Dangers of Vaping

[onawah]

Vaping’s Hidden Dangers — More Harmful Than You Think
Analysis by Dr. Joseph Mercola
December 28, 2024
https://articles.mercola.com/sites/a...n-dangers.aspx

https://media.mercola.com/ImageServe...angers-pdf.pdf

"Story at-a-glance
Vaping damages blood vessel function, even in the absence of nicotine, by reducing blood flow velocity in the femoral artery and decreasing venous oxygen saturation, which suggests impaired lung oxygen intake
E-cigarettes contain harmful chemicals beyond nicotine, such as lead, nickel and formaldehyde, which cause oxidative stress and inflammation, triggering impaired vascular function and long-term vascular diseases
The misconception that vaping is a safer alternative to smoking is challenged by findings that both nicotine and non-nicotine vapes impair vascular function, with nicotine vapes causing more substantial reductions
EVALI, a severe respiratory condition linked to vaping, remains a significant health concern, with ongoing cases highlighting the need for improved regulatory measures and public health strategies
The presence of toxic chemicals in e-cigarette vapor causes acute lung injury and systemic effects on multiple organs, emphasizing the need for further research and regulatory oversight to understand and mitigate these health risks

E-cigarette or vaping product use-associated lung injury (EVALI) is a severe respiratory condition linked to the use of vaping products. It’s characterized by symptoms such as shortness of breath, cough, chest pain, and gastrointestinal issues like nausea and vomiting.

EVALI could escalate rapidly, leading to hospitalization or even death. This condition emerged prominently in 2019, raising significant concerns about the safety of vaping as an alternative to traditional cigarette smoking.

Source: https://youtube.com/watch?v=fj8ITais-EI

EVALI Is Responsible for Thousands of Hospitalizations in the US
A comprehensive workshop report published in the Annals of the American Thoracic Society in September 2022 revealed alarming statistics about EVALI’s health effects.1 Over the course of the EVALI outbreak, more than 2,800 individuals were hospitalized, and 68 deaths were recorded across the U.S.

The report emphasized that while vitamin E acetate was initially identified as a primary culprit, approximately 20% of patients had exclusively used nicotine-containing e-cigarettes, indicating that other harmful substances also contribute to lung injuries.

The persistence of EVALI cases, even after the initial outbreak subsided, underscores the ongoing risks associated with vaping.2 Additional reports from various researchers suggest that EVALI is not merely a relic of the past but an enduring threat to vape users.

EVALI also poses long-term consequences for both vapers and the healthcare system. Patients who recover from EVALI experience lasting respiratory issues, and the healthcare infrastructure faces the burden of treating these severe cases.

Moreover, the misconception that vaping is a safer alternative prevents smokers from effectively quitting smoking, leading to sustained nicotine addiction and its associated health risks. Addressing EVALI is crucial not only for preventing acute lung injuries but also for safeguarding overall public health.

The Focus on Vaping’s Health Implications
E-cigarettes contain a variety of harmful chemicals, including vitamin E acetate, which has been identified as a significant contributor to lung injuries. Additionally, the presence of toxic metals and other substances in vaping aerosols causes cytotoxicity and inflammation.

Simply put, the harmful substances in e-cigarettes irritate and inflame the lungs, leading to EVALI. When inhaled, these chemicals damage lung tissue, impair oxygen exchange and trigger an inflammatory response. This inflammation spills over into the bloodstream, affecting other organs and causing long-term health issues.

Diagnosing EVALI could be challenging due to its symptoms overlapping with other respiratory conditions. Clinical assessments often rely on patient history and imaging studies, but these methods do not fully capture the extent of the damage caused by vaping. The lack of specific biomarkers for EVALI further complicates diagnosis, leading to misdiagnoses or delayed treatment.

Conventional treatments for EVALI often involve supportive care, such as oxygen therapy and corticosteroids, but these have their own drawbacks, including side effects like increased blood sugar levels and weakened immune response. Understanding the limitations of these treatments is important for anyone who thinks vaping is a safer alternative to smoking.

New Study Reveals the Damaging Effects of Vaping on Vascular Function
A CNN Health article reported on a study that explored the immediate effects of vaping on vascular health and oxygen levels in the body.3 The research, which has not yet been published in a peer-reviewed journal but has been presented at the Radiological Society of North America’s annual meeting, aimed to determine how using e-cigarettes, with or without nicotine, affects blood vessel function and lung oxygen intake.

The study included 31 individuals between 21 and 49 years old who smoked or vaped, and compared their results with 10 nonsmokers.4 Participants underwent MRI scans before and after vaping or smoking tobacco cigarettes to evaluate changes in their vascular and respiratory systems.

The findings indicated that vaping significantly reduces blood flow velocity in the femoral artery, which is vital for supplying oxygenated blood to the lower body. Additionally, oxygen saturation levels among the vapers dropped, indicating that their lungs were likely taking in less oxygen.5

One of the notable findings in the study was that vaping with nicotine resulted in the most significant reduction in vascular function, even more than traditional smoking. This challenges the common perception that e-cigarettes are a safer alternative to cigarettes. Furthermore, vaping without nicotine also negatively impacted blood vessel function, though to a slightly lesser extent.6

In a CNN Health article, Dr. Marianne Nabbout, lead author of the study and a radiology resident at the University of Arkansas for Medical Sciences in Little Rock, said:

"People mistakenly believe that electronic cigarettes are safer alternatives to tobacco-based cigarettes, but this is actually not true. Even if there was no nicotine in the e-cigarette, there could be other components that may be harmful. That is possibly why we saw these significant effects, even following non-nicotinized electronic cigarette vaping."7

The study emphasized that good vascular function is crucial for maintaining efficient blood flow, delivering oxygen and nutrients, and removing waste from the body. When your blood vessels cannot expand and contract properly, it puts you at risk of serious health issues such as blood clots, high blood pressure and stroke.8

Another significant aspect of the research was the reduction in oxygen saturation following vaping. Lower oxygen levels in the blood mean that the body’s organs and tissues do not receive the necessary oxygen to function optimally. Over time, this contributes to the development of vascular diseases, posing long-term health risks for regular vapers.9

The mechanisms behind these effects involve the inhalation of various chemicals present in e-cigarette vapor. When users vape, they are not just inhaling water vapor; the vapor contains harmful substances like lead, nickel, formaldehyde, propylene glycol and glycerin. These chemicals cause oxidative stress and inflammation in the blood vessels, leading to impaired endothelial function — the ability of blood vessels to dilate and constrict as needed.10

Additionally, the study found that even nicotine-free e-cigarettes are harmful due to the presence of other toxic components. This underscores the misconception that e-cigarettes without nicotine are harmless. The combination of these chemicals disrupts the normal functioning of the vascular system, making e-cigarette users more susceptible to cardiovascular diseases.11

Experts involved in the study emphasized the need for more research to confirm these findings and to understand the long-term implications of vaping. However, the immediate negative effects on vascular function and oxygen saturation provide compelling evidence against the notion that vaping is a safe alternative to smoking.

Dr. Albert Rizzo, chief medical officer of the American Lung Association, commented on the study, stating that vaping exposes users to more than just harmless water vapor:

"We don’t know a whole lot about the effects of the ingredients of e-cigarettes with regard to effects on our lungs, effects on our blood vessels, and even though there [are] supposedly less toxins than a regular cigarette, we don’t know the long-term effects of these modalities are. Tests like these keep showing there are short-term effects," he said.12

The Link Between Vaping and Lung Inflammation
A recent review published in the Annual Review of Physiology journal explored the harmful effects of e-cigarettes on lung health, particularly focusing on inflammation and acute injuries related to vaping.13 The research aimed to understand how vaping contributes to lung diseases and the underlying mechanisms that cause these health issues.

The study examined various groups, including young adults and nonsmokers who have started using e-cigarettes, and found that e-cigarette use is linked to significant lung inflammation and injuries, and has led to a rise in cases of EVALI.14

One of the key findings was that the chemicals in e-cigarette vapor, such as nicotine, causes cytotoxicity, which means they are toxic to cells in the lungs. This cytotoxicity causes inflammation, where the lung tissues become swollen and irritated. The study highlighted that this inflammation is not just a short-term issue but could cause chronic lung diseases over time.15

The research also delved into the role of neutrophils, a type of white blood cell, in the inflammation process. Neutrophils are meant to protect the lungs by moving to areas of harm and fighting infections. However, the chemicals in e-cigarettes disrupt their normal function, causing them to overreact and contribute to excessive inflammation. This overreaction damages the delicate structures in the lungs, making them more vulnerable to diseases.16

Furthermore, the study found that repeated exposure to e-cigarette chemicals affects multiple organs in the body, not just the lungs. This is because the harmful substances in the vapor enter the bloodstream through the lungs, reaching other parts of the body and causing widespread inflammation and damage.17

The mechanisms behind these harmful effects involve the rapid delivery of toxic chemicals into the bloodstream through the lungs. When users inhale e-cigarette vapor, they are not only taking in nicotine but also a cocktail of other harmful substances like heavy metals and toxicants. These substances cause oxidative stress, leading to cell and tissue damage.18

"Suppression of antimicrobial functions of both macrophages and neutrophils by e-cigarette aerosols in vitro and ex vivo supports the concept that e-cigarette use damages host defenses and will lead to increased susceptibility to pulmonary infections," the researchers said.19

Additionally, the study pointed out that the variety of chemicals in e-cigarette aerosols makes it difficult to pinpoint a single cause of lung damage. Instead, it is the combination of multiple toxic substances that triggers various health issues.20 This complexity underscores the need for comprehensive regulations to control the ingredients used in e-cigarette liquids and to protect public health.

These Strategies Will Help You Quit Smoking and/or Vaping
Addressing the damaging effects of vaping requires a comprehensive approach focused on restoring your overall health and strengthening your body from within. By taking these proactive steps to enhance your well-being, you’ll create a solid foundation that makes quitting smoking more achievable and less stressful:

•Get healthy before trying to quit smoking or vaping — Prioritize improving your overall health to increase your chances of successfully quitting these unhealthy habits. This involves optimizing your diet and ensuring your body is in the best possible condition to handle the challenges of quitting. When your body is healthy, it will better cope with the withdrawal symptoms and stresses associated with giving up nicotine.

•Optimize your diet with a focus on cellular energy production — Tailor your diet to support cellular energy production, which is crucial for your body’s repair and functioning. Incorporate foods that enhance mitochondrial health, such as those rich in antioxidants and essential nutrients. A well-balanced diet will provide the necessary fuel for your cells, promoting better vascular health and reducing the immediate impacts caused by vaping.

•Exercise regularly — Engage in regular physical activity to boost your cardiovascular health and increase your energy levels. Exercise helps improve blood flow, strengthens blood vessels and enhances oxygen delivery throughout your body. As you become more physically fit, your body will be better equipped to recover from the vascular stress caused by vaping, making the process of quitting smoking smoother.

•Build energy and reduce stress to facilitate quitting — As you adopt a healthier lifestyle through diet and exercise, you’ll naturally experience increased energy and reduced stress levels. This improvement in your overall well-being will make the decision to quit smoking less daunting and more manageable. With higher energy levels and lower stress, you’ll find it easier to resist cravings and maintain your commitment to a smoke-free life.

•Find a healthy emotional outlet — Many use exercise, meditation or relaxation techniques for this, and these are all great. I also recommend incorporating Emotional Freedom Techniques (EFT). This helps clear out emotional blockages from your system (some of which you might not even realize are there), thus restoring your mind and body's balance and helping you break the addiction and avoid cravings."

- Sources and References
1, 2 Annals of the American Thoracic Society, Jan 2023;20(1):1-17
3, 4, 5, 6, 7, 8, 9, 10, 11, 12 CNN Health, November 28, 2024
13, 14, 15, 16, 17, 18, 19, 20 Annu Rev Physiol. 2021 Nov 1;84:611–629

[haroldsails]

Tobacco is like an old lover who keeps calling you, testing your willpower to abstain.
It is just plain amazing how tobacco owns you - people who never smoked might not understand this, but quitting smoking is one of the hardest things a person will ever do. The addiction to nicotine is so freaking heavy (worse than alcohol IMO).
I had a tobacco habit that lasted decades, and I am grateful to have quit before vaping came along. Had vape cigarettes been around when I was struggling to quit, I'm certain I'd have just made the switch to vaping.
Incidentally, I must have "quit" several thousands of times over decades, and failed. The addiction does more than damage your lungs.

[Listkov]

people say that vaping tobacco is healthier than smoking it.
i doubt they've studied whether vaping heavy metals and the stuff they use to taxidermy fish is healthier than smoking it

people who aren't old enough to legally buy vapes, when you buy anything from a street dealer, most of it wouldn't pass the cartel's quality control

[onawah]

Quitting tobacco is difficult, but I was able to do it at age 30 after about 15 years of being a smoker, by really cleaning up my diet and drinking a lot of freshly made fruit and vegie juice, taking supplements, etc.
The cleaner my body got, the grosser smoking felt until finally I couldn't stand it anymore and had a psychological "SNAP" moment which gave me the momentum to quit.
(I also was listening to some self-hypnosis tapes directed specifically at quitting cigarettes which I think helped too.)
The vapor from vaping is also toxic second hand.
I was working in an office for a while next to someone who was vaping at her desk and it was giving me some bad headaches.
It should not be allowed in public anymore than smoking should.

[Mike Gorman]

Yes alright all of these things carry risks, breathing today's atmosphere in cities contains all kinds of particles, heavy metals and so forth. Setting out on a walk around your neighbourhood carries risk - it seems people are hyper sensitive to taking any kind of risk these days, they don't seem to understand that their lives have a 'use-by' date, that our graves are all empty of any kind of attainment or wealth: smoke your cigarette/tobacco if it gives you pleasure, that extra 10 years sitting around an old folks home-staring into oblivion won't get you any further along, 100 year old bored, healthy folks empty of all aspiration, absent of any sense of adventure or pleasure: I dislike this media-driven emphasis on ultra health, purity and puritanical techno-life! I smoke Dutch strong tobacco, it is that brand which forms the 'dark' part of Drum's bright & dark - I like smoking my 5-10 ciggies per day and it gives me something in return, live out your healthy extra 10-15 years in the old folks home if you like, at 67 I don't particularly care, all of life carries risks.

[onawah]

It was never about not wanting to take risks for me, it was about not wanting to be addicted to anything so toxic, not having better control over myself, and about spending money on a habit that was not only very unhealthy but made me smell bad, be short of breath, filled my lungs with disgusting phlegm, made me more susceptible to colds and flu, and made me feel stupid for ever allowing myself to have succumbed to the need to feel "cool" when I started smoking at age 15.
And knowing what an amazing thing the human body is, the "temple" of the human spirit, I felt ashamed of myself for polluting mine.
Especially when I finally understood that what I was polluting my lungs with was not just tobacco, but a number of very toxic chemicals as well, and how I and millions of other people had been deceived into thinking it was a relatively harmless habit.
And I was amazed at how much better I felt once I quit and had detoxified enough to know and feel what a great thing I had finally done for my body, and for my self esteem.

Posted by Mike Gorman (here)
Yes alright all of these things carry risks, breathing today's atmosphere in cities contains all kinds of particles, heavy metals and so forth. Setting out on a walk around your neighbourhood carries risk - it seems people are hyper sensitive to taking any kind of risk these days, they don't seem to understand that their lives have a 'use-by' date, that our graves are all empty of any kind of attainment or wealth: smoke your cigarette/tobacco if it gives you pleasure, that extra 10 years sitting around an old folks home-staring into oblivion won't get you any further along, 100 year old bored, healthy folks empty of all aspiration, absent of any sense of adventure or pleasure: I dislike this media-driven emphasis on ultra health, purity and puritanical techno-life! I smoke Dutch strong tobacco, it is that brand which forms the 'dark' part of Drum's bright & dark - I like smoking my 5-10 ciggies per day and it gives me something in return, live out your healthy extra 10-15 years in the old folks home if you like, at 67 I don't particularly care, all of life carries risks.

[Kalamos]

I don't know. I've been vaping pretty heavily for ten years and I'm fine. I never heard of EVALI until now. Pretty scary article there though. I think I'll go ahead and try and quit it, again. Wish me luck.

EDIT:

I did a 'little bit' of searching and found that EVALI linked to regular nicotine vapes has been debunked.

"THE SERIOUS LUNG CONDITION known as EVALI is not caused by vaping nicotine as falsely claimed by vaping opponents, according to a new study published today in Drug and Alcohol Review.

EVALI (E-cigarette, or Vaping, product use-Associated Lung Injury) causes breathing difficulty, shortness of breath and chest pain. In the US outbreak, it led to 2,807 hospitalisations and 68 deaths by February 2020.

It soon became clear that EVALI was caused by vaping black market THC (cannabis) oils contaminated with vitamin E acetate (VEA)."

More at: https://colinmendelsohn.com.au/evali-2/

[onawah]

There are conflicting reports, so it looks like further investigation may be necessary, and wise to keep in mind how many times medical "authorities" have been bought off and lied for profit.
( As for me, I wasn't imagining those headaches I was getting from second hand vaping--but it may depend on the particular product being used. )
Then there are the reports from Dr. Bryan Ardis saying that it's not nicotine that is addictive, but the chemicals that were intentionally added to cigarettes to make them addictive, to profit the cigarette producers.
Here's a 2023 report from the Mayo Clinic that supports the premise that vaping is harmful:
Speaking of Health
A doctor's warning about the dangers of vaping
November 15, 2023
https://www.mayoclinichealthsystem.o...gers-of-vaping

"Vaping is the term often used to describe the use of an electronic nicotine delivery system, or ENDS, including electronic cigarettes, or e-cigarettes, vape pens or vaporizers. These battery-operated devices heat a liquid solution — usually, but not always, containing nicotine — to turn it into a vapor that can be inhaled. If the base nicotine mixture isn't palatable, flavors like mint, apple and cotton candy, can be added that make vaping attractive, especially to adolescents. E-cigarettes can resemble a pen or USB flash drive, and may be disposable after one use or have rechargeable systems.

Unfortunately, today's teens, and even tweens, know more about vaping than their parents. First publicized as a safer alternative to smoking tobacco, vaping caught on because it didn't contain the carcinogens or tars found in most smoking tobacco products. Also, vaping was supposed to eliminate the dangers of secondhand smoke to those nearby.

It all sounded pretty harmless in theory. However, those theories were wrong.

Here are the dangers associated with vaping:
No matter the delivery method, nicotine is addictive.
Studies have shown that it may be harder to quit a nicotine addiction than a heroin addiction. Most discussions about helping teens stop vaping fail to address that they already may be addicted. In many cases, teens at this phase may a need replacement option or medications, such as bupropion, to help curb the nicotine cravings that can be overwhelming.

If you've ever tried to quit smoking or had friends or family members try to quit, you know how difficult it can be. That's why, in certain situations, e-cigarettes still are considered an option to help someone who has smoked tobacco for years to become a nonsmoker.

The flavors and stabilizers in e-cigarettes can cause unknown inflammation to delicate lung tissue.
All one has to do is turn on the national news to hear about more and more teens who suffered severe — sometimes irreversible — damage to the lungs, and in extreme cases have died as a result of vaping. Adolescents often believe that bad things happen to everyone else, but the risks associated with vaping are real.

Many teens are taking vaping a step further, adding cannabis, CBD oils and other dangerous additives. When patients go to the emergency department in respiratory distress from vaping, it's challenging for healthcare professionals to treat them due to the difficulty in correctly identifying what they inhaled, especially when they are intubated or unconscious.

The length of time spent vaping can be much longer than smoking a standard cigarette.
Did you know that it takes two to five minutes to smoke most cigarettes? On the other hand, e-cigarettes can last up to 20 minutes, delivering more nicotine and damaging chemicals to the lungs. In addition, some vaping mixtures can contain 20 times the nicotine in a single cigarette.

Brain development can be affected.
Nicotine can affect concentration, learning, memory and brain development, according to information and data from a new report from the surgeon general. Also, nicotine use in young adults can still lead to other illicit substance use.

People under 21 can't buy tobacco products, including vape products, under federal law.

Talk about the dangers of vaping
Talk with your kids about the dangers of vaping, but also look for warning signs including:
Changes in emotions or new behaviors like secrecy
Dry cough or wheezing
Scents of fruity odors on skin, breath and clothes
Strange cylinders, chargers or batteries lying around
Trouble sleeping
Remember, it's essential to have conversations rather than suspicions and accusations. Encourage your teen to look into the warnings and media stories related to vaping or contact their healthcare team with questions.

Many healthcare professionals ask their patients about alcohol, drug use and smoking, yet forget to ask about vaping. Project for Teens is an example of a local outreach program that provides support and education on the dangers of vaping. Similar programs may be available in your area. Find resources to help teens quit through the American Lung Association and teen.smokefree.gov.

It's up to everyone to work together as a community to stop the young population from starting or continuing to use vaping products.

In this video, pulmonologist Adel Zurob, M.D., explains the risks of vaping, smoking and using chewing tobacco, and how the products harm your health:"

Source: https://youtube.com/watch?v=9pU3Ls2h2M8

[Kalamos]

Disposable E-Cigarettes More Toxic Than Traditional Cigarettes
High Levels of Lead, Other Hazardous Metals Found in E-Cigarettes Popular with Teens

https://www.ucdavis.edu/news/disposa...nal-cigarettes

I think it's time I quit this crap.

[onawah]

Good decision!

Posted by Kalamos (here)
Disposable E-Cigarettes More Toxic Than Traditional Cigarettes
High Levels of Lead, Other Hazardous Metals Found in E-Cigarettes Popular with Teens

https://www.ucdavis.edu/news/disposa...nal-cigarettes

I think it's time I quit this crap.

[rgray222]

Posted by Mike Gorman (here)
Yes alright all of these things carry risks, breathing today's atmosphere in cities contains all kinds of particles, heavy metals and so forth. Setting out on a walk around your neighbourhood carries risk - it seems people are hyper sensitive to taking any kind of risk these days, they don't seem to understand that their lives have a 'use-by' date, that our graves are all empty of any kind of attainment or wealth: smoke your cigarette/tobacco if it gives you pleasure, that extra 10 years sitting around an old folks home-staring into oblivion won't get you any further along, 100 year old bored, healthy folks empty of all aspiration, absent of any sense of adventure or pleasure: I dislike this media-driven emphasis on ultra health, purity and puritanical techno-life! I smoke Dutch strong tobacco, it is that brand which forms the 'dark' part of Drum's bright & dark - I like smoking my 5-10 ciggies per day and it gives me something in return, live out your healthy extra 10-15 years in the old folks home if you like, at 67 I don't particularly care, all of life carries risks.

Bravo, what a courageous reply. Even as a non-smoker, it seems to me that the corporate media would like us to do away with tobacco, red meat, caffeine, sugar, etc, which I believe in moderation are just fine. Also, common sense dictates that it should not bother or harm people nearby. Adding to your longevity by being warehoused in a nursing home is wrong on so many levels that it could be a topic for another thread.

[Mari]

Posted by rgray222 (here)

Posted by Mike Gorman (here)
Yes alright all of these things carry risks, breathing today's atmosphere in cities contains all kinds of particles, heavy metals and so forth. Setting out on a walk around your neighbourhood carries risk - it seems people are hyper sensitive to taking any kind of risk these days, they don't seem to understand that their lives have a 'use-by' date, that our graves are all empty of any kind of attainment or wealth: smoke your cigarette/tobacco if it gives you pleasure, that extra 10 years sitting around an old folks home-staring into oblivion won't get you any further along, 100 year old bored, healthy folks empty of all aspiration, absent of any sense of adventure or pleasure: I dislike this media-driven emphasis on ultra health, purity and puritanical techno-life! I smoke Dutch strong tobacco, it is that brand which forms the 'dark' part of Drum's bright & dark - I like smoking my 5-10 ciggies per day and it gives me something in return, live out your healthy extra 10-15 years in the old folks home if you like, at 67 I don't particularly care, all of life carries risks.

Bravo, what a courageous reply. Even as a non-smoker, it seems to me that the corporate media would like us to do away with tobacco, red meat, caffeine, sugar, etc, which I believe in moderation are just fine. Also, common sense dictates that it should not bother or harm people nearby. Adding to your longevity by being warehoused in a nursing home is wrong on so many levels that it could be a topic for another thread.

Two good posts and I agree with both. As an ex-smoker of 25 years now, I still miss the 'hit' that tobacco gave me and the social interaction of fellow smokers (what I believed to be really interesting and eccentric people - I was part of that club, haha) I too, am extremely irritated by the 'health police' which loves to denigrate the things that we love to do/consume. I've no intention of withering away in a nursing home - most definitely NOT in the UK...so called 'healthy' but completely doped up with meds - the chemical cosh that they give old un's to keep them quiet.

I agree about taking 'risks'. We are not here to live perfect 'clean' lives, but to experience life in all its diversity, so if that means I imbibe a little more wine that's good for me on occasion, then the relaxation, socialising, creativity and enjoyment I derive from it far outweighs, in my opinion, any 'risks' to my system.

[Sue (Ayt)]

And by coincidence, this medical article pops up today.

Vaping Better for Quitting Cigarettes Than Nicotine Replacement in Tough Population
— Randomized trial shows nearly triple the successful quit attempts in adults

MedPage Today
July 14, 2025 • 3 min read
https://www.medpagetoday.com/pulmonology/smoking/116500

[George]

I tried vaping and felt it was making me sick. Went back to regular tobacco. I think additive free tobacco is best. If a government that is trying to poison us in every way possible wants to protect us from the dangers of smoking - I take it with more than a grain of salt. So far the best advice was always to do the exact opposite..!

Of course there are risks. If you smoke, you die. If you don't - you also die... :-)

I wonder how many of us here are smokers?

[Vicus]

Just some comments...

As someone that has made sports all my life,today inclusive...because I needed, is just my character...and maybe this "lifestyle" allows that i can eat, smoke and drink everything I please...in moderate forms ...the only supplement took all my life is magnesium,after sports..

That is. ( everybody can just swim, is enough...2 or 3 times in the week...just 20 minutes, fun and relax, and give your body tone...)

I know that this forum is full with life veterans...but sometimes ...there are too many post about life styles like coming from an old folks resident...

Alcohol? well the Sumerians were the first to produce beer... but we are still here.

Tobacco? all studies from mummies from the Americas ( from where come the Tobacco plants ) until today isn't found 1 mummies die because cancer...

Wine? Greeks and Romans knew better...

Dont eat this or that...the Mediterranean diet,, considered the best in the world (other say the Japan/China ,) people living in those country's eat EVERYTHING that moves and everything that grow from dirt...

Conclusion: what make people ill ,fat,and bring in grave is just "industrial food and all the additives ..." and laziness...

[Bill Ryan]

Copying this interesting report (which I was not expecting!) posted by Ravenlocke on The Putin Thread:

~~~

Putin approved a full ban on vapes in Russia. The State Duma already supports the measure.

During a Friday meeting with Nizhny Novgorod Governor Gleb Nikitin, Vladimir Putin approved his proposal to ban vapes in the region as a starting point for a nationwide ban in Russia.

"I would be ready to serve as a pilot region here to ban this filth completely from retail, wholesale, and circulation," Nikitin said.

"Consider that I've already agreed immediately. It's a good proposal," Putin replied.

Today, State Duma Speaker Vyacheslav Volodin stated that "the absolute majority of deputies" support the ban.

https://x.com/sotanews/status/1959203787173761232

[Ravenlocke]

‼️🇷🇺🏴‍☠️Vapes and all electronic smoking devices must be banned throughout Russia

▪️The example of Governor Nikitin, who banned the sale of vapes in the Nizhny Novgorod region, should be followed by the heads of all regions.
➖"Vapes, ashkudishki, vaping systems, invented as an attempt to circumvent tobacco smoking restrictions, ultimately are an even greater evil than regular cigarettes," writes writer R. Antonovsky.
➖"In essence, it is harmful chemicals that you fill your lungs with, causing almost instant addiction and various diseases.
➖The absence of tobacco smoke and smell allows them to be smoked not only in specially designated places but practically everywhere: at home, in bed, which makes vape consumption almost continuous for some smokers.
➖The tasty fruity flavors make vapes and ashkudishki extremely popular among young girls, children, and teenagers.
▪️Vapes are a huge profit market for their manufacturers and a huge threat to the nation's health.
▪️In fact, it is still a legal drug. Vape manufacturers can be compared to drug cartels. They are sellers of death and disease.
▪️I wholeheartedly support the initiative approved by Putin and the Nizhny Novgorod governor and hope that soon vapes will be banned throughout Russia!"
- RVvoenkor

https://x.com/Zlatti_71/status/1959490260741624304

[onawah]

Unbelievable this was available without a prescription!

Posted by onawah (here)
7-OH/ FDA Warns of Dangerous Drug Sold in Stores Nationwide
Analysis by Dr. Joseph Mercola
September 19, 2025
https://articles.mercola.com/sites/a...&rid=391493809

https://media.mercola.com/ImageServe...arning-pdf.pdf

Source: https://youtube.com/watch?v=i0lnIrPA30A

"Story at-a-glance
The FDA has issued a nationwide warning about 7-hydroxymitragynine (7-OH), an opioid substance found in some products available in gas stations and convenience stores across the U.S.
7-OH binds strongly to opioid receptors and has been shown to be more potent than morphine, yet it is unregulated, lacks approved medical use, and is often sold without proper safety labeling
Many 7-OH products are disguised as energy shots or wellness aids, often with bright packaging that looks like candy or juice. This makes them easy to grab, especially for young consumers, and they’re frequently marketed with false claims for pain, anxiety, or mood support
Most 7-OH products sold in the U.S. are lab-altered or highly processed, delivering doses far beyond what’s found in natural kratom leaves and carrying a much greater risk of dependence and harm
If you’ve used 7-OH products, tapering gradually, supporting your body with movement, nutrition, and professional guidance helps reduce withdrawal symptoms and support a safe recovery process

You have probably seen them lined up by the cash register at a gas station or tucked onto the shelves of a corner store — small bottles of energy shots, brightly colored gummies, and novelty products that promise relaxation, focus, or a quick burst of energy. Their packaging is eye-catching and designed to feel as approachable as candy or soda, making them easy to grab without much second thought.

Behind those labels, however, many of these products contain a little-known ingredient called 7-hydroxymitragynine (7-OH), a byproduct of the plant kratom. The U.S. Food and Drug Administration (FDA) has issued an urgent nationwide warning against this substance, emphasizing that it carries serious health risks despite being sold openly as a “natural” product.1

The FDA’s announcement has drawn national attention and sparked urgent calls for action as 7-OH products continue to appear on store shelves without proper oversight. For you and anyone you care about, the warning serves as a reminder to look more closely at what’s being marketed as safe, because the stakes for your health could be greater than you realize.

Source: https://youtube.com/watch?v=gEcRQclVc28

FDA Cracks Down on 7-OH — A Potent Opioid Sold in Plain Sight
On July 29, 2025, the FDA took its first formal step toward restricting 7-OH, a potent opioid compound being sold in vape shops and convenience stores. The move follows growing concern that 7-OH is fueling patterns of misuse and addiction reminiscent of the early days of the opioid epidemic.2

•The FDA recommends scheduling 7-OH under federal law — The agency announced that 7-OH should be placed under the Controlled Substances Act, a decision that would classify it alongside other regulated opioids. U.S. Health and Human Services (HHS) Secretary Robert F. Kennedy Jr. framed the action as essential to protecting public health, stating:

“Today, we’re taking action on 7-OH as a critical step in the fight against opioid addiction. We will protect the health of our nation’s youth as we advance our mission to Make America Healthy Again.”3

•Potent opioid activity with no legal medical use — Regulators confirmed that 7-OH is a highly potent compound that acts on the same brain receptors targeted by opioids. Under the proposed scheduling, 7-OH would be designated as a Schedule I substance, the most restricted category reserved for drugs with high potential for abuse, no accepted medical use, and no established safety profile.

•FDA targets illegal sales and false claims — As a result, the FDA emphasized that it cannot be legally sold as a dietary supplement, food ingredient, or over-the-counter product. In June 2025, the FDA sent warning letters to seven companies marketing 7-OH in various formulations. These products made unauthorized claims for conditions such as anxiety, pain, opioid withdrawal, or mood disorders.

•Scientific review shows high risk of addiction and abuse — The scheduling recommendation was based on a full medical and scientific review, which concluded that 7-OH carries significant risks. FDA Commissioner Dr. Marty Makary warned that its spread could mirror the beginnings of the opioid crisis, when the dangers of prescription opioids were underestimated.

“Vape stores are popping up in every neighborhood in America, and many are selling addictive products like concentrated 7-OH. After the last wave of the opioid epidemic, we cannot get caught flat-footed again,” Makary stated. “7-OH is an opioid that can be more potent than morphine. We need regulation and public education to prevent another wave of the opioid epidemic.”4

•Public education campaign launched — The agency has released educational materials for public distribution, including a dedicated report for health providers and a consumer bulletin titled “Hiding in Plain Sight,” which highlights how these products are often disguised as kratom and sold without adequate warning.5

•Reports of severe health effects are mounting — Adverse event reports submitted to the FDA describe troubling outcomes linked to 7-OH use, including seizures, gastrointestinal distress, liver injury, depression, anxiety, insomnia, and withdrawal symptoms such as cold sweats, irritability, body aches, and restlessness. Given the severity of these, the agency urged consumers to avoid all products containing 7-OH.6

The FDA’s recommendation now moves to the Drug Enforcement Administration (DEA), which will decide whether to officially schedule 7-OH as a controlled substance. That process includes a public comment period before becoming law. Until then, the compound remains widely available in retail outlets, leaving the public exposed to unregulated products with opioid effects and real risks.

What Exactly Is 7-OH and How Is It Related to Kratom?
Kratom (Mitragyna speciosa) is a tropical evergreen tree native to Southeast Asia, where it’s long been used as a traditional remedy for fatigue, pain, and mood and anxiety disorders. The leaves contain dozens of alkaloids, but the one most abundant and pharmacologically significant is mitragynine, the compound from which 7-OH is formed in the liver.7

•Mitragynine is kratom’s primary alkaloid — Making up about 60% of the leaf’s alkaloid content, mitragynine acts as a partial agonist at the μ-opioid receptor. It produces stimulant and analgesic effects without fully activating the receptor in the way that drugs like morphine do.8

•7-OH is rare in the plant but extremely potent when isolated — In natural kratom leaves, 7-OH typically makes up less than 0.05% of total alkaloid mass. Only a small fraction of mitragynine is metabolized into 7-OH inside the body. Commercial products on store shelves often bypass this slow conversion process, delivering synthesized or extracted 7-OH directly at concentrations far higher than anything the plant itself provides.

•Pharmacology reveals potency and risk similar to opioid — Unlike mitragynine’s weaker receptor activity, 7-OH engages the μ-opioid receptor far more strongly. In animal models, it produces rapid pain relief at lower doses than morphine, with sedation and reinforcement that point to clear opioid-class effects.

Researchers describe both mitragynine and 7-OH as “atypical opioids” because they bias signaling toward pain-relief pathways, but this does not eliminate the risks of dependence, overdose, or other harm.

•Addiction potential is clear in experimental models — In laboratory studies, animals repeatedly dosed with 7-OH displayed opioid-like patterns of self-administration, withdrawal, and drug-seeking behavior. These findings align with user reports describing powerful sedation, rapid onset, and a strong compulsion to redose throughout the day — all markers of high abuse potential.

Understanding how 7-OH differs from the natural chemistry of kratom is key. In the plant, it exists only in trace amounts. When isolated and concentrated, however, it becomes a pharmacologically powerful drug with little research to guide safe use. That leap from trace metabolite to high-dose product is what transforms 7-OH into such a hazardous and unpredictable substance.

What About Fresh Kratom Leaves?
When headlines link 7-OH to kratom, it’s important to clarify that the plant and the compound are not the same. According to Christopher McCurdy, Ph.D., professor of medicinal chemistry and former National Institutes of Health (NIH) opioid chemistry fellow, fresh kratom and post-processed products differ significantly in chemical composition and potency.9

•Post-harvest processing shapes alkaloid content — According to McCurdy’s team, 7-OH appears to form during post-harvest changes, particularly drying and oxidation. The longer and harsher the processing, the more 7-OH is likely to develop. By contrast, lab tests on fresh leaf preparations from native Malaysian kratom trees showed no detectable 7-OH.

•Marketing doesn’t match chemistry — In the U.S., kratom is often sold under names like “red vein,” “green vein,” or “Maeng Da.” These labels suggest chemical consistency, but in reality, factors like soil quality, sunlight, harvest timing, and drying methods drive far more variation. McCurdy’s analyses found that even supposedly “strong” strains sometimes had low alkaloid levels, while cheaper or generically labeled samples tested stronger.

•Traditional teas and acidifiers extract selectively — Southeast Asian users typically brew kratom tea using fresh leaves and may add acidic ingredients like lemon juice to increase alkaloid solubility. This method extracts only a subset of compounds and avoids concentrating them to extreme levels. Alcohol- or solvent-based Western extracts pull out different sets of alkaloids, altering potency and effect, and introducing more 7-OH in the process.

•Safety depends on context and use — Compared to opioids or synthetic 7-OH products, fresh kratom appears to carry a more favorable safety profile, but that does not mean it is risk-free. It is a psychoactive substance, and its effects vary widely between individuals and products.

Certain types of kratom are still addictive, so make sure to do your research before trying it. One place to start is the American Kratom Association.10 Check out my interview with McCurdy in “Kratom as an Alternative for Opium Withdrawal” to learn more about this plant.

Until there are more standardized production and clearer research on long-term safety, kratom should be approached with care. For those considering this substance for pain relief, there are other safe and effective options to explore before turning to concentrated kratom products. Get a list of safer solutions for pain relief in “Opioid Deaths Continue to Rise Despite Drop in Prescriptions.”

6 Strategies to Help You Wean Off 7-OH Products
If you or a loved one has been using products that contain 7-OH, a thoughtful tapering plan makes the process safer and more manageable. Here’s how to approach it:11,12,13

1.Work with a health professional — Find someone familiar with withdrawal from natural substances, whether a physician, integrative practitioner, or other qualified provider who will take your experience seriously. A professional will help you come up with a withdrawal plan, monitor symptoms, and adjust the approach if challenges arise. This is especially important if you’ve been using 7-OH daily or at higher doses.

2.Reduce gradually, not all at once — Stopping cold turkey often leads to intense withdrawal. Instead, lower your intake step by step by cutting the dose or spacing out the time between doses. For instance, if you consume 7-OH product twice a day, reduce to once daily for a week, then shift to every other day.

3.Nourish your body properly — Give your system the resources it needs to adapt. Stay hydrated and focus on regular meals built around high-quality protein, healthy fats, and mineral-rich whole foods. Limit processed snacks, alcohol, and sugary drinks, which amplify fatigue, mood swings, and cravings.

4.Move daily — You don’t need intense exercise. Gentle, consistent activity, such as walking, stretching, or light yoga, helps regulate mood, reduce tension, and promote restorative sleep. Even 10 to 20 minutes a day reinforces progress and builds resilience.

5.Avoid other stimulants or sedatives — Now isn’t the time to lean on caffeine, alcohol, or other substances to take the edge off. They interfere with your body’s natural reset and make it harder to interpret withdrawal symptoms. Keep your inputs clean so your system resets without additional stressors.

6.Seek support and connection — Withdrawal has emotional as well as physical dimensions. Share your plan with a trusted friend, family member, therapist, or peer support group. Regular check-ins provide accountability, encouragement, and a reminder that you’re not doing this alone.

Coming off 7-OH may be challenging, but with these strategies, it’s possible to break free safely. Each small step is progress, and consistency is what makes the transition last.

Frequently Asked Questions (FAQs) About 7-Hydroxymitragynine
Q: What is 7-hydroxymitragynine, and why should I be concerned about it?

A: 7-hydroxymitragynine (7-OH) is a lab-synthesized or concentrated compound derived from the kratom plant. It acts like an opioid in your body and has been linked to serious health risks including seizures, withdrawal, liver injury, and addiction. The FDA has formally warned against its use and recommended that it be regulated as a controlled substance.

Q: I’ve seen 7-OH products sold in stores — how is that legal?

A: Right now, 7-OH is not yet classified as a controlled substance, which is why it’s still being sold in gas stations, vape shops, and online. But the FDA has called for it to be scheduled under federal law, and warned that it cannot legally be sold as a dietary supplement, food, or over-the-counter product.

Q: Is 7-OH the same as kratom, or are they different?

A: They’re different. While 7-OH is derived from kratom, it’s found in only trace amounts in the natural plant. Most 7-OH sold in stores is either synthesized or concentrated through heavy processing. Fresh kratom used traditionally has a different chemical profile and is far less potent than isolated 7-OH products.

Q: How do I tell if a product contains 7-OH before I buy it?

A: Check the label closely, but be aware — many 7-OH products are disguised under names like “kratom extract,” “enhanced kratom,” or “relaxation shots.” If the product promises intense effects like pain relief, euphoria, or opioid withdrawal support and doesn’t list full ingredients, it’s best to avoid it. The safest move is to steer clear of unregulated products entirely, especially those sold in gas stations or smoke shops.

Q: How do I safely stop taking products that contain 7-OH?

A: To taper off 7-OH safely, reduce your dose gradually instead of quitting suddenly. Work with a health professional who understands withdrawal. Support your body with hydration, nourishing food, regular physical activity, and emotional connection. Avoid stimulants or sedatives that could complicate the process. "


Sources and References
1 Fox News, July 29, 2025
2, 3, 4 U.S. FDA, July 29, 2025
5 FDA, Hiding in Plain Sight: 7-OH Products
6 U.S. FDA, “Products Containing 7-OH Can Cause Serious Harm”
7 ACS Cent Sci. 2019 May 29;5(6):992-1001
8 J Med Chem. 2021 Sep 1;64(18):13510-13523
9 YouTube, Mercola, Kratom as an Opium Substitute — Interview with Dr. Christopher McCurdy
10 American Kratom Association
11 Refine Recovery, What Is 7-OH? Guide to 7-Hydroxymitragynine
12 QuickMD, June 25, 2025
13 U.S. FDA, Preventing the Next Wave of the Opioid Epidemic: What You Need to Know About 7-OH [PDF]