Melatonin inhibits NLRP3 inflammasomes
Melatonin is well known for its chronobiotic effects, which regulate biological functions related to circadian rhythms. Numerous studies have revealed that melatonin exerts effects beyond the control of circadian oscillators. The NLRP3 inflammasome is now recognized as a target of melatonin!
The fact that the effects of the pro-inflammatory cytokine storm are induced by the activation of NLRP3 inflammasome, the ability of THEHP3 INHIBIT inflammasoma melatonin elevates this powerful molecule into a truly unique position in the fight against COVID-19. This also means that if a patient, regardless of age, has adequate melatonin, coVID-19 contagion will be greatly reduced and the chances of developing ARDS/ALI will decrease significantly.
Melatonin is why children under the age of 9 rarely experience severe symptoms. In fact, children may have mild or even absent symptoms, even if they have been infected with SARS-CoV-2 [73]. How significant is the difference in melatonin production between children, adults and the elderly?
For most people, the peak melatonin production is between 2 a.m. and 3 a.m. The maximum melatonin levels measured in healthy adults aged 65 to 70 years appeared to be about 49.3 picograms/ml (pg/ml). Adults over the age of 75 have only maximum production levels of 27.8 pg/ml [74].
Young children, on the other hand, have extremely high levels of melatonin, compared to adults. The highest levels recorded for children showed a decline as they got older. Children aged 1 to 5 years had a melatonin peak at 325 pg/ml, while those aged 5 to 11 years had already dropped to 133 pg/ml [76].
Compared to healthy seniors, a child can easily have TEN TIMES the amount of peak melatonin levels. But even in this case, the current physiological concentration is extremely low. How much exactly does a picogram cost?
To give you a perspective, most melatonin supplements are about 3-5 mg per capsule or tablet. One milligram equals 1,000,000,000 picograms. That is why the physiological dosage generally recommended for melatonin supplementation is about 0.3 milligrams [75].
The fact that young children have such high melatonin levels explains why they show very mild symptoms after COVID-19 infections.
Melatonin is a powerful inhibitor of NLRP3 inflammasomes.
Generally referred to as the "dark hormone," melatonin's ability to regulate both pro and anti-inflammatory cytokines under different pathophysiological conditions has been extensively studied in recent years.
Control of cytokine storms is one of the biggest challenges in the treatment of sepsis. The NLRP3 inflammasome has an interesting nickname of "Pandora's Vase for Sepsis. Yet nature offers all the solutions to difficult health challenges.
NLRP3 inflammasomes are a direct target of melatonin. Animal models of sepsis showed melatonin's ability to maintain mitochondrial homeostasis, reduce reactive oxygen species and reduce the production of pro-inflammation cytokines. Melatonin has been shown to inhibit NLRP3 inflammasomes in mice with septic myocardial conditions, turning severe myocardial inflammation into milder symptoms, preventing heart failure and significantly improving heart failure rates survival of septic mice [77, 78].
An excellent study by Volt et al (2016) showed that low chronic doses of melatonin in older mice could prevent an increase in inflammation, ROS and mitochondria alterations that reflect inflammation [79, 80]. Volt et al. it also showed that acute melatonin administration could counteract severe inflammatory responses [81].
It is therefore not surprising to find that melatonin is able to prevent ARDS/ALI by suppressing NLRP3 inflammasomes.
In models of acute lung damage from rodent (ALI), it was found that melatonin greatly reduces lung damage, and also the infiltration of macrophages and neutrophils into the lungs.
Melatonin protected mice from acute lung injury by inhibiting the activation of NLRP3 inflammasome by suppressing extracellular release of histones and blocking the activation of the histone-induced INflammasoma NLRP3 .
In rodent models of acute respiratory distress syndrome (ARDS), the combined treatment of melatonin and mitochondria significantly attenuated the progression of ARDDS [85].
Re: The Wuhan Coronavirus [Covid-19, the Honey Badger virus]
But I'm 100% totally fine here. 
It's critical of Trump, of course, but rightly so. He's not the only national leader who's been very slow, and/or in public denial of reality.)
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