Methylene Blue

[haroldsails]

We've been using MB as part of our morning routine for just shy of six months now. For the first 3 months we did ten drops twice daily, and then decided to cut back to once a day. Time to take a break from MB, but we will continue with most of the "frontline doctors" supplement protocol from the covid circus of 5 years ago, and our red light therapy. It will be interesting to see where this new revelation about MB leads us, how will the high profile proponents of MB respond, or will they even bother?

[Bill Ryan]

I've been following this thread, and all the pro-and-con points raised, with interest. (I've never tried MB, but I'm always alert to new ways of optimizing health and wellness.)

As a reminder (to myself also!), here's a copy of my post #16 from 6 months ago. The PDF embed doesn't seem to be visible to me here right now, but the link does work.

I do tend to trust Dr Mercola's views on things. He notes some potential side-effects, but does not feel it's in any way 'dangerous'. (If he's updated his opinion since then, please let us know!)

~~~!

Another feature from Dr. Mercola about Methylene Blue.

https://articles.mercola.com/sites/a...e-effects.aspx

Benefits and Side Effects of Methylene Blue — A Comprehensive Guide

Source: https://odysee.com/$/embed/@DoctorMercola:2/the-surprising-health-benefits-of-methylene-blue-interview-with-francisco-gonzalez-lima:3

Story at-a-glance

• Methylene blue enhances mitochondrial function and cellular energy production, improving cognitive function, liver health and overall cellular efficiency.

• Studies suggest methylene blue benefits Alzheimer's patients by slowing cognitive decline and brain atrophy. It also shows promise in treating depression.

• Methylene blue demonstrates liver-protective effects by activating SIRT1, enhancing fat metabolism and reducing inflammation. It also aids in estrogen metabolism, supporting hormonal balance.

• The compound exhibits potent anti-inflammatory properties by inhibiting multiple inflammasomes and reducing proinflammatory molecules. It helps manage various inflammatory conditions and improve survival in severe cases.

• While generally safe, methylene blue can cause side effects like blue discoloration of urine and interactions with certain medications. Proper dosage and pharmaceutical-grade products are crucial for safe use.

https://media.mercola.com/ImageServe...ffects-pdf.pdf

[meat suit]

I didnt realise MB was a MAOI..
You have to be really careful what you eat when taking a MAOI as it allows toxins to get through from some foods, especially aged things like certain cheeses, over ripe bananas etc.
Hence the Ayahuasca diet, if you are ever working with that.
the vine component is a MAOI which lets the DMT from the leaf component through..

Cacao has MAOI components too...

[TrumanCash]

I haven't experienced any benefit from Methylene Blue. No change whatsoever. I think I'll use what's left to dye some of my clothing. Seems pretty good for that. I take organic food-based supplements that create a positivel effect that I can actually feel and experience soon after taking them. I think it's over-hyped and tend to agree with Dr. Peter Breggin plus it is not natural.

[Gemma13]

I started taking Methylene Blue several months ago and instantly felt the effects of neuroplasticity, which was exciting. One of the symptoms I experience with my chronic illness is occasional interruptions to brain circuitry, much like a power outage or, if I’m lucky, a dimming of the lights—I can usually bluff my way through the dimming without looking like a stunned mullet.

But when the power goes out completely, I’m left in the dark waiting for it to kick back in. Happened the other day during a catch-up with friends. Mid-sentence, I froze. On the inside, I’m flapping around trying to reboot the circuit board. On the outside, mates are staring at me with an initial look of confusion that’s quickly replaced with relief that they’re not having whatever it is that I’m having.

We fumble our way to candles or a torch when the power goes out in our homes, but when I start scrambling for a torch inside my head, it makes me look spastic. My head swivels back and forth to everyone as my eyes plead for someone, anyone, to help me out. Geez, carry the baton on my sentence for a bit will ya, or toss out a trigger word to help reboot the crash. But I imagine at this point everyone is feeling as awkward and embarrassed as I am because they have no clue why my polished dialogue up and vanished only to be replaced with repeated utterances of “you know, you know, you know…”.

Gotta laugh, but it can be tricky in professional work situations, especially when I’m faced with a little public speaking which I now avoid like the plague. Fortunately, the short-circuiting doesn’t last more than a minute or so before the power magically reappears but then I’m faced with having to explain my way out of the fiasco.

Okay, so, Methylene Blue. I found that more is not better and it’s documented somewhere that this is the case, which makes finding the sweet spot dosage tricky. I found 5-6 drops per day way more effective than 15-16 drops. Then I swapped out daily for every 2-3 days.

Recently, I decided to stop it altogether, but I think that was a mistake. I experience episodes of the dimming effect when taking MB, but I can’t recall having had a significant glitch like the one I just described while I was on it. I’m reintroducing it now, but only on days that I venture out into the public square.

Oh, and I find it gives an additional hour or three energy kick when I take the dosage that works for me.

[Casey Claar]

I just can't get on board with this one. It just seems way off from right. I stay open to real research, discovery and data but can't see myself ever utilizing this.

[onawah]

I get that, Casey.
I am all about things that are NATURAL.
When it comes to a bluegreen supplement, I much prefer Spirulina, a complete food and the basis of the planetary food chain.
On the other hand, MB is supposed to be a remedy for something totally UNNATURAL, that being the self-replicating nanotechnology so recently introduced into the human bloodstream.
Perhaps Nature hasn't had time yet to create an effective natural remedy for that.
In any case, the microscopy work that Dr. Mihalcea and other researchers have been doing seems to be showing MB is effective.
Though I imagine some brands of MB may be adulterated, while others are more pure and work a lot better, though it will take more time to find out about that too, no doubt.
(These new toxins seem to be sneaking into everything, however!)
Cilantro is effective for eliminating heavy metal, and perhaps other natural remedies like that deserve more study as related to the nanotech.
I haven't been following dr. Mihalcea's work as much of late, but her team have probably been looking into that as well.

Posted by Casey Claar (here)
I just can't get on board with this one. It just seems way off from right. I stay open to real research, discovery and data but can't see myself ever utilizing this.

[RunningDeer]

Methylene Blue: Dosing & Uses | Strongest Energy Enhancer | Dr. Scott Sherr

• The Primal Podcast
• 524K subscribers
• September 6, 2025

Methylene Blue is a powerful mitochondrial enhancer and energy booster with wide-ranging benefits when used at the correct dose. Dr. Scott Sherr explores the science and therapeutic potential of Methylene Blue, including its effects on mitochondrial function, cellular energy production, neuroprotection, cognitive performance, and insulin resistance.

This discussion also covers the history of Methylene Blue, its mechanism of action at the cellular level, dosage strategies, and practical applications for health optimization and longevity.

In this conversation, Dr. Scott Sherr discusses the multifaceted benefits of methylene blue, particularly its role in enhancing mitochondrial health and its implications for mental health. He explains how mitochondrial dysfunction is linked to various mental health disorders and emphasizes the importance of addressing underlying issues such as GABA deficiency.

The discussion also covers the use of methylene blue in hypoxic conditions, its potential for weight loss support, and the necessary precautions when using it, especially in conjunction with other medications. Additionally, the conversation touches on the benefits of red light therapy for mitochondrial function and the significance of quality sourcing for supplements.

Takeaways:

• Methylene Blue enhances mitochondrial function and detoxification.
• 94% of adults experience some form of mitochondrial dysfunction.
• Insulin resistance is a major contributor to mitochondrial dysfunction.
• Methylene Blue can bypass dysfunctional mitochondrial complexes.
• The compound has historical significance as an anti-infective agent.
• Methylene Blue acts as a redox molecule, supporting energy production and detoxification.
• It can help recycle NAD, enhancing its effectiveness in the body.
• Low doses of Methylene Blue are recommended for optimal benefits.
• The compound has applications in cognitive enhancement and mental health.
• A holistic approach to health is essential alongside Methylene Blue use. Methylene blue can reduce exercise-induced fatigue and inflammation.
• Mitochondrial dysfunction is a key factor in mental health disorders.
• Higher doses of methylene blue can enhance neurotransmitter production.
• Methylene blue can help with low oxygen states during travel.
• It is important to monitor doses of methylene blue, especially with SSRIs.
• Methylene blue can support fat loss indirectly by improving mitochondrial efficiency.
• Red light therapy can enhance mitochondrial function and energy production.
• GABA deficiency can lead to anxiety and depression.
• Diet and lifestyle changes can improve GABA levels and overall mental health.
• Quality and source of methylene blue are crucial for safety and efficacy.

Source: https://youtube.com/watch?v=O-I_DO_GFYY

00:00 Exploring Methylene Blue
07:09 Mitochondrial Dysfunction
10:54 Holistic Health and Lifestyle Optimization
14:52 Historical Context of Methylene Blue
18:37 Methylene Blue and Mitochondrial Function
31:36 Methylene Blue in Insulin Resistance and Mental Health
42:58 Chemical-Free Skincare Solutions
45:14 Methylene Blue's Role in Hypoxia and Weight Loss
49:12 Methylene Blue and Fasting: A Synergistic Approach
53:18 Methylene Blue and SSRIs: Safety and Efficacy
57:32 Success Stories: Transformative Effects of Methylene Blue
1:05:46 Doses & Where To Get Methylene
1:16:32 Understanding GABA: The Brain's Inhibitory Neurotransmitter
1:22:45 Red Light Therapy: Enhancing Mitochondrial Health
1:26:13 Conclusion: Resources and Further Learning 1:51:37 The Role of Diet and Electrolytes

[ThePythonicCow]

Next time one needs to deal with Methylene Blue stains, at least on countertops and hands, try hot water with a spoonful of ascorbic acid (Vit C) dissolved in it. The hotter the quicker the blue turns clear; though, at least for most of us, our countertops can handle hotter water than our hands.

Hot ascorbic acid solution turns Methylene blue from one of the world's legendary blue stains into easily wiped off clear liquid that handles like plain (hot) water.

(If I wanted to relive the tie-died hippie days of a few years of my youth, I could try splotching hot ascorbic acid solution on some Costco Blue Jeans ...)

The heat just speeds the reaction, even cold ascorbic acid solution will turn Methylene blue clear, taking perhaps hours rather than seconds, depending on the temperature. Cooling the result back down does not reverse this reaction. It would take a reducing agent to "restore the blue." What that means practically, what I might have on my shelves that would work well to restore the blue color, I have not investigated. The internal chemistry of our bodies knows how to do this, oxidizing and reducing the Methylene blue back and forth to its transparent variant repeatedly. This is why Methylene blue is a useful "redox" (able to both reduce and oxidize) agent. Our body's chemistry finds such redox agents quite useful.

From what I've read, our bodies absorb the transparent, oxidized form more easily, so now I always mix my oral Methylene blue doses with hot ascorbic acid solution. Then just before drinking the now clear solution, I add an ice cube and some apple juice, to get a cooler, tastier, drink.

[grapevine]

Update on Brain Disease - Chase Hughes
Temporal Lobe Epilepsy with a possibility of Mesial Temporal Sclerosis

This video was posted on 20th September 2024 and gives a thorough account of Chase Hughes's condition, prognosis and treatment. As he's alive and well currently it would seem that using Methyline Blue together with red light therapy has been a huge success in this case, and I guess that if you have a disease like this you'd be ready to try anything (reasonable) that could help.

Source: https://youtube.com/watch?v=W4tXqcXeHHM

18:45

" Nine months ago, my brain was falling apart—I was having up to 9 seizures a day and didn’t even recognize my own family at times. Diagnosed with temporal lobe epilepsy, I was losing hope until I discovered something that changed everything: methylene blue. This blue dye from the 1800s, combined with melatonin and psychedelic therapy, helped me reverse my brain damage and regain my life.

In this video, I’ll share how these powerful molecules transformed my brain health, stopped my seizures, and might even help someone you know. "

Links:
RESEARCH: (only a tiny fraction of it)

Methylene Blue Research
https://www.academia.edu/101664825/Ne...
https://www.mdpi.com/2075-4418/10/4/2...
https://pubmed.ncbi.nlm.nih.gov/8971139
https://dx.doi.org/10.1115/1.1498850

Melatonin Research
https://pubmed.ncbi.nlm.nih.gov/18997997
https://dx.doi.org/10.2174/1570159X14...
https://www.mdpi.com/2076-3425/9/10/2...
https://dx.doi.org/10.1196/annals.133...
https://dx.doi.org/10.1111/jpi.12515
https://www.mdpi.com/2076-3425/11/9/1...

Join NCI University today to master human behavior & influence:
https://nci.university/10035

[Bill Ryan]

Bumping the thread with a tiny personal update. Intrigued by the wealth of interesting info on this thread, I'd ordered a small bottle of Methylene Blue last summer, which lived unopened on the shelf with my other supplements. This is what I have:

https://www.earthharmony.com/products/methylene-blue




Remembering that I had it, I opted to give it a try 7 days ago, carefully taking 3 mg (6 drops = 0.3 ml) every morning. This might be all in the mind! But I think I've felt an increase in energy. (And even if I just think that, it's no bad thing. ) If my provisional belief turns into an indisputable fact, I'll report it again here.

[Johnnycomelately]

Posted by Bill Ryan (here)
Bumping the thread with a tiny personal update. Intrigued by the wealth of interesting info on this thread, I'd ordered a small bottle of Methylene Blue last summer, which lived unopened on the shelf with my other supplements. This is what I have:

https://www.earthharmony.com/products/methylene-blue




Remembering that I had it, I opted to give it a try 7 days ago, carefully taking 3 mg (6 drops = 0.3 ml) every morning. This might be all in the mind! But I think I've felt an increase in energy. (And even if I just think that, it's no bad thing. ) If my provisional belief turns into an indisputable fact, I'll report it again here.

Love your Bill! I recently got a good dog neighbour, upstairs, named Lexi. Have met her several times, good times, and I believe that she is doing God’s work for my neighbours.

I’ve had M-blue applied to my leg-divot for several months now, in 3x weekly compression wraps. This is a ~3/16 inch thick ultra/AI blue solidish foam piece cut to size, mostly the type (of two) that needs wetting to activate it. The nurses say that it keeps things sterile. Am stoked to have found reference to and info about that thing here on PA.

Cheers!

[Bill Ryan]

Posted by Bill Ryan (here)
Bumping the thread with a tiny personal update. Intrigued by the wealth of interesting info on this thread, I'd ordered a small bottle of Methylene Blue last summer, which lived unopened on the shelf with my other supplements. This is what I have:

https://www.earthharmony.com/products/methylene-blue




Remembering that I had it, I opted to give it a try 7 days ago, carefully taking 3 mg (6 drops = 0.3 ml) every morning. This might be all in the mind! But I think I've felt an increase in energy. (And even if I just think that, it's no bad thing. ) If my provisional belief turns into an indisputable fact, I'll report it again here.

A little more. I did a controlled stress test this morning in the high mountains. As some readers may know from my thread titled Mara returns to the Mountains, I fairly often climb a local peak called Cerro Amarillo. It's an hour-long steep climb, and I can't remember NOT ever having to take a few seconds rest several times for a deep breath or two. (And not only that, there's a waterhole half way up where my dog Mara and myself always stop for 5 minutes for her to take a cool dip and a long drink.)

But today, I went straight up from the trailhead to the summit without stopping. (We never even stopped at the waterhole, as it was dry today.) I wasn't going faster: just maintaining my steady pace, but feeling that I never had to stop.

(So from an athletic physiology standpoint, it's a 'recovery' issue: I never had to stop to 'recover', as my real-time 'recovery' was keeping up with my energy expenditure all the time.)

This was my 10th day taking 3 mg/day of Methylene Blue, and I was totally impressed with my little experiment. The positive effect seems real. So I reported my experience to my friend Gilberto, the father and coach of his two super-athletic children Noam and Pema, both world-class mountain trail runners.

Gilberto was impressed too. He told me that many elite runners are taking Methylene Blue, their daily dose being 8—16 mg/day. So I've given him half of my long-lasting little bottle, and now Noam and Pema are going to start taking it every day as well.

[Szymon]

Hi Friends,

I don't take this stuff, but I recently came across an interesting post. Here it is, as an FYI. Draw your own conclusions.



More info about MAO

https://www.mayoclinic.org/diseases-...s/art-20043992

Cheers,
Szymon

[Bill Ryan]

Posted by Szymon (here)
Hi Friends,

I don't take this stuff, but I recently came across an interesting post. Here it is, as an FYI. Draw your own conclusions.



More info about MAO

https://www.mayoclinic.org/diseases-...s/art-20043992

Cheers,
Szymon

Many thanks, Szymon: I checked into that a little, and as best I can see it seems that (a) high doses of Methylene Blue would be needed to trigger that kind of problem, and (b) to be affected one might already have to have some kind of seratonin metabolism issue.

~~~

Today, I did another test. My dog Mara was off her food this morning and declined her breakfast (I feel sure not a serious thing), so I used the opportunity to try a strenuous solo hike which Mara might not have been able to do if she'd been with me.

Those of you who've read some of my hiking posts might recognize this pyramid-shaped mountain called Quitahuayco, the highest in the area. Here's a photo of my young friend Pema with Quitahuayco in the background. (This was taken half way up the trail to the summit.)



The last time I was up there was a full 2 years ago, really only because I thought with Mara now being a very senior dog the steep climb might be too much for her.

To my surprise, I made it to the summit in 90 minutes from the trailhead without stopping once. (Pema's Ecuador woman's record for the climb is 41 minutes, if I remember right — but she was running. )

I wouldn't have thought my own 90 minute time was possible, and — not a joke!! — I wondered if it might even be the Quitahuayco record for someone my age.

A couple of photos:





I talked with my friend Gilberto (Pema's father) some more about Methylene Blue, and he's been researching everything he can find about the benefits for elite athletes. Pema and her brother Noam are now taking it daily, already with clear benefits. Gilberto is pretty excited about it, and after starting to take it himself told me that he's experienced a marked difference in his mental clarity and focus. He, Noam and Pema are taking 10-15 mg/day.

I'm still only taking 3 mg/day, a pretty small dose. I've NOT felt any difference in mental focus, but clearly my ability to metabolize oxygen has greatly increased. I can only measure that objectively with these fun mountain stress tests (today being the second of these), but it seems reasonable to assume that this must surely be optimizing my whole well-being in more subtle ways.

[Johnnycomelately]

Posted by Bill Ryan (here)

Now that is a sensible hat, Bill, for high altitudes on a cloudy day. GOOD HUMAN!!

I wonder if those big and bald aliens’ heads ever think to wear a hat, or are they over that. 🥸

[Bruce G Charlton]

A word of caution:

Every psychoactive drug of which I know - i.e. traditional and SSRI type antidepressants, benzodiazepine type tranquillizers, antipsychotics/ neuroleptics, lithium, "mood stabilizers" of various kinds, psychostimulants etc; all produce dependence when taken for sustained periods in significant doses.

Dependence means that the body and brain get used to the drug, and make adjustments because of its continual presence - so that when the drug is withdrawn the body's own systems are (in a wide range of possible ways) thrown out from their natural balance.

The implications include that withdrawal should be gradual, so that the brain and body can adjust incrementally.

And that withdrawal effects should be expected, so that it is not necessarily correct to attribute symptom-problems after drug withdrawal to the return of the original problem, or its recurrence.

[Bill Ryan]

Posted by Bruce G Charlton (here)
A word of caution:

Every psychoactive drug of which I know - i.e. traditional and SSRI type antidepressants, benzodiazepine type tranquillizers, antipsychotics/ neuroleptics, lithium, "mood stabilizers" of various kinds, psychostimulants etc; all produce dependence when taken for sustained periods in significant doses.

Yes, absolutely.

I think the key phrase here may be significant doses. In Dr Mercola's excellent PDF (posted twice on the thread and linked here too) he recommends:

~~~

Serotonin syndrome risk — I would advise strong caution for anyone ever to take an SSRI drug. I don’t believe anyone benefits from them and would encourage you to read my last article on SSRIs. Taking methylene blue only worsens this risk as they increase serotonin levels even further.

This typically only occurs at high doses that are used to treat life threatening situations and is likely rarely, if ever, occur at lower doses that I recommend of 3 to 5 mg. This mostly occurs in those on SSRI drugs and taking doses of methylene blue over 100 mg.

~~~

That's why I decided to experiment with just 3 mg/day, with no plans to increase that. (In fact, I may even reduce it to 2 mg/day, or maybe every other day, as the metabolic benefit for me seems to be clearly demonstrated — again, rather to my surprise!)