ninety - 100s and remained cognitively intact. Levels stayed high specifically in the brain regions susceptible to Alzheimer's, suggesting that they could be shielded from dementedness. It's assumed that REST represses genes that promote necrobiosis and Alzheimer's unwellness pathology, and induces the expression of stress response genes. Moreover, REST powerfully protects neurons from aerophilous stress and amyloid β-protein toxicity.




From here: http://about.cusabio.com/c-18121.html

Ask yourself why this is not headline news where Alzheimer's Disease is concerned?



Next two posts a possible answer to that question.

[Shadowself]

I think people have a right to know and it's been drastically downplayed as a factor. Particularly in Alzheimer's Disease.

They are not telling the whole truth here.

The fact that Wikipedia has it listed in connection to Alzheimer's Here: http://en.wikipedia.org/wiki/RE1-silencing_transcription_factor

But not here is a puzzle no?

http://en.wikipedia.org/wiki/Alzheimer%27s_disease



They don't mention it here:

http://www.alz.org/alzheimers_diseas...hT2xoCJyvw_wcB

Here: http://stemcells.nih.gov/research/fu...s/Funding.aspx

Or here: http://www.eurostemcell.org/factshee...tem-cells-help

Go ahead and enter "alzheimer's desease NRST/REST" in the search engine here:

http://search.usa.gov/search?utf8=%E...se%20NRST/REST

NOTHING!

But believe me they've known for some time it's linked to Alzheimer's Disease and MORE!

Direct evidence of Stem Cell research on it: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855043/

There have even been applied for patents!

http://www.google.com/patents/EP1792911A1?cl=en

http://patents.justia.com/patent/20130203738

If you or someone you know has this disease or is genetically a probable match to get it I would think make this rather important.

It was briefly mentioned then swept under the table last March:

http://www.nytimes.com/2014/03/20/he...udy-finds.html

In fact the doctor/professor in this article plays it down as though this is some kind of new surprise. But it's been studied for quite some time!

But wait....this is going to interesting.....

[Shadowself]

Now...I'm going to make a HUGE presumption here:

Let me just say this; Before I decided to share this information I was given a warning of a very serious nature and threat. That's about all I will say about the threat here.

I've had a few days to think about that warning I had. For the life of me I'm not certain what exactly I was going to present in a very detailed post that would evoke such a response.

I can however make presumptions. This presumption is going to come on the heals of a very excellent post done by Jake the moderator in a thread here:

http://projectavalon.net/forum4/showthread.php?77187-Why--are-aliens-so-secretive-&p=919129&viewfull=1#post919129


What secret? Who doesn't know about aliens???

If any group of aliens doesn't want you to be aware of them,, then you would not BE aware of them.

Right now, we are like monkeys in a glass cage.. We can look out and observe our captors, but we really have zero concept of the levels of manipulation that unfold... Nor do we realize the levels of experimenting with Earth humans that occur..

I concur with Omni.. If the good guys can play with the humans, so can the bad guys.

This planet and its many multiple ages of man have seen this story unfold before..

They are all in their seats, front rows packed,, popcorn in hand,,, etc...

Our time here is fleeting... Very short lives... This is not so for many groups... The children (Earth Humans) don't have the lifespan to be indulged too much. There's an amazing truth at the end....

And that is the potentials that we carry... Every ET group knows and understands,, and they are all here for the show... The Earth Human race is like a fragile egg being tossed around.. Inside this egg with us is the histories and genetic memories of each onlooking group... If we could only keep it together, and hatch from our egg...

The amazing reality of ETs will PALE in the wake of the amazing reality of our true selves...

I think that they should all SCRAM... We have an amnesia to break out of and I do not see where they are helping. Though I do not see everything...

Never forget that the alien assigned to help you through all of this is in your mirror.. Smile at it,, it doesnt have long to convince you...

If ET really wanted to be clever,, they would take everyones TV... You'd have the worlds attention then!!! Lol

Jake...

So what's the big secret that I would be warned not to tell? If the science is out there (even though downplayed) on the genetic engineering level what difference does it make?

Well of course it makes a difference if they KNOW and have not worked to alleviate certain conditions that arise to avert notice when most likely the same genetic disposition is USED for other purposes? This is a "presumption". But a pretty educated guess non the less.

One BIG presumption:

Lets presume you belong to this very advanced intelligent group of scientists. You have this very large science lab. You want to create a controlled experiment in the lab. Let's presume it's a genetic engineering experiment.

You take this group of lab rats and control the birth of neurons...control the longevity of the neurons and cells. You want to control the brain and memory. YOU CAN TARGET SPECIFIC genes and create a plethora of "conditions".

What if that group of lab rats got smart enough to discover that as well as repressing neuronal genes that "silencing factor" could ACTIVATE the genes?

What than? Longer life....better and COMPLETE memory?

What if those lab rats found out and I quote:


After the participation in cells at early stages of neurogenesis, the NRSF/REST complex in the “differentiated state” appears to be explained. The cells that alter binding partners from repressors to activators...


So let me get this straight...they have learned through stem cell research how to turn a repressor into an activator?

A repressor that controls longevity....that controls the birth of neurons.....that controls memory can be "switched" into an activator?

My my.... we've come a long way as the lab rats we are.

Do you remember?.....Oops....there it goes. Gone again!

Perhaps it was just a dream.


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That's about all...except to add this protein is involved in FAR MORE than Alzheimer's....and it is highly involved with DNA methylation.

[Adi]

Very interesting stuff, you have done alot of research here.

Adi

[Billy]

Thank you Shadowself. After my first read i wanted to post this. Me thinks many more reads to come.

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Lets presume you belong to this very advanced intelligent group of scientists. You have this very large science lab. You want to create a controlled experiment in the lab. Let's presume it's a genetic engineering experiment.

EDIT: to add a snippet from one of my threads.


Who are the 24 Elders Part 4


Now this last section will bring forward what some scientist have brought to the table this last few years. Scientist who in some cases have managed to think outside the restriction box.

Our Junk DNA is the topic.

In concluding, My own personal belief is that humanity has the essence of many universal civilizations within them. Those civilizations are from many levels. from the highest to the lowest. Humanity has within them the Key towards universal peace. This peace begins with self then expands outwards to our neighbours and countries, Then the universal peace begins. because we have brought them together within us.
Peace be with you all.
Billyji

[Shadowself]

Thank guys! I was a bit nervous as this is after all my first thread here. I know it's a bit technical. I can't help that. It's a technical subject. I tried the best I could to make it understandable.

What I've provided here is only a small fraction of the research I've done on this. Let's just say I have this personal interest in Protein Analysis and Evolutionary Relationships that it would peak my interest. Besides the fact that my mother came down with a related disease.

It's not just about Alzheimer's however. Not by a long shot.

I also realize my "presumption" post was a bit out there....but so was my warning and threat.

[johnh]

Wow. Thank you for this post and all the hard work involved, including some courage.

At 66 years I have a hint of this, but my youngest brother at 61 is in a nursing home with severe dementia and a permanent feeding tube. He was built like a greek god when he was a young man and has had every possible test to see what brought this on and nothing seems to be known, at least that's what we are being told. Very saddening to see this.

A naturopath told me a couple of years ago after dowsing me that I was a prime candidate for alz/dem. So I have been taking selenium, magnesium, and chlorella daily to prevent the onset of this slippery slope with some success (still have to work). Also, hearing problems run in the family - seems to be genetic. Also, off world factors, the US Navy, and the Jesuits play into our family history. There will likely be some blow back for even having posted this. I know I am tracked but do have some friends that can be sometimes helpful. Definitely a tug of war going on.

[Shadowself]

Thank you for sharing that Johnh. I'm so sorry to hear about your younger brother. This is never easy to live with I know.

I think in the next few days/weeks I'm going to put this whole subject into laymen terms (best I can) because it is really a key to many things I think we should understand. I know when I figured it out it turned on this huge light bulb in my head which has yet to go out.