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    UK Avalon Member Sérénité's Avatar
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    Default Safety issues over CRISPR technology used in Cov19 vaccines for pregnant women?

    I’ve read a few articles recently on the dubious safety of CRISPR, the gene splicing technology that is being used in the MRNA vaccines for Covid-19.

    “Using the CRISPR system adapted from bacteria, RNA can guide scissors-like enzymes to specific sequences of DNA in order to eliminate or edit a gene. This technique has already been used in trials to cure sickle cell anemia. Now it is also being used in the war against COVID”
    https://time.com/5927342/mrna-covid-vaccine/



    CRISPR short for clustered regularly interspaced short palindromic repeats has been in research and use for a long time prior to being used for the Covid-19 vaccines.

    But how safe is this process for use during pregnancy?

    This article suggests it isn’t;

    https://www.statnews.com/2020/10/29/...ng-on-embryos/

    Lab tests show risks of using CRISPR gene editing on embryos
    “A lab experiment aimed at fixing defective DNA in human embryos shows what can go wrong with this type of gene editing and why leading scientists say it’s too unsafe to try. In more than half of the cases, the editing caused unintended changes, such as loss of an entire chromosome or big chunks of it.”

    Columbia University researchers describe their work Thursday in the journal Cell. They used CRISPR-Cas9, the same chemical tool that a Chinese scientist used on embryos in 2018 to help make the world’s first gene-edited babies, which landed him in prison and drew international scorn.

    The tool lets scientists cut DNA in a precise spot and has profound potential for good — it’s already used to raise better crops and livestock, holds promise for treating diseases, and earned its discoverers a Nobel Prize earlier this month.

    But using it on embryos, sperm, or eggs makes changes that can pass to future generations. Several international panels of scientists and ethicists have said it’s too soon to know whether that can be done safely, and the new Columbia work shows the possible harm.


    If our results had been known two years ago, I doubt that anyone would have gone ahead and tried it on embryos intended for pregnancy, said biologist Dieter Egli, who led the study.

    Okay maybe I have this wrong...but if they feel that CRISPR could make negative changes to an embryo that may not only affect that embryo but make changes that could potentially affect the future generations coming from that embryo...is this not then occurring when the MRNA CRISPR technology is now being used on pregnant women???

    This article also shares its concerns;
    https://www.the-scientist.com/news-o...-embryos-67668

    CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos
    Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.



    The ability of CRISPR gene-editing technology to safely modify human embryos has been cast into doubt after several recent papers described massive disruptions to DNA in embryos subjected to editing.

    Each of the three papers, published this month without peer review on the preprint server bioRxiv, intended to edit only a single gene. But results showed large-scale, unintended DNA deletions and rearrangements in the areas surrounding the targeted sequence. While past research has shown that gene editing can lead to mutations far away from the targeted region, these studies instead draw attention to more localized damage involving larger sequences of DNA that could be overlooked by traditional safety screenings, Nature reports.

    These studies were intended only for research purposes, meaning the embryos were destroyed after the experiment ended. But in response to their findings, many researchers are voicing their objections to further editing. The field itself is still grappling with the fallout from the birth of twin girls as a result of highly controversial CRISPR experiments carried out by He Jiankui at the Southern University of Science and Technology in China in 2018.

    “There’s no sugarcoating this,” Fyodor Urnov, a geneticist and CRISPR researcher at the University of California, Berkeley, who was not involved with the research, tells OneZero. “This is a restraining order for all genome editors to stay the living daylights away from embryo editing.”

    In the first study, published June 5, researchers at the Francis Crick Institute used CRISPR to remove the POU5F1 gene—an important contributor to embryonic development and stem cell pluripotency—in 18 embryos. When they analyzed the effect of the deletion on the genome, they unexpectedly found that eight of these embryos contained additional abnormalities, four of which involved substantial DNA rearrangements and deletions of several thousand base pairs.

    A second group from Columbia University attempted to modify embryos with a blindness-causing mutation in the EYS gene, the most common gene implicated in the onset of a degenerative eye condition called retinitis pigmentosa. But in addition to the expected changes, they reported on June 18 that almost half of the 23 embryos also lost large chunks of the chromosome on which EYS is located. In the most extreme cases, the chromosome disappeared entirely.

    Lastly, a study published June 20 by researchers at Oregon Health & Science University similarly focused on correcting a mutation in the MYBPC3 gene that is known to cause a heart condition. While they were successful in repairing the damage in close to half of the 86 embryos—a complement to their pioneering work in 2017—the authors also reported large disruptions in the chromosome containing the gene.

    Taken together, these three studies highlight the contrast between off-target effects, which happen when the CRISPR tools edit someplace unintended, and on-target edits, in which the changes are properly localized but have some unintended consequence. In each case, the on-target effects were unexpected.

    What that means is that you’re not just changing the gene you want to change, but you’re affecting so much of the DNA around the gene you’re trying to edit that you could be inadvertently affecting other genes and causing problems,” Kiran Musunuru, a cardiologist at the University of Pennsylvania who was not involved in any of the studies, tells OneZero.

    These problems also show just how little is known about the ways in which the body naturally repairs molecular cuts to the genome made by CRISPR technology, Nature reports. Rather than neatly heal the newly cleaved ends of DNA subjected to editing, the mechanism can sometimes be faulty, leading to degraded or broken DNA.

    Speaking to Nature, Urnov says these on-target effects warrant the attention of researchers moving forward. “This is something that all of us in the scientific community will, starting immediately, take more seriously than we already have. This is not a one-time fluke.”
    Last edited by Sérénité; 8th November 2021 at 08:32.

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    Default Re: Safety issues over CRISPR technology used in Cov19 vaccines for pregnant women?

    Like all technology it can be used for both good and bad.


    The history of vaccines and the satanic monsters behind them where Nazi style laws were introduced by most governments around the world - should raise a great deal of concern, especially when nearly 99% of people will not benefit from the vaccine, infact quite the contrary.

    Many drugs produced by big pharma have killed millions and this vaccine is no different where I suspect the blood clot side effect will be a slow killer.

    When we see Nazi firms like I.G Farben, Bayer and Monsanto together with Prince NAZI Philip, Bill Gates, Jeffrey Epstein and Dr Fauci involved with funding crispr gene editing technology what could possibly go wrong - EVERYTHING !!!

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