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Okay. So my vote for best female villain in a TV show (btw, Annie Wilkes in Misery mentioned above would indeed also be the best in a movie for me) goes to Aunt Lydia from the Handmaid's Tale.
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Since I watched it a few days ago on Netflix I think this is a really good candidate for this thread:

US Army Colonel Richard Strickland played by Michael Shannon in 'The Shape Of Water'.
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