Antibiotic resistance clue found

Northern Boy · 09-13-2009, 05:15 PM

US scientists have uncovered a defence mechanism in bacteria that allows them to fend off the threat of antibiotics.
It is hoped the findings could help researchers boost the effectiveness of existing treatments.
The study published in Science found that nitric oxide produced by the bacteria eliminates some key effects of a wide range of antibiotics.
One UK expert said inhibiting nitric oxide synthesis could be an important advance for tackling tricky infections.
Antibiotic resistance, for example with MRSA, is a growing problem and experts have long warned of the need to develop new treatments.

Here, we have a short cut, where we don't have to invent new antibiotics
Dr Evgeny Nudler, study leader
The latest research, done by a team at New York University, showed that in bacteria the production of nitric oxide - a small molecule made up of one nitrogen and one oxygen atom - increased their resistance to antibiotics.
They found the enzymes responsible for producing nitric oxide were activated specifically in response to the presence of the antibiotics.
They also showed that nitric oxide alleviates damage caused by the drugs as well as helping to neutralise many of the toxic compounds within the antibiotic.
The researchers then showed that eliminating nitric oxide production in the bacteria allowed the antibiotics to work at lower, less toxic doses.
More effective
Study leader, Dr Evgeny Nudler, said developing new medicines to fight antibiotic resistance, such as that seen with MRSA is a "huge hurdle".
"Here, we have a short cut, where we don't have to invent new antibiotics.
"Instead we can enhance the activity of well-established ones, making them more effective at lower doses.
Dr Matthew Dryden, consultant in microbiology and communicable disease at Royal Hampshire County Hospital and general secretary of the British Society for Antimicrobial Chemotherapy, said if the enzyme which creates nitric oxide could be inhibited, it could suppress the ability of the bacteria to counteract antibiotics.
"This would be a useful therapeutic advance, especially as we are running out of new classes of antibiotics and there is less antibiotic development in general."

http://news.bbc.co.uk/2/hi/health/8248020.stm

mntruthseeker · 09-13-2009, 05:35 PM

My believe for a very long time is that this has always been a posibility

When God created the universe he didnt create medicine as it wasn't needed.
He gave us what we needed in the trees and plants he put upon the planet.
So full of vitamins, nutrients and minerals.

Lucifer's helpers create desease and the people need to stop taking their medication because it only makes them sicker.

Big Pharma and the CDC and the PTB have much to answer for

09-13-2009, 05:15 PM	#1
Northern Boy Avalon Senior Member Join Date: Oct 2008 Location: On this Rock Posts: 1,390	Antibiotic resistance clue found US scientists have uncovered a defence mechanism in bacteria that allows them to fend off the threat of antibiotics. It is hoped the findings could help researchers boost the effectiveness of existing treatments. The study published in Science found that nitric oxide produced by the bacteria eliminates some key effects of a wide range of antibiotics. One UK expert said inhibiting nitric oxide synthesis could be an important advance for tackling tricky infections. Antibiotic resistance, for example with MRSA, is a growing problem and experts have long warned of the need to develop new treatments. Here, we have a short cut, where we don't have to invent new antibiotics Dr Evgeny Nudler, study leader The latest research, done by a team at New York University, showed that in bacteria the production of nitric oxide - a small molecule made up of one nitrogen and one oxygen atom - increased their resistance to antibiotics. They found the enzymes responsible for producing nitric oxide were activated specifically in response to the presence of the antibiotics. They also showed that nitric oxide alleviates damage caused by the drugs as well as helping to neutralise many of the toxic compounds within the antibiotic. The researchers then showed that eliminating nitric oxide production in the bacteria allowed the antibiotics to work at lower, less toxic doses. More effective Study leader, Dr Evgeny Nudler, said developing new medicines to fight antibiotic resistance, such as that seen with MRSA is a "huge hurdle". "Here, we have a short cut, where we don't have to invent new antibiotics. "Instead we can enhance the activity of well-established ones, making them more effective at lower doses. Dr Matthew Dryden, consultant in microbiology and communicable disease at Royal Hampshire County Hospital and general secretary of the British Society for Antimicrobial Chemotherapy, said if the enzyme which creates nitric oxide could be inhibited, it could suppress the ability of the bacteria to counteract antibiotics. "This would be a useful therapeutic advance, especially as we are running out of new classes of antibiotics and there is less antibiotic development in general." http://news.bbc.co.uk/2/hi/health/8248020.stm

09-13-2009, 05:35 PM	#2
mntruthseeker Avalon Senior Member Join Date: Sep 2008 Location: Minnesota Posts: 2,482	Re: Antibiotic resistance clue found My believe for a very long time is that this has always been a posibility When God created the universe he didnt create medicine as it wasn't needed. He gave us what we needed in the trees and plants he put upon the planet. So full of vitamins, nutrients and minerals. Lucifer's helpers create desease and the people need to stop taking their medication because it only makes them sicker. Big Pharma and the CDC and the PTB have much to answer for