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6th January 2021 18:20
Link to Post #1
Avalon Member
Indian scientists found "Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1"
On December 31st, 2020 a study was published by Indian scientists that found uncanny similarities between 2019-nCoV spike proteins and the ones found on the HIV-1 envelope, which does not seem fortuitous.
Of note, the article was withdrawn 6 days later.
The scientists conclude the article with:
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Conclusion
Our analysis of the spike glycoprotein of 2019-nCoV revealed several interesting findings:
First, we identified 4 unique inserts in the 2019-nCoV spike glycoprotein that are not present in any other coronavirus reported till date. To our surprise, all the 4 inserts in the 2019-nCoV mapped to short segments of amino acids in the HIV-1 gp120 and Gag among all annotated virus proteins in the NCBI database. This uncanny similarity of novel inserts in the 2019- nCoV spike protein to HIV-1 gp120 and Gag is unlikely to be fortuitous.
Further, 3D modeling suggests that atleast 3 of the unique inserts which are non-contiguous in the primary protein sequence of the 2019-nCoV spike glycoprotein converge to constitute the key components of the receptor binding site. Of note, all the 4 inserts have pI values of around 10 that may facilitate virus-host interactions.
Taken together, our findings suggest unconventional evolution of 2019-nCoV that warrants further investigation. Our work highlights novel evolutionary aspects of the 2019-nCoV and has
implications on the pathogenesis and diagnosis of this virus.
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Please read the full article here... https://www.biorxiv.org/content/10.1...871v1.full.pdf
Last edited by holcaul; 6th January 2021 at 18:30.
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6th January 2021 18:42
Link to Post #2